The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse
Open accessAbstract
We hypothesized that rates of myofibrillar and patellar tendon collagen synthesis would fall over time during disuse, the changes being accompanied in muscle by decreases in focal adhesion kinase (FAK) phosphorylation and in gene expression for proteolytic enzymes. We studied nine men (22 ± 4 years, BMI 24 ± 3 kg m−2 (means ±s.d.) who underwent unilateral lower leg suspension for 23 days; five were studied between 0 and 10 days and four between 10 and 21 days. Muscle and tendon biopsies were taken in the postabsorptive state at days 0, 10 and 21 for measurement of protein synthesis, gene expression and protein phosphorylation. Muscle cross‐sectional area decreased by 5.2% at 14 days and 10.0% (both P < 0.001), at 23 days, i.e. 0.5% day−1, whereas tendon dimensions were constant. Rates of myofibrillar protein synthesis fell (P < 0.01) from 0.047% h−1 at day 0 to 0.022% h−1 at 10 days without further changes. Tendon collagen synthetic rates also fell (P < 0.01), from 0.052 to 0.023% h−1 at 10 days and then to 0.010% h−1 at 21 days. FAK phosphorylation decreased 30% (P < 0.01) at 10 days. No changes occurred in the amounts/phosphorylation of PKB–P70s6k–mTOR pathway components. Expression of mRNA for MuRF‐1 increased ∼3‐fold at 10 days without changes in MAFbx or tripeptidyl peptidase II mRNA, but all decreased between 10 and 21 days. Thus, both myofibrillar and tendon protein synthetic rates show progressive decreases during 21 days of disuse; in muscle, this is accompanied by decreased phosphorylation of FAK, with no marked increases in genes for proteolytic enzymes.
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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
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“from 3 to 5 days of disuse) in the fed as well as the fasted states, since it may be that one of the problems associated with immobilization is an ‘anabolic resistance’ to feeding as seen in the elderly (Cuthbertson et al. 2005).”
BackgroundInfluentialSelf-citationAtrophy of the soleus muscle by hindlimb unweighting
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Self-citationAtrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress
Paddon-Jones, D., Sheffield-Moore, M., Cree, M. G., Hewlings, S. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0651 · Cited by 254
Protein synthesis rates in atrophied gastrocnemius muscles after limb immobilization
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Cited by
Sarcopenia: characteristics, mechanisms and functional significance
Narici, M. V., & Maffulli, N. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldq008 · Cited by 827
Self-citationBreen, L., & Phillips, S. M. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-68 · Cited by 576
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Self-citationSkeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
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The impact of extended bed rest on the musculoskeletal system in the critical care environment
Parry, S. M., & Puthucheary, Z. A. (2015) · Extreme Physiology & Medicine · doi:10.1186/s13728-015-0036-7 · Cited by 383
Metadata
- Authors
- De Boer, M. D., Selby, A., Atherton, P., Smith, K., Seynnes, O. R., Maganaris, C. N., Maffulli, N., Movin, T., Narici, M. V., & Rennie, M. J.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2007-11-14
- Volume
- 585
- Issue
- 1
- Pages
- 241-251
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2133915158
- Cited by
- 343
- References
- 9
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- De Boer, M. D., Selby, A., Atherton, P., Smith, K., Seynnes, O. R., Maganaris, C. N., Maffulli, N., Movin, T., Narici, M. V., & Rennie, M. J. (2007). The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2007.142828
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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