BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
Open accessAbstract
Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic influences on corticospinal plasticity have been shown in human beings using transcranial magnetic stimulation, whereby healthy patients carrying the Val66Met polymorphism in the BDNF gene exhibited significantly smaller training-induced increases in motor evoked potential amplitude.
“Genetic influences on corticospinal plasticity have recently been shown in human beings by using transcranial magnetic stimulation techniques, whereby healthy patients carrying the Val66Met polymorphism in the BDNF gene exhibited significantly smaller training-induced increases in the amplitude of motor evoked potentials.103”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [103]
Cites
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works
Pascual‐Leone, Á., Nguyet, D., Cohen, L. G., Brasil-Neto, J. P., Cammarota, Á., & Hallett, M. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.3.1037 · Cited by 1,410 · see citing works
Rapid plasticity of human cortical movement representation induced by practice
Classen, J., Liepert, J., Wise, S. P., Hallett, M., & Cohen, L. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.1117 · Cited by 1,156 · see citing works
Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., & Weinberger, D. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06690.2003 · Cited by 1,045 · see citing works
Current Protocols in Human Genetics
Schutte, B. C., & Murray, J. C. (2001) · John Wiley & Sons, Inc. eBooks · doi:10.1002/0471142905 · Cited by 993 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2680-04.2004 · Cited by 890 · see citing works
Current protocols in human genetics
Bates, G. P. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89147-7 · Cited by 484 · see citing works
Zakharenko, S. S., Patterson, S. L., Dragatsis, I., Zeitlin, S. O., Siegelbaum, S. A., Kandel, E. R., & Morozov, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00543-9 · Cited by 334 · see citing works
Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331 · see citing works
In Search of the Motor Engram: Motor Map Plasticity as a Mechanism for Encoding Motor Experience
Monfils, M., Plautz, E. J., & Kleim, J. A. (2005) · The Neuroscientist · doi:10.1177/1073858405278015 · Cited by 315 · see citing works
Self-citationMotor Enrichment and the Induction of Plasticity Before or After Brain Injury
Kleim, J. A., Jones, T. A., & Schallert, T. J. (2003) · Neurochemical Research · doi:10.1023/a:1026025408742 · Cited by 309 · see citing works
Self-citationKlintsova, A. Y., Dickson, E., Yoshida, R., & Greenough, W. T. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.003 · Cited by 200 · see citing works
Association between BDNF val66 met genotype and episodic memory
Dempster, E. L., Toulopoulou, T., McDonald, C., Bramon, E., Walshe, M., Filbey, F. M., Wickham, H., Sham, P. C., Murray, R. M., & Collier, D. A. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30150 · Cited by 179 · see citing works
Wolf, S. L., Butler, A. J., Campana, G. I., et al. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.02.027 · Cited by 107 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938 · see citing works
The Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930 · see citing works
Neuroplasticity Subserving Motor Skill Learning
Dayan, E., & Cohen, L. G. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.008 · Cited by 1,408 · see citing works
Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., Cohen, L. G., & Lu, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.035 · Cited by 1,420 · see citing works
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
BDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043 · see citing works
Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21393 · Cited by 875 · see citing works
Self-citationRidding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787 · see citing works
Neuroplasticity in the context of motor rehabilitation after stroke
Dimyan, M. A., & Cohen, L. G. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.200 · Cited by 732 · see citing works
Physiology of repetitive transcranial magnetic stimulation of the human brain
Hoogendam, J. M., Ramakers, G. M. J., & Di Lazzaro, V. (2010) · Brain Stimulation · doi:10.1016/j.brs.2009.10.005 · Cited by 669 · see citing works
Early Rehabilitation After Stroke: a Narrative Review
Coleman, E. R., Moudgal, R., Lang, K., Hyacinth, H. I., Awosika, O. O., Kissela, B. M., & Feng, W. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0686-6 · Cited by 424 · see citing works
Brain-derived neurotrophic factor: role in depression and suicide
Dwivedi, Y. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5700 · Cited by 355 · see citing works
Long-term potentiation and long-term depression: a clinical perspective
Bliss, T. V. P., & Cooke, S. F. (2011) · Clinics · doi:10.1590/s1807-59322011001300002 · Cited by 333 · see citing works
Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333 · see citing works
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works
Integrity of white matter in the corpus callosum correlates with bimanual co-ordination skills
Johansen-Berg, H., Della-Maggiore, V., Behrens, T. E. J., Smith, S. M., & Paus, T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.041 · Cited by 272 · see citing works
Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy
Cideciyan, A. V. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.04.002 · Cited by 256 · see citing works
Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?
Demirtas-Tatlidede, A., Vahabzadeh-Hagh, A. M., & Pascual-Leone, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.020 · Cited by 236 · see citing works
Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles
Baba, M., Itaka, K., Kondo, K., Yamasoba, T., & Kataoka, K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.01.017 · Cited by 109 · see citing works
Caulfield, K. A., Fleischmann, H. H., George, M. S., & McTeague, L. M. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.06.038 · Cited by 99 · see citing works
Involvement of Brain-Derived Neurotrophic Factor in Late-Life Depression
Dwivedi, Y. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.026 · Cited by 86 · see citing works
BDNF Polymorphism and Differential rTMS Effects on Motor Recovery of Stroke Patients
Chang, W. H., Bang, O. Y., Shin, Y.-I., Lee, A., Pascual-Leone, A., & Kim, Y.-H. (2014) · Brain Stimulation · doi:10.1016/j.brs.2014.03.008 · Cited by 77 · see citing works
Chen, L., Pan, H., Tuan, T. A., Teh, A. L., MacIsaac, J. L., Mah, S. M., McEwen, L. M., Li, Y., Chen, H., Broekman, B. F. P., et al. (2015) · Development and Psychopathology · doi:10.1017/s0954579414001357 · Cited by 75 · see citing works
Genetic Modulation of Transcranial Direct Current Stimulation Effects on Cognition
Wiegand, A., Nieratschker, V., & Plewnia, C. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00651 · Cited by 52 · see citing works
McDonnell, A. (2014) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2014.47035 · Cited by 6 · see citing works
- Authors
- Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R., & Cramer, S. C.
- Affiliations
- Malcom Randall VA Medical Center (US)
- University of California, Irvine (US)
- University of Florida (US)
- Corresponding author
- Kleim, Jeffrey A
- Venue
- Nature Neuroscience
- Published
- 2006-05-07
- Volume
- 9
- Issue
- 6
- Pages
- 735-737
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2086103057
- Cited by
- 529
- References
- 15
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 23 · 2021: 28 · 2020: 25 · 2019: 28 · 2018: 29 · 2017: 26 · 2016: 37 · 2015: 42 · 2014: 47 · 2013: 45 · 2012: 34
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (1t35ns045563-01)
- National Institute of Neurological Disorders and Stroke (NS-45563)
- National Center for Research Resources (5 M01 RR00827-29, M01RR000827)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- BDNF Val66Met polymorphism, brain-derived neurotrophic factor, experience-dependent plasticity, motor cortex, motor training, motor evoked potentials, genetic polymorphism
- MeSH terms
- Adult, Brain Mapping, Female, Genotype, Humans, Learning, Male, Methionine, Motor Cortex, Motor Skills, Movement, Nerve Regeneration, Neuronal Plasticity, Neuropsychological Tests, Polymorphism, Genetic, Valine, Evoked Potentials, Motor, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Recovery of Function, Transcranial Magnetic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review