Cited by 529Transcranial Magnetic Stimulation StudiesTactile and Sensory InteractionsMotor Control and Adaptation

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Open access
Kleim, Jeffrey A, Chan, Sheila, Pringle, Erin, Schallert, Kellan, Procaccio, Vincent, Jimenez, Richard, Cramer, Steven C·2006·Nature Neuroscience

Abstract

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

Integrity signals

Registry

Crossref · 10.1038/nn1699

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Genetic influences on corticospinal plasticity have been shown in human beings using transcranial magnetic stimulation, whereby healthy patients carrying the Val66Met polymorphism in the BDNF gene exhibited significantly smaller training-induced increases in motor evoked potential amplitude.

    “Genetic influences on corticospinal plasticity have recently been shown in human beings by using transcranial magnetic stimulation techniques, whereby healthy patients carrying the Val66Met polymorphism in the BDNF gene exhibited significantly smaller training-induced increases in the amplitude of motor evoked potentials.103”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R., & Cramer, S. C.
Affiliations
  • Malcom Randall VA Medical Center (US)
  • University of California, Irvine (US)
  • University of Florida (US)
Corresponding author
Kleim, Jeffrey A
Venue
Nature Neuroscience
Published
2006-05-07
Volume
9
Issue
6
Pages
735-737
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2086103057
Cited by
529
References
15
Citations by year
2026: 8 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 23 · 2021: 28 · 2020: 25 · 2019: 28 · 2018: 29 · 2017: 26 · 2016: 37 · 2015: 42 · 2014: 47 · 2013: 45 · 2012: 34
FWCI
13.82
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • National Institutes of Health (1t35ns045563-01)
  • National Institute of Neurological Disorders and Stroke (NS-45563)
  • National Center for Research Resources (5 M01 RR00827-29, M01RR000827)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
BDNF Val66Met polymorphism, brain-derived neurotrophic factor, experience-dependent plasticity, motor cortex, motor training, motor evoked potentials, genetic polymorphism
MeSH terms
Adult, Brain Mapping, Female, Genotype, Humans, Learning, Male, Methionine, Motor Cortex, Motor Skills, Movement, Nerve Regeneration, Neuronal Plasticity, Neuropsychological Tests, Polymorphism, Genetic, Valine, Evoked Potentials, Motor, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Recovery of Function, Transcranial Magnetic Stimulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review