Cortical HCN channels: Function, trafficking and plasticity

Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function

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Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons

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Hyperpolarization-Activated Cation Channels: From Genes to Function

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Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons

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A family of hyperpolarization-activated mammalian cation channels

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Dendritic integration of excitatory synaptic input

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Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain

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α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex

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Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons

Magee, J. C. (1999) · Nature Neuroscience · doi:10.1038/9158 · Cited by 617 · see citing works

Immunohistochemical localization of Ih channel subunits, HCN1–4, in the rat brain

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Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

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Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites

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The hyperpolarization‐activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens‐alveus interneurones.

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A Behavioral Role for Dendritic Integration

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The distribution and targeting of neuronal voltage-gated ion channels

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Introduction to temporal lobe epilepsy

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Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

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Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites

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HCN channels: Structure, cellular regulation and physiological function

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Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability

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Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

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Activity-dependent decrease of excitability in rat hippocampal neurons through increases in Ih

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Membrane properties and synaptic responses of rat striatal neurones in vitro.

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Site Independence of EPSP Time Course Is Mediated by DendriticI h in Neocortical Pyramidal Neurons

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Audiogenic Seizures Susceptibility in Transgenic Mice with Fragile X Syndrome

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Seizure-Induced Plasticity of h Channels in Entorhinal Cortical Layer III Pyramidal Neurons

Shah, M. M., Anderson, A. E., Leung, V. C. M., Lin, X., & Johnston, D. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.011 · Cited by 288 · see citing works

High I h Channel Density in the Distal Apical Dendrite of Layer V Pyramidal Cells Increases Bidirectional Attenuation of EPSPs

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A Behavioral Role for Dendritic IntegrationHCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Distal Dendrites of CA1 Pyramidal Neurons

Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., GIBBS, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., & Kandel, E. R. (2004) · Cell · doi:10.1016/s0092-8674(04)01055-4 · Cited by 274 · see citing works

Developmental Febrile Seizures Modulate Hippocampal Gene Expression of Hyperpolarization-Activated Channels in an Isoform- and Cell-Specific Manner

Brewster, A. L., Bender, R. A., Chen, Y., Dubé, C. M., Eghbal-Ahmadi, M., & Baram, T. Z. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04591.2002 · Cited by 270 · see citing works

Long-Term Potentiation in Rat Hippocampal Neurons Is Accompanied by Spatially Widespread Changes in Intrinsic Oscillatory Dynamics and Excitability

Narayanan, R., & Johnston, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.033 · Cited by 257 · see citing works

Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells

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Differential Distribution of Four Hyperpolarization-Activated Cation Channels in Mouse Brain

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Fever, febrile seizures and epilepsy

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Erratum: Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons

Magee, J. C. (1999) · Nature Neuroscience · doi:10.1038/12229 · Cited by 237 · see citing works

Progressive Dendritic HCN Channelopathy during Epileptogenesis in the Rat Pilocarpine Model of Epilepsy

Jung, S., Jones, T. D., Lugo, J. N., Sheerin, A. H., Miller, J. W., D’Ambrosio, R., Anderson, A. E., & Poolos, N. P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3605-07.2007 · Cited by 229 · see citing works

Action of the hyperpolarization-activated current ( I h ) blocker ZD 7288 in hippocampal CA1 neurons

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HCN1 Channels Constrain Synaptically Evoked Ca2+ Spikes in Distal Dendrites of CA1 Pyramidal Neurons

Tsay, D., Dudman, J. T., & Siegelbaum, S. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.11.015 · Cited by 217 · see citing works

Hyperpolarization‐activated cation channels in fast‐spiking interneurons of rat hippocampus

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Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

Santoro, B., Wainger, B. J., & Siegelbaum, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3300-04.2004 · Cited by 210 · see citing works

Plasticity of Intrinsic Excitability during Long-Term Depression Is Mediated through mGluR-Dependent Changes inIhin Hippocampal CA1 Pyramidal Neurons

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Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic Hippocampus

Bender, R. A., Soleymani, S. V., Brewster, A. L., Nguyen, S. T. T., Beck, H., Mathern, G. W., & Baram, T. Z. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06826.2003 · Cited by 204 · see citing works

HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex

Nolan, M. F., Dudman, J. T., Dodson, P. D., & Santoro, B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2358-07.2007 · Cited by 194 · see citing works

Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis

Huang, Z., Walker, M. C., & Shah, M. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1531-09.2009 · Cited by 194 · see citing works

Neuron‐restrictive silencer factor‐mediated hyperpolarization‐activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

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HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels

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Active dendrites: colorful wings of the mysterious butterflies

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Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated I h channels

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Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

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The h Channel Mediates Location Dependence and Plasticity of Intrinsic Phase Response in Rat Hippocampal Neurons

Narayanan, R., & Johnston, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0835-08.2008 · Cited by 172 · see citing works

Topographical and Synaptic Organization of the GABA‐Containing Pallidosubthalamic Projection in the Rat

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TRIP8b Splice Variants Form a Family of Auxiliary Subunits that Regulate Gating and Trafficking of HCN Channels in the Brain

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Complementary Theta Resonance Filtering by Two Spatially Segregated Mechanisms in CA1 Hippocampal Pyramidal Neurons

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Temporal synchrony and gamma-to-theta power conversion in the dendrites of CA1 pyramidal neurons

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Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function

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h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy

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Dendritic ion channel trafficking and plasticity

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Animal models of epileptogenesis

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Variability in the subcellular distribution of ion channels increases neuronal diversity

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Association with the Auxiliary Subunit PEX5R/Trip8b Controls Responsiveness of HCN Channels to cAMP and Adrenergic Stimulation

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Ionic mechanisms in the generation of subthreshold oscillations and action potential clustering in entorhinal layer II stellate neurons

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Towards an integrated view of HCN channel role in epilepsy

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Corticospinal-specific HCN expression in mouse motor cortex: Ih-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control

Sheets, P. L., Suter, B. A., Kiritani, T., Chan, C. S., Surmeier, D. J., & Shepherd, G. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00232.2011 · Cited by 117 · see citing works

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy

Shin, M., Brager, D. H., Jaramillo, T. C., Johnston, D., & Chetkovich, D. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.06.013 · Cited by 113 · see citing works

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1 Mouse Model of Fragile X Syndrome

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Voltage- and Site-Dependent Control of the Somatic Impact of Dendritic IPSPs

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Downregulation of DendriticIhin CA1 Pyramidal Neurons after LTP

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Recessive Loss-of-Function Mutation in the Pacemaker HCN2 Channel Causing Increased Neuronal Excitability in a Patient with Idiopathic Generalized Epilepsy

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Increased seizure severity and seizure‐related death in mice lacking HCN1 channels

Santoro, B., Lee, J. Y., Englot, D. J., Gildersleeve, S. S., Piskorowski, R. A., Siegelbaum, S. A., Winawer, M. R., & Blumenfeld, H. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02554.x · Cited by 93 · see citing works

Prefrontal Cortex HCN1 Channels Enable Intrinsic Persistent Neural Firing and Executive Memory Function

Thuault, S., Malleret, G., Constantinople, C. M., Nicholls, R. E., Chen, I., Zhu, J., Panteleyev, A. A., Vronskaya, S., Nolan, M. F., Bruno, R. M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2427-12.2013 · Cited by 91 · see citing works

Downregulation of Dendritic HCN Channel Gating in Epilepsy Is Mediated by Altered Phosphorylation Signaling

Jung, S., Bullis, J. B., Lau, I. H., Jones, T. D., Warner, L. N., & Poolos, N. P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1290-10.2010 · Cited by 87 · see citing works

HCN channels in behavior and neurological disease: Too hyper or not active enough?

Lewis, A. S., & Chetkovich, D. M. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.007 · Cited by 86 · see citing works

TRIP8b Regulates HCN1 Channel Trafficking and Gating through Two Distinct C-Terminal Interaction Sites

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TRIP8b Splice Forms Act in Concert to Regulate the Localization and Expression of HCN1 Channels in CA1 Pyramidal Neurons

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Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation

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Preferential localization of the hyperpolarization‐activated cyclic nucleotide‐gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum

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Upregulated H-Current in hyperexcitable CA1 dendrites after febrile seizures

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Rapid Loss of Dendritic HCN Channel Expression in Hippocampal Pyramidal Neurons following Status Epilepticus

Jung, S., Warner, L. N., Pitsch, J., Becker, A. J., & Poolos, N. P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1148-11.2011 · Cited by 69 · see citing works

Trafficking and Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels Are Regulated by Interaction with Tetratricopeptide Repeat-containing Rab8b-interacting Protein (TRIP8b) and Cyclic AMP at Distinct Sites

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Selective Participation of Somatodendritic HCN Channels in Inhibitory But Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus

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Ih-mediated depolarization enhances the temporal precision of neuronal integration

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Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner

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Different levels of Ih determine distinct temporal integration in bursting and regular‐spiking neurons in rat subiculum

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Functional presynaptic HCN channels in the rat globus pallidus

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Hyperpolarization‐activated cation currents in human epileptogenic neocortex

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TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels

Huang, Z., Luján, R., Hernández, J. M., Lewis, A. S., Chetkovich, D. M., & Shah, M. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-12.2012 · Cited by 41 · see citing works

Contributions of I h to feature selectivity in layer II stellate cells of the entorhinal cortex

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Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

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Regulation of Axonal HCN1 Trafficking in Perforant Path Involves Expression of Specific TRIP8b Isoforms

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Febrile convulsions: a 'benign' condition?

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Acute alcohol and chronic drinking bidirectionally regulate the excitability of prefrontal cortex vasoactive intestinal peptide interneurons

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HCN channels segregate stimulation‐evoked movement responses in neocortex and allow for coordinated forelimb movements in rodents

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SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current

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The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster

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Reduced Synaptic Transmission and Intrinsic Excitability of a Subtype of Pyramidal Neurons in the Medial Prefrontal Cortex in a Mouse Model of Alzheimer’s Disease

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Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron

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Adolescent Stress Confers Resilience to Traumatic Stress Later in Life: Role of the Prefrontal Cortex

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Dentate Granule Cells Recruited in the Home Environment Display Distinctive Properties

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Unilateral ephaptic program underlying sweetness dominancePreprint

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Intrinsic Excitability in Layer IV–VI Anterior Insula to Basolateral Amygdala Projection Neurons Correlates with the Confidence of Taste Valence Encoding

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HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats

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Photodynamic Modification of Native HCN Channels Expressed in Thalamocortical Neurons

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Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Currents in NeuronsPreprint

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The test–retest reliability of large and small fiber nerve excitability testing with threshold tracking

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Regional Specialization of Pyramidal Neuron Morphology and Physiology in the Tree Shrew Neocortex

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Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

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The HCN Channel Blocker ZD7288 Induces Emesis in the Least Shrew (Cryptotis parva)

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Loss of HCN2 in Dorsal Hippocampus of Young Adult Mice Induces Specific Apoptosis of the CA1 Pyramidal Neuron Layer

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Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons

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Neuronal HCN channel function and plasticity

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Trafficking and Surface Expression of Hyperpolarization-activated Cyclic Nucleotide-gated Channels in Hippocampal Neurons

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Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons

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TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels

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HCN channels

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