In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy
Open accessAbstract
We develop a superficial diffusing probe with a 3 mm source-detector separation that can be used in combination with diffuse optical spectroscopic (DOS) methods to noninvasively determine full-spectrum optical properties of superficial in vivo skin in the wavelength range from 650 to 1000 nm. This new probe uses a highly scattering layer to diffuse photons emitted from a collimated light source and relies on a two-layer diffusion model to determine tissue absorption coefficient µa and reduced scattering coefficient µ. By employing the probe to measure two-layer phantoms that mimic the optical properties of skin, we demonstrate that the probe has an interrogation depth of 1 to 2 mm. We carry out SSFDPM (steady state frequency-domain photon migration) measurements using this new probe on the volar forearm and palm of 15 subjects, including five subjects of African descent, five Asians, and five Caucasians. The optical properties of in vivo skin determined using the superficial diffusing probe show considerable similarity to published optical properties of carefully prepared ex vivo epidermis+dermis.
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Inaccurate PPG heart rate measurements occur up to 15% more frequently in dark skin than in light skin.
“previous research demonstrated that inaccurate PPG HR measurements occur up to 15% more frequently in dark skin as compared to light skin”
From Investigating sources of inaccuracy in wearable optical heart rate sensors (2020) · cites this paper as [24]
Darker skin contains more melanin, which absorbs more green light than lighter skin.
“likely because darker skin contains more melanin which absorbs more green light than lighter skin.”
From Investigating sources of inaccuracy in wearable optical heart rate sensors (2020) · cites this paper as [24]
Optical heart rate measurements primarily measure green light absorption.
“since optical HR measurements primarily measure green light absorption.24,25”
From Investigating sources of inaccuracy in wearable optical heart rate sensors (2020) · cites this paper as [24]
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Investigating sources of inaccuracy in wearable optical heart rate sensors
Bent, B., Goldstein, B. A., Kibbe, W. A., & Dunn, J. P. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0226-6 · Cited by 673 · see citing works
“Difference in green light mean absorption for different skin tones during activity was used to calculate effect size since optical HR measurements primarily measure green light absorption.(24,25) Based on the ANOVA power calculation, we required eight participants per skin tone category (6 skin tone categories on FP s…”
MethodChromophore concentrations, absorption and scattering properties of human skin in-vivo
Tseng, S.-H., Bargo, P., Durkin, A., & Kollias, N. (2009) · Optics Express · doi:10.1364/oe.17.014599 · Cited by 217 · see citing works
Self-citationShimojo, Y., Nishimura, T., Hazama, H., Ozawa, T., & Awazu, K. (2020) · Journal of Biomedical Optics · doi:10.1117/1.jbo.25.4.045002 · Cited by 132 · see citing works
Jonasson, H., Fredriksson, I., Bergstrand, S., Östgren, C. J., Larsson, M., & Strömberg, T. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.12.121608 · Cited by 52 · see citing works
Hsu, C.-K., Tzeng, S.-Y., Yang, C.-C., Lee, J. Y.-Y., Huang, L. L.-H., Chen, W.-R., Hughes, M., Chen, Y.-W., Liao, Y.-K., & Tseng, S.-H. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.000390 · Cited by 45 · see citing works
Self-citationPhan, T., Rowland, R., Ponticorvo, A., Le, B. C., Wilson, R. H., Sharif, S. A., Kennedy, G. T., Bernal, N. P., & Durkin, A. J. (2021) · Journal of Biomedical Optics · doi:10.1117/1.jbo.26.2.026001 · Cited by 38 · see citing works
Self-citationHung, C.-H., Chou, T.-C., Hsu, C.-K., & Tseng, S.-H. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.000443 · Cited by 8 · see citing works
Self-citation
- Authors
- Tseng, S.-H., Grant, A., & Durkin, A. J.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Durkin, Anthony J.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2008-01-01
- Volume
- 13
- Issue
- 01
- Pages
- 1-7
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- PMC
- PMC2626348
- OpenAlex
- W2108489044
- Cited by
- 139
- References
- 0
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 15 · 2015: 11 · 2014: 1 · 2013: 8 · 2012: 5
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biomedical Optics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Arnold and Mabel Beckman Foundation
- National Institutes of Health (RR-01192))
- U.S. Air Force (FA9550)
- National Center for Research Resources (P41 RR01192, P41RR001192)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Keywords
- skin optical properties, near-infrared spectroscopy, diffuse optical spectroscopy, source-detector separation, tissue absorption coefficient, reduced scattering coefficient, skin phantom, volar forearm, palm skin, epidermis and dermis
- MeSH terms
- Algorithms, Computer Simulation, Humans, Infrared Rays, Models, Biological, Photometry, Sensitivity and Specificity, Skin Physiological Phenomena, Reproducibility of Results, Spectroscopy, Near-Infrared, Dermoscopy
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