In vivo characterization of light scattering properties of human skin in the 475- to 850-nm wavelength range in a Swedish cohort
Open accessAbstract
We have determined in vivo optical scattering properties of normal human skin in 1734 subjects, mostly with fair skin type, within the Swedish CArdioPulmonary bioImage Study. The measurements were performed with a noninvasive system, integrating spatially resolved diffuse reflectance spectroscopy and laser Doppler flowmetry. Data were analyzed with an inverse Monte Carlo algorithm, accounting for both scattering, geometrical, and absorbing properties of the tissue. The reduced scattering coefficient was found to decrease from 3.16 ± 0.72 to 1.13 ± 0.27 mm−1 (mean ± SD) in the 475- to 850-nm wavelength range. There was a negative correlation between the reduced scattering coefficient and age, and a significant difference between men and women in the reduced scattering coefficient as well as in the fraction of small scattering particles. This large study on tissue scattering with mean values and normal variation can serve as a reference when designing diagnostic techniques or when evaluating the effect of therapeutic optical systems.
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The maximum sample number for FST V-VI is 6.
“the maximum sample number for FST V–VI is 6.41,42,44,46,48”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [48]
As age increased the reduced scattering coefficient decreased.
“As age increased the reduced scattering coefficient decreased”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [61]
Measured reduced scattering coefficients have up to 10-fold variability using DRS at 700 nm, ranging from 0.184 mm-1 to 2.19 mm-1.
“Similarly, measured reduced scattering coefficients have up to 10-fold variability using DRS at this wavelength, ranging from 0.184 mm-1 to 2.19 mm-1 [55,57,60,61].”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [61]
Jonasson et al. found that reduced scattering coefficient decreased in the spectrum of 475 nm - 850 nm from 3.16 mm−1 to 1.13 mm−1.
“The reduced scattering coefficient decreased in the spectrum of 475 nm - 850 nm from 3.16 mm−1 to 1.13 mm−1.”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [61]
Jonasson et al. found a significant difference between men and women; measured reduced scattering coefficients were greater in men than women across the spectrum measured.
“there was a significant difference between men and women; measured reduced scattering coefficients were greater in men than women across the spectrum measured.”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [61]
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- Authors
- Jonasson, H., Fredriksson, I., Bergstrand, S., Östgren, C. J., Larsson, M., & Strömberg, T.
- Affiliations
- Linköping University (SE)
- Linköping Univ.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2018-09-28
- Volume
- 23
- Issue
- 12
- Pages
- 1-6
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- OpenAlex
- W2893672676
- Cited by
- 52
- References
- 31
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 5
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Biomedical Optics (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DiVA (Linkoping University) (submittedVersion, other-oa)
- Funders
- Swedish Heart and Lung Foundation
- Knut och Alice Wallenbergs Stiftelse
- The Swedish Research Council, Vetenskapsrådet
- VINNOVA (2016-02211)
- Sweden’s Innovation Agency (2016-02211)
- Sweden’s innovation agency VINNOVA (2016-02211)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- skin optical properties, light scattering, reduced scattering coefficient, human skin, laser Doppler flowmetry, inverse Monte Carlo, age-related changes, sex differences, fair skin, reference values
- MeSH terms
- Algorithms, Diagnostic Imaging, Female, Humans, Light, Male, Middle Aged, Monte Carlo Method, Reference Values, Scattering, Radiation, Skin, Sweden, Cohort Studies, Laser-Doppler Flowmetry, Optics and Photonics, Optical Devices
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