The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Quantitation and mapping of tissue optical properties using modulated imaging
Open accessAbstract
We describe the development of a rapid, noncontact imaging method, modulated imaging (MI), for quantitative, wide-field characterization of optical absorption and scattering properties of turbid media. MI utilizes principles of frequency-domain sampling and model-based analysis of the spatial modulation transfer function (s-MTF). We present and compare analytic diffusion and probabilistic Monte Carlo models of diffuse reflectance in the spatial frequency domain. Next, we perform MI measurements on tissue-simulating phantoms exhibiting a wide range of l values (0.5 mm to 3 mm) and (micro(s) (')micro(a)) ratios (8 to 500), reporting an overall accuracy of approximately 6% and 3% in absorption and reduced scattering parameters, respectively. Sampling of only two spatial frequencies, achieved with only three camera images, is found to be sufficient for accurate determination of the optical properties. We then perform MI measurements in an in vivo tissue system, demonstrating spatial mapping of the absorption and scattering optical contrast in a human forearm and dynamic measurements of a forearm during venous occlusion. Last, metrics of spatial resolution are assessed through both simulations and measurements of spatially heterogeneous phantoms.
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Cited by
Image-Guided Surgery Using Invisible Near-Infrared Light: Fundamentals of Clinical Translation
Gioux, S., Choi, H. S., & Frangioni, J. V. (2010) · Molecular Imaging · doi:10.2310/7290.2010.00034 · Cited by 599
Saager, R. B., Balu, M., Crosignani, V., Sharif, A., Durkin, A. J., Kelly, K. M., & Tromberg, B. J. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.6.066005 · Cited by 76
Self-citationIn Vivo Measurement of Optical Properties of Human Skin for 450–800 nm and 950–1600 nm Wavelengths
Kono, T., & Yamada, J. (2019) · International Journal of Thermophysics · doi:10.1007/s10765-019-2515-3 · Cited by 62
Jonasson, H., Fredriksson, I., Bergstrand, S., Östgren, C. J., Larsson, M., & Strömberg, T. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.12.121608 · Cited by 52
Setchfield, K., Gorman, A., Simpson, A. H. R. W., Somekh, M. G., & Wright, A. J. (2023) · Biomedical Optics Express · doi:10.1364/boe.493588 · Cited by 49
Metadata
- Authors
- Cuccia, D. J., Bevilacqua, F., Durkin, A. J., Ayers, F. R., & Tromberg, B. J.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2009
- Volume
- 14
- Issue
- 2
- Pages
- 024012
- ISSN
- 1083-3668 (ISSN-L)
- OpenAlex
- W2136708034
- Cited by
- 655
- References
- 25
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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