The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Measurement of absorption and reduced scattering coefficients in Asian human epidermis, dermis, and subcutaneous fat tissues in the 400- to 1100-nm wavelength range for optical penetration depth and energy deposition analysis
Open accessAbstract
Significance: In laser therapy and diagnosis of skin diseases, the irradiated light distribution, which is determined by the absorption coefficient μa and reduced scattering coefficient μs′ of the epidermis, dermis, and subcutaneous fat, affects the treatment outcome and diagnosis accuracy. Although values for μa and μs′ have been reported, detailed analysis for Asian skin tissues is still lacking. Aim: We present μa and μs′ measurements of Asian skin tissues in the 400- to 1100-nm wavelength range for evaluating optical penetration depth and energy deposition. Approach: The measurements with Asian human skin samples are performed employing a double integrating sphere spectrometric system and an inverse Monte Carlo technique. Using the measured parameters, the optical penetration depth and energy deposition are quantitatively analyzed. Results: The μa of the epidermis layer varies among different ethnic groups, while the μa of the other layers and the μs′ of all of the layers exhibit almost no differences. The analysis reveals that the optical penetration depth and the energy deposition affect the photodynamic therapy treatment depth and the heat production in skin tissue, respectively. Conclusions: The experimentally measured values of μa and μs′ for Asian skin tissues are presented, and the light behavior in Asian skin tissues is analyzed using a layered tissue model.
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In the citing paper
“Scattering and absorption in the skin tend to decrease with increasing wavelength.27–29”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [29]
In the citing paper
“At 405 - 532 nm, the light penetrates to a maximum depth of ∼0.3 mm reaching the upper part of dermis [53].”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [53]
In the citing paper
“At the wavelength spectrum of 405 nm - 1064 nm, absorption ranged from 3.32 mm-1 - 0.13 mm-1 and reduced scattering ranged from 9.95 mm-1 - 2.85 mm-1 in the epidermis (standard deviations for both coefficients tended to reduce with increasing wavelength).”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [53]
In the citing paper
“Peak absorption and scattering coefficients for all skin layers was at 405 nm steadily reducing with increasing wavelength with the greatest absorption and scattering coefficients being in the epidermis.”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [53]
In the citing paper
“Beyond 980 nm, light has the potential to penetrate the subcutaneous tissue travelling a distance of ∼1.65 mm.”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [53]
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Metadata
- Authors
- Shimojo, Y., Nishimura, T., Hazama, H., Ozawa, T., & Awazu, K.
- Affiliations
- The University of Osaka (JP)
- Osaka City University (JP)
- Corresponding author
- Shimojo, Yu
- Nishimura, Takahiro
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2020-04-30
- Volume
- 25
- Issue
- 04
- Pages
- 1-14
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- PMC
- PMC7191311
- OpenAlex
- W3023157917
- Cited by
- 132
- References
- 39
- Citations by year
- 2026: 20 · 2025: 29 · 2024: 26 · 2023: 21 · 2022: 19 · 2021: 13 · 2020: 4
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Biomedical Optics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- JSPS KAKENHI (19K22966, 19K12822)
- Japan Society for the Promotion of Science (19K22966, 19K12822)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- absorption coefficient, reduced scattering coefficient, Asian skin, human epidermis, dermis, subcutaneous adipose tissue, optical penetration depth, energy deposition, photodynamic therapy, laser therapy, skin diseases, inverse Monte Carlo, layered tissue model, wavelength dependence
- MeSH terms
- Epidermis, Humans, Monte Carlo Method, Scattering, Radiation, Dermis, Subcutaneous Fat
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