Suprachoroidal drug delivery to the back of the eye using hollow microneedles
Open accessAbstract
Purpose In this work, we tested the hypothesis that microneedles provide a minimally invasive method to inject particles into the suprachoroidal space for drug delivery to the back of the eye.Methods A single, hollow microneedle was inserted into the sclera, and infused nanoparticle and microparticle suspensions into the suprachoroidal space. Experiments were performed on whole rabbit, pig, and human eyes ex vivo. Particle delivery was imaged using brightfield and fluorescence microscopy as well as microcomputed tomography.Results Microneedles were shown to deliver sulforhodamine B as well as nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig, and human eyes. Volumes up to 35 μL were administered consistently. Optimization of the delivery device parameters showed that microneedle length, pressure, and particle size played an important role in determining successful delivery into the suprachoroidal space. Needle lengths of 800-1,000 μm and applied pressures of 250-300 kPa provided most reliable delivery.Conclusions Microneedles were shown for the first time to deliver nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig and human eyes. This shows that microneedles may provide a minimally invasive method for controlled drug delivery to the back of the eye.
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Suprachoroidal injection has been successful in large-animal models and was demonstrated to be a safer approach in a phase 3 clinical trial to treat uveitis with macular edema.
“This method has been successful in large-animal models and was demonstrated to be a safer approach in a phase 3 clinical trial to treat uveitis with macular edema [20,21].”
From The Ocular Gene Delivery Landscape (2021) · cites this paper as [20]
The suprachoroidal route allows for rapid dissemination of a small amount of agent around most of the eye.
“Its structural continuity and small volume are important for understanding the potential of the suprachoroidal space as a drug delivery route, which allows for rapid dissemination of a small amount of agent around most of the eye [305].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [305]
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- Authors
- Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R.
- Affiliations
- Georgia Institute of Technology (US)
- Emory University (US)
- Corresponding author
- Edelhauser, Henry F.
- Prausnitz, Mark R.
- Venue
- Pharmaceutical Research
- Published
- 2010-09-21
- Volume
- 28
- Issue
- 1
- Pages
- 166-176
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- PMC
- PMC3038673
- OpenAlex
- W1977812165
- Cited by
- 330
- References
- 27
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 30 · 2023: 24 · 2022: 17 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 19 · 2017: 22 · 2016: 25 · 2015: 19 · 2014: 14 · 2013: 13 · 2012: 16
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R24EY017045)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- hollow microneedles, nanoparticle delivery, microparticle delivery, sclera, sulforhodamine B, injection pressure, needle length, particle size
- MeSH terms
- Animals, Choroid, Drug Carriers, Pharmaceutical Preparations, Humans, Intraocular Pressure, Microinjections, Microscopy, Fluorescence, Needles, Rabbits, Retina, Sclera, Swine, Drug Delivery Systems, Nanoparticles, Injections, Intraocular, In Vitro Techniques
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