Acetylcholine Receptor (AChR) α5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces (α4β2)2α5 AChR Function
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Genomic studies have identified a D398N variation in the α5 subunit of nicotinic acetylcholine receptors (AChRs) that increases risk of nicotine dependence and lung cancer. (α4β2)₂α5 AChRs are a significant brain presynaptic subtype in brain. Their high sensitivity to activation by nicotine and high Ca²+ permeability give them substantial functional impact. α3β4* and α3β2* AChRs are predominant postsynaptic AChRs in the autonomic nervous system, but rare in brain. The amino acid 398 of α5 is located in the large cytoplasmic domain near the amphipathic α helix preceding the M4 transmembrane domain. These helices have been shown to influence AChR conductance by forming portals to the central channel. We report that α5 Asn 398 lowers Ca²+ permeability and increases short-term desensitization in (α4β2)₂α5 but not in (α3β4)₂α5 or (α3β2)₂α5 AChRs. This suggests that a positive allosteric modulator would augment nicotine replacement therapy for those with this risk variant. α5 D398N variation does not alter sensitivity to activation. The high sensitivity to activation and desensitization of (α4β2)₂α5 AChRs by nicotine results in a narrow concentration range in which activation and desensitization curves overlap. This region centers on 0.2 μM nicotine, a concentration typically sustained in smokers. This concentration would desensitize 60% of these AChRs and permit smoldering activation of the remainder. The low sensitivity to activation and desensitization of (α3β4)₂α5 AChRs by nicotine results in a broad region of overlap centered near 10 μM. Thus, at the nicotine concentrations in smokers, negligible activation or desensitization of this subtype would occur.
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The impact of the mutation defining the risk allele has been validated repeatedly in vitro and in animal models.
“The impact of the mutation that defines the risk allele has been validated repeatedly in vitro and in animal models (Kuryatov et al. 2011; Morel et al. 2014).”
From Nicotine Withdrawal (2015) · cites this paper as Kuryatov et al. 2011
The Introduction identifies D398N as the risk variant, and the Results and Table 1 report functional effects measured in expressed receptors and oocytes, supporting the in vitro part of the claim. The cited paper does not report validation of this mutation in an animal model, so it does not support that part of the sentence. (LLM, conf=0.86)
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., et al. (2008) · Nature · doi:10.1038/nature06846 · Cited by 1,523 · see citing works
Amos, C. I., Wu, X., Broderick, P., Gorlov, I. P., Gu, J., Eisen, T., Dong, Q., Zhang, Q., Gu, X., Vijayakrishnan, J., et al. (2008) · Nature Genetics · doi:10.1038/ng.109 · Cited by 1,310 · see citing works
Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature · doi:10.1038/nature06885 · Cited by 1,275 · see citing works
Variants in Nicotinic Receptors and Risk for Nicotine Dependence
Bierut, L. J., Stitzel, J. A., Wang, J. C., Hinrichs, A. L., Grucza, R. A., Xuei, X., Saccone, N. L., Saccone, S. F., Bertelsen, S., Fox, L., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111711 · Cited by 648 · see citing works
Pharmacology of Nicotine: Addiction and Therapeutics
Benowitz, N. L. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.003121 · Cited by 589 · see citing works
α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking
Berrettini, W., Yuan, X., Tozzi, F., Song, K., Francks, C., Chilcoat, H., Waterworth, D., Muglia, P., & Mooser, V (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002154 · Cited by 465 · see citing works
Self-citationHurst, R. S., Hajós, M., Raggenbass, M., Wall, T. M., Higdon, N. R., Lawson, J. A., Rutherford-Root, K. L., Berkenpas, M. B., Hoffmann, W. E., Piotrowski, D. W., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5269-04.2005 · Cited by 447 · see citing works
Samochocki, M., Höffle‐Maas, A., Fehrenbacher, A., Jostock, R., Ludwig, J., Christner, C., Radina, M., Zerlin, M., Ullmer, C., Pereira, E. F. R., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045773 · Cited by 345 · see citing works
Phasic acetylcholine release and the volume transmission hypothesis: time to move on
Sarter, M. F., Parikh, V., & Howe, W. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2635 · Cited by 340 · see citing works
Pons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., & Fratta, W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-08.2008 · Cited by 312 · see citing works
Salas, R., Sturm, R., Boulter, J., & De Biasi, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4934-08.2009 · Cited by 310 · see citing works
Xu, W., Gelber, S. E., Orr‐Urtreger, A., Armstrong, D. L., Lewis, R. A., Ou, C., Patrick, J. W., Role, L. W., Biasi, M. D., & Beaudet, A. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5746 · Cited by 287 · see citing works
Heterogeneity and complexity of native brain nicotinic receptors
Gotti, C., Moretti, M., Gaimarri, A., Zanardi, A., Clementi, F., & Zoli, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.05.023 · Cited by 282 · see citing works
Nicotine acts as a pharmacological chaperone to up-regulate human α4β2 acetylcholine receptors
Kuryatov, A., Luo, J., Cooper, J., & Lindstrom, J. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012419 · Cited by 275 · see citing works
Self-citationWeiss, R. B., Baker, T. B., Cannon, D. S., von Niederhausern, A., Dunn, D. M., Matsunami, N., Singh, N. A., Baird, L., Coon, H., McMahon, W. M., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000125 · Cited by 271 · see citing works
Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Young, G. T., Zwart, R., Walker, A., Sher, E., & Millar, N. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804372105 · Cited by 262 · see citing works
Allosteric modulation of nicotinic acetylcholine receptors
Bertrand, D., & Gopalakrishnan, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.011 · Cited by 256 · see citing works
Gerzanich, V., Wang, F., Kuryatov, A., & Lindstrom, J. M. (1998) · PubMed · Cited by 242 · see citing works
Self-citationSaccone, N. L., Saccone, S. F., Hinrichs, A. L., Stitzel, J. A., Duan, W., Pergadia, M. L., Agrawal, A., Breslau, N., Grucza, R. A., Hatsukami, D., et al. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30828 · Cited by 215 · see citing works
Tapia, L., Kuryatov, A., & Lindstrom, J. M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030445 · Cited by 196 · see citing works
Self-citationRoles of Accessory Subunits in α4β2* Nicotinic Receptors
Kuryatov, A., Onksen, J., & Lindstrom, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046789 · Cited by 195 · see citing works
Self-citationWang, F., Nelson, M. E., Kuryatov, A., Olale, F., Cooper, J., Keyser, K., & Lindstrom, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28721 · Cited by 187 · see citing works
Self-citationWang, J. C. C., Cruchaga, C., Saccone, N. L., Bertelsen, S. E., Liu, P., Budde, J., Duan, W., Fox, L. W., Grucza, R. A., Kern, J., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp231 · Cited by 187 · see citing works
Human α4β2 Acetylcholine Receptors Formed from Linked Subunits
Zhou, Y., Nelson, M. E., Kuryatov, A., Choi, C., Cooper, J., & Lindstrom, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09004.2003 · Cited by 174 · see citing works
Self-citationJackson, K. J., Marks, M. J., Vann, R. E., Chen, X., Gamage, T. F., Warner, J. A., & Damaj, M. I. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.165738 · Cited by 156 · see citing works
Haplotype Mapping of a Diploid Non-Meiotic Organism Using Existing and Induced Aneuploidies
Legrand, M., Forche, A., Selmecki, A. M., Chan, C., Kirkpatrick, D. T., & Berman, J. G. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0040001 · Cited by 153 · see citing works
The Nicotinic Acetylcholine Receptor 5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
Bailey, C. D. C., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-10.2010 · Cited by 146 · see citing works
Mao, D., Perry, D. C., Yasuda, R. P., Wolfe, B. B., & Kellar, K. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05011.x · Cited by 133 · see citing works
Gerzanich, V., Wang, F., Kuryatov, A., & Lindstrom, J. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37589-5 · Cited by 129 · see citing works
Self-citationHansen, S. B., & Taylor, P. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.03.067 · Cited by 115 · see citing works
Structural Mechanisms Underlying Benzodiazepine Modulation of the GABA A Receptor
Hanson, S. M., & Czajkowski, C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5727-07.2008 · Cited by 110 · see citing works
Hales, T. G., Dunlop, J. I., Deeb, T. Z., Carland, J. E., Kelley, S. P., Lambert, J. J., & Peters, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513222200 · Cited by 95 · see citing works
Brown, R. W. B., Collins, A. C., Lindstrom, J. M., & Whiteaker, P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04700.x · Cited by 88 · cited 3× · see citing works
“Their high sensitivity to activation by nicotine and high Ca2 permeability give them substantial functional impact (Brown et al., 2007; Tapia et al., 2007; Kuryatov et al., 2008; Grady et al., 2010).”
BackgroundSelf-citationMcClure‐Begley, T. D., King, N. M., Collins, A. C., Stitzel, J. A., Wehner, J. M., & Butt, C. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.052274 · Cited by 72 · see citing works
Grady, S. R., Salminen, O., McIntosh, J. M., Marks, M. J., & Collins, A. C. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9263-y · Cited by 61 · see citing works
Rush, R., Kuryatov, A., Nelson, M. E., & Lindstrom, J. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.6.1416 · Cited by 40 · see citing works
Self-citationJohn Daly’s Compound, Epibatidine, Facilitates Identification of Nicotinic Receptor Subtypes
Marks, M. J., Laverty, D. C., Whiteaker, P., Salminen, O., Grady, S. R., McIntosh, J. M., & Collins, A. C. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9264-x · Cited by 31 · see citing works
On the Origin of Ion Selectivity in the Cys-Loop Receptor Family
Sine, S. M., Wang, H.-L., Hansen, S. B., & Taylor, P. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9260-1 · Cited by 26 · see citing works
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Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
Fowler, C. D., Lu, Q., Johnson, P. M., Marks, M. J., & Kenny, P. J. (2011) · Nature · doi:10.1038/nature09797 · Cited by 663 · see citing works
Nicotinic acetylcholine receptors: From basic science to therapeutics
Hurst, R. S., Rollema, H., & Bertrand, D. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.012 · Cited by 525 · see citing works
The Genetic Basis of Addictive Disorders
Ducci, F., & Goldman, D. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.03.010 · Cited by 303 · see citing works
Williams, D. K., Wang, J., & Papke, R. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.001 · Cited by 247 · see citing works
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses
Miwa, J. M., Freedman, R., & Lester, H. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.014 · Cited by 205 · see citing works
The genetics of addiction—a translational perspective
Arpana Agrawal, A., Verweij, K. J. H., Gillespie, N. A., Heath, A. C., Lessov‐Schlaggar, C. N., Martin, N. G., Nelson, E. C., Slutske, W. S., Whitfield, J. B., & Lynskey, M. T. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.54 · Cited by 198 · see citing works
Recent advances in the genetic epidemiology and molecular genetics of substance use disorders
Kendler, K. S., Chen, X., Dick, D., Maes, H., Gillespie, N., Neale, M. C., & Riley, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3018 · Cited by 179 · see citing works
Genetic Vulnerability and Susceptibility to Substance Dependence
Bierut, L. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.015 · Cited by 176 · see citing works
McLaughlin, I., Dani, J. A., & De Biasi, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/978-3-319-13482-6_4 · Cited by 173 · see citing works
Chen, L.-S., Baker, T. B., Piper, M. E., Breslau, N., Cannon, D. S., Doheny, K. F., Gogarten, S. M., Johnson, E. O., Saccone, N. L., Wang, J. C. C., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11101545 · Cited by 143 · see citing works
Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex
Colangelo, C., Shichkova, P., Keller, D. X., Markram, H., & Ramaswamy, S. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00024 · Cited by 134 · see citing works
Acetylcholine signaling system in progression of lung cancers
Friedman, J. R., Richbart, S. D., Merritt, J. C., Brown, K. C., Nolan, N. A., Akers, A. T., Lau, J. K., Robateau, Z. R., Miles, S. L., & Dasgupta, P. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.10.002 · Cited by 124 · see citing works
Nicotine consumption is regulated by a human polymorphism in dopamine neurons
Morel, C., Fattore, L., Pons, S., Hay, Y. A., Marti, F., Lambolez, B., De Biasi, M., Lathrop, M., Fratta, W., Maskos, U., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.158 · Cited by 123 · see citing works
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 126 · see citing works
King, D. P., Paciga, S. A., Pickering, E. H., Benowitz, N. L., Bierut, L. J., Conti, D. V., Kaprio, J. A., Lerman, C. E., & Park, P. W. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.232 · Cited by 117 · see citing works
Striatal α5 Nicotinic Receptor Subunit Regulates Dopamine Transmission in Dorsal Striatum
Exley, R. A., McIntosh, J. M., Marks, M. J., Maskos, U., & Cragg, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-11.2012 · Cited by 104 · see citing works
The CHRNA5–A3–B4 gene cluster in nicotine addiction
Berrettini, W. H., & Doyle, G. A. R. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.122 · Cited by 97 · see citing works
Self-citationKuryatov, A., & Lindstrom, J. M. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.066159 · Cited by 97 · see citing works
Self-citationHsu, Y. A., Tempest, L., Quina, L. A., Wei, A. D., Zeng, H., & Turner, E. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-13.2013 · Cited by 95 · see citing works
The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to Therapeutics
Lassi, G., Taylor, A. E., Timpson, N. J., Kenny, P. J., Mather, R. J., Eisen, T., & Munafò, M. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.10.005 · Cited by 85 · see citing works
A CHRNA5 smoking risk variant decreases the aversive effects of nicotine in humans
Jensen, K. P., DeVito, E. E., Herman, A. I., Valentine, G. W., Gelernter, J., & Sofuoglu, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.131 · Cited by 85 · see citing works
Environmental, genetic and epigenetic contributions to cocaine addiction
Pierce, R. C., Fant, B., Swinford-Jackson, S. E., Heller, E. A., Berrettini, W. H., & Wimmer, M. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0008-x · Cited by 82 · see citing works
Self-citationOrthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors
Wang, J., & Lindstrom, J. M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13745 · Cited by 82 · see citing works
Self-citationChen, L., Hung, R. J., Baker, T. B., Horton, A. C., Culverhouse, R., Saccone, N. L., Cheng, I. C., Deng, B., Han, Y., Hansen, H. M., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv100 · Cited by 81 · see citing works
Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers
Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T.-H., Coon, H., Han, Y., Stephens, S. H., Sun, J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.124 · Cited by 75 · see citing works
Shi, D., Guo, W., Chen, W., Fu, L., Wang, J., Tian, Y., Xiao, X., Kang, T., Huang, W., & Deng, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043898 · Cited by 71 · see citing works
Bailey, C. D. C., Alves, N. C., Nashmi, R., De Biasi, M., & Lambe, E. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.011 · Cited by 69 · see citing works
Li, W., Jiang, K., Yuan, W., Cui, W., & Li, M. D. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8997-x · Cited by 66 · see citing works
Broms, U., Wedenoja, J., Largeau, M. R., Korhonen, T., Pitkäniemi, J. M., Keskitalo‐Vuokko, K., Häppölä, A., Heikkilä, K., Heikkila, K. V., Ripatti, S., et al. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr283 · Cited by 60 · see citing works
Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence
Haller, G., Druley, T. E., Vallania, F., Mitra, R. D., Li, P., Akk, G., Steinbach, J. H., Breslau, N., Johnson, E. O., Hatsukami, D. K., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr498 · Cited by 59 · see citing works
Nicotine Reduction: Strategic Research Plan
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Tammimäki, A., Herder, P., Li, P., Esch, C., Laughlin, J. R., Akk, G., & Stitzel, J. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.022 · Cited by 58 · see citing works
Function of Human α3β4α5 Nicotinic Acetylcholine Receptors Is Reduced by the α5(D398N) Variant
George, A. A., Lucero, L. M., Damaj, M. I., Lukas, R. J., Chen, X., & Whiteaker, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.379339 · Cited by 58 · see citing works
Grady, S. R., Wageman, C. R., Patzlaff, N. E., & Marks, M. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.026 · Cited by 56 · see citing works
Twins and the mystery of missing heritability: the contribution of gene–environment interactions
Kaprio, J. A. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02587.x · Cited by 53 · see citing works
Crucial role of nicotinic α5 subunit variants for Ca2+fluxes in ventral midbrain neurons
Sciaccaluga, M., Moriconi, C., Martinello, K., Catalano, M., Bermúdez, I., Stitzel, J. A., Maskos, U., & Fucile, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-268102 · Cited by 50 · see citing works
Anderson, S. M., & Brunzell, D. H. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13090 · Cited by 50 · see citing works
George, A. A., Bloy, A., Miwa, J. M., Lindstrom, J. M., Lukas, R. J., & Whiteaker, P. (2017) · The FASEB Journal · doi:10.1096/fj.201600733r · Cited by 48 · see citing works
Self-citationMorton, G., Nasirova, N., Sparks, D. W., Brodsky, M., Sivakumaran, S., Lambe, E. K., & Turner, E. E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0023-18.2018 · Cited by 48 · see citing works
Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement
Morel, C., Montgomery, S. E., & Han, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14160 · Cited by 45 · see citing works
Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence
Fowler, C. D., Turner, J. R., & Damaj, M. I. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_252 · Cited by 45 · see citing works
Pathways to precision medicine in smoking cessation treatments
Chen, L., Horton, A. C., & Bierut, L. J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.033 · Cited by 44 · see citing works
Chen, L.-S., Baker, T. B., Hung, R. J., Horton, A. C., Culverhouse, R., Hartz, S. M., Saccone, N. L., Cheng, I. C., Deng, B., Han, Y., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.012 · Cited by 44 · see citing works
Olfson, E., Saccone, N. L., Johnson, E. O., Chen, L.-S., Culverhouse, R., Doheny, K., Foltz, S. M., Fox, L., Gogarten, S. M., Hartz, S., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.105 · Cited by 43 · see citing works
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Forget, B., Scholze, P., Vives, F. L., Morel, C., Pons, S., Mondoloni, S., Besson, M., Cuttoli, R. D.-D., Hay, Y. A., Tricoire, L., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.08.044 · Cited by 41 · see citing works
Brunzell, D. H., McIntosh, J. M., & Papke, R. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12421 · Cited by 40 · see citing works
An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors
Wang, J., Kuryatov, A., Sriram, A., Jin, Z., Kamenecka, T. M., Kenny, P. J., & Lindstrom, J. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646786 · Cited by 40 · see citing works
Self-citationAnderson, S. M., & Brunzell, D. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048665 · Cited by 40 · see citing works
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes
Gold, A. B., & Lerman, C. E. (2012) · Human Genetics · doi:10.1007/s00439-012-1143-9 · Cited by 40 · see citing works
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen, K. P., DeVito, E. E., Valentine, G. W., Gueorguieva, R. V., & Sofuoglu, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.373 · Cited by 40 · see citing works
A glimpse into the future – Personalized medicine for smoking cessation
Bierut, L. J., Johnson, E. O., & Saccone, N. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.009 · Cited by 39 · see citing works
A Review of Genome-Wide Association Studies of Stimulant and Opioid Use Disorders
Jensen, K. P. (2016) · Complex Psychiatry · doi:10.1159/000444755 · Cited by 38 · see citing works
Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking
Stephens, S. H., Hartz, S. M., Hoft, N. R., Saccone, N. L., Corley, R., Hewitt, J. K., Hopfer, C. J., Breslau, N., Coon, H. H., Chen, X., et al. (2013) · Genetic Epidemiology · doi:10.1002/gepi.21760 · Cited by 38 · see citing works
Yang, J., & Li, M. D. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.67 · Cited by 37 · see citing works
MacQueen, D. A., Heckman, B. W., Blank, M. D., Rensburg, K. J. V., Park, J. Y., Drobes, D. J., & Evans, D. E. (2013) · The Pharmacogenomics Journal · doi:10.1038/tpj.2012.50 · Cited by 35 · see citing works
Mesolimbic Dopamine and Habenulo-Interpeduncular Pathways in Nicotine Withdrawal
Dani, J. A., & De Biasi, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012138 · Cited by 34 · see citing works
Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele
Oni, E. N., Halikere, A., Li, G., Toro-Ramos, A. J., Swerdel, M. R., Verpeut, J. L., Moore, J. C., Bello, N. T., Bierut, L. J., Goate, A., et al. (2016) · Scientific Reports · doi:10.1038/srep34341 · Cited by 32 · see citing works
Stokes, C. A., & Papke, R. L. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.035 · Cited by 34 · see citing works
Brunzell, D. H. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts089 · Cited by 32 · see citing works
Barrie, E. S., Hartmann, K., Lee, S., Frater, J. T., Seweryn, M. T., Wang, D., & Sadée, W. (2016) · Human Mutation · doi:10.1002/humu.23135 · Cited by 31 · see citing works
The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2* and α3β4* Receptors
Scholze, P., & Huck, S. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.607959 · Cited by 31 · see citing works
Ochoa, V., George, A. A., Nishi, R., & Whiteaker, P. (2015) · The FASEB Journal · doi:10.1096/fj.15-274548 · Cited by 30 · see citing works
Jain, A., Kuryatov, A., Wang, J., Kamenecka, T. M., & Lindstrom, J. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.749150 · Cited by 31 · see citing works
Self-citationCholinergic Receptors and Addiction
Papke, R. L., Brunzell, D. H., & Biasi, M. D. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_139 · Cited by 30 · see citing works
Tian, M. K., Bailey, C. D. C., Biasi, M. D., Picciotto, M. R., & Lambe, E. K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3600-11.2011 · Cited by 29 · see citing works
Saccone, N. L., Emery, L. S., Sofer, T., Gogarten, S. M., Becker, D. M., Böttinger, E. P., Chen, L.-S., Culverhouse, R., Duan, W., Hancock, D. B., et al. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx107 · Cited by 29 · see citing works
Besson, M., Forget, B., Correia, C., Blanco, R., & Maskos, U. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0462-0 · Cited by 27 · see citing works
Kuryatov, A., Mukherjee, J. T., & Lindstrom, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062246 · Cited by 27 · see citing works
Self-citationO’Neill, H. C., Laverty, D. C., Patzlaff, N. E., Cohen, B. N., Fonck, C., McKinney, S. L., McIntosh, J. M., Lindstrom, J. M., Lester, H. A., Grady, S. R., et al. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.10.014 · Cited by 27 · see citing works
Self-citationLiu, W., & Li, M. D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170801103009 · Cited by 27 · see citing works
McClure‐Begley, T. D., Papke, R. L., Stone, K. L., Stokes, C. A., Levy, A. D., Gelernter, J. E., Xie, P., Lindstrom, J. M., & Picciotto, M. R. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.209767 · Cited by 26 · see citing works
Self-citationLi, P., McCollum, M. M., Bracamontes, J. R., Steinbach, J. H., & Akk, G. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.073841 · Cited by 25 · see citing works
E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerability
Lallai, V., Manca, L., & Fowler, C. D. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103656 · Cited by 24 · see citing works
DRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory
Giorgio, A. D., Smith, R. M., Fazio, L., D’Ambrosio, E., Gelao, B., Tomasicchio, A., Selvaggi, P., Taurisano, P., Quarto, T., Masellis, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095997 · Cited by 24 · see citing works
Preparing the Way: Exploiting Genomic Medicine to Stop Smoking
Bierut, L. J., & Tyndale, R. F. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.12.001 · Cited by 24 · see citing works
Garcia‐Rivas, V., & Deroche‐Gamonet, V. (2018) · Addiction Biology · doi:10.1111/adb.12607 · Cited by 25 · see citing works
Maskos, U. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14989 · Cited by 24 · see citing works
From genes to therapeutic targets for psychiatric disorders – what to expect?
Muglia, P. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.08.003 · Cited by 23 · see citing works
Genetics of addictive behavior: the example of nicotine dependence
Gorwood, P. A. P. M., Strat, Y. L., & Ramoz, N. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.3/pgorwood · Cited by 23 · see citing works
Pérez-Páramo, Y. X., & Lazarus, P. J. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1863948 · Cited by 24 · see citing works
Hällfors, J., Loukola, A., Pitkäniemi, J. M., Broms, U., Männistö, S., Salomaa, V. V., Heliövaara, M., Lehtimäki, T. J., Raitakari, O. T., Madden, P. A. F., et al. (2013) · Europe PMC (PubMed Central) · Cited by 23 · see citing works
Ortiz, N. C., O'Neill, H. C., Marks, M. J., & Grady, S. R. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr284 · Cited by 22 · see citing works
Besson, M., Guiducci, S., Granon, S., Guilloux, J., Guiard, B. P., Repérant, C., Fauré, P., Pons, S., Cannazza, G., Zoli, M., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4362-2 · Cited by 23 · see citing works
In Vitro and Ex Vivo Analysis of CHRNA3 and CHRNA5 Haplotype Expression
Doyle, G. A. R., Wang, M., Chou, A. D., Oleynick, J. U., Arnold, S. E., Buono, R. J., Ferraro, T. N., & Berrettini, W. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023373 · Cited by 22 · see citing works
Self-citationLiu, Q., Han, H., Wang, M., Yao, Y., Li, W., Jiang, K., Ma, Y., Fan, R., Chen, J., Su, K., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0130-x · Cited by 22 · see citing works
Deflorio, C., Blanchard, S., Carisi, M. C., Bohl, D., & Maskos, U. (2016) · The FASEB Journal · doi:10.1096/fj.201600932r · Cited by 20 · see citing works
Gene-environment interaction explains a part of missing heritability in human body mass index
Jung, H., Kim, D. J., Baek, E. J., Chung, J. Y., Ha, T. W., Kim, H.-K., Kang, J., Lim, J. E., & Oh, B. (2023) · Communications Biology · doi:10.1038/s42003-023-04679-4 · Cited by 20 · see citing works
Jin, Z., Khan, P. M., Shin, Y., Wang, J., Li, L., Cameron, M. D., Lindstrom, J. M., Kenny, P. J., & Kamenecka, T. M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.11.049 · Cited by 20 · see citing works
Self-citationJia, J., Peng, J., Li, Z., Wu, Y., Qun-lin, W., Tu, W., & Wu, M. (2016) · Mediators of Inflammation · doi:10.1155/2016/4854378 · Cited by 20 · see citing works
Shorey‐Kendrick, L. E., Ford, M. M., Allen, D. C., Kuryatov, A., Lindstrom, J. M., Wilhelm, L., Grant, K. A., & Spindel, E. R. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.023 · Cited by 19 · see citing works
Self-citationAssociations between smoking behavior-related alleles and the risk of melanoma
Wu, W., Liu, H., Song, F., Chen, L.-S., Kraft, P., Wei, Q., & Han, J. (2016) · Oncotarget · doi:10.18632/oncotarget.10144 · Cited by 19 · see citing works
Dash, B., Lukas, R. J., & Li, M. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.021 · Cited by 19 · see citing works
Neonicotinic analogues: Selective antagonists for α4β2 nicotinic acetylcholine receptors
Faundez‐Parraguez, M., Farias-Rabelo, N., González-Gutiérrez, J. P., Etcheverry-Berríos, Á., Alzate‐Morales, J. H., Adasme‐Carreño, F., Varas, R., Bermúdez, I., & Iturriaga‐Vásquez, P. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.03.024 · Cited by 19 · see citing works
Experimental and Clinical Research
Mravec, B. (2024) · Springer eBooks · doi:10.1007/978-3-031-68590-3_67 · Cited by 19 · see citing works
Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors
Prevost, M. S., Bouchenaki, H., Barilone, N., Gielen, M. C., & Corringer, P. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03558-z · Cited by 17 · see citing works
Mathuru, A. S. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.030 · Cited by 17 · see citing works
Tomaz, P. R. X., Santos, J. R., Issa, J. S., Abe, T. O., Gaya, P. V., Negrão, A. B., Krieger, J. E., Pereira, A. C., & Santos, P. C. J. L. (2018) · BMC Medical Genetics · doi:10.1186/s12881-018-0571-3 · Cited by 17 · see citing works
Buczkowski, K., Siemińska, A., Linkowska, K., Czachowski, S., Przybylski, G., Jassem, E., & Grzybowski, T. (2015) · BioMed Research International · doi:10.1155/2015/350348 · Cited by 16 · see citing works
Expression of human AChR extracellular domain mutants with improved characteristics
Lazaridis, K., Zisimopoulou, P., Giastas, P., Bitzopoulou, K., Evangelakou, P., Sideri, A., & Tzartos, S. J. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.11.003 · Cited by 16 · see citing works
Wageman, C. R., Marks, M. J., & Grady, S. R. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntt146 · Cited by 16 · see citing works
- Authors
- Kuryatov, A., Berrettini, W., & Lindstrom, J.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Berrettini, Wade
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 79
- Issue
- 1
- Pages
- 119-125
- ISSN
- 0026-895X (ISSN-L)
- PMC
- PMC3014277
- OpenAlex
- W2005131991
- Cited by
- 171
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 8 · 2018: 14 · 2017: 12 · 2016: 13 · 2015: 16 · 2014: 16 · 2013: 15 · 2012: 22
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01DA030929, DA025201, R01DA025201)
- National Institute of Neurological Disorders and Stroke (NS11323, R01NS011323)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- nicotinic acetylcholine receptors, alpha5 subunit, nicotine dependence, lung cancer risk, calcium permeability, receptor desensitization, nicotine sensitivity, allosteric modulators, nicotine replacement therapy, presynaptic nicotinic receptors
- MeSH terms
- Animals, Cell Line, Female, Humans, Lung Neoplasms, Nerve Tissue Proteins, Receptors, Nicotinic, Risk Factors, Tobacco Use Disorder, Genetic Variation, Xenopus laevis, Protein Subunits
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