International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., & MacKinnon, R. (1998) · Science · doi:10.1126/science.280.5360.69 · Cited by 6,807

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

McKemy, D. D., Neuhausser, W. M., & Julius, D. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,709

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

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A TRP Channel that Senses Cold Stimuli and Menthol

Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,355

Calcium signaling

Clapham, D. E. (1995) · Cell · doi:10.1016/0092-8674(95)90408-5 · Cited by 1,959

Depletion of intracellular calcium stores activates a calcium current in mast cells

Hoth, M., & Penner, R. (1992) · Nature · doi:10.1038/355353a0 · Cited by 1,751

A capsaicin-receptor homologue with a high threshold for noxious heat

Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. (1999) · Nature · doi:10.1038/18906 · Cited by 1,603

The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway

Caterina, M. J., & Julius, D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.487 · Cited by 1,575

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,495

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

Liedtke, W., Choe, Y., Martí-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,389

Coding of Sweet, Bitter, and Umami Tastes

Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S., & Ryba, N. J. P. (2003) · Cell · doi:10.1016/s0092-8674(03)00071-0 · Cited by 1,294

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S., Jordt, S.-E., Basbaum, A. I., Chao, M. V., & Julius, D. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,258

The trp ion channel family

Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077544 · Cited by 1,153

Heat-Evoked Activation of the Ion Channel, TRPV4

Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,031

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G., & Plant, T. D. (2000) · Nature Cell Biology · doi:10.1038/35036318 · Cited by 1,023

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., et al. (2002) · Science · doi:10.1126/science.1073140 · Cited by 970

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

Nadler, M. J. S., Hermosura, M. C., Inabe, K., Perraud, A.-L., Zhu, Q., Stokes, A. J., Kurosaki, T., Kinet, J.-P., Penner, R., Scharenberg, A. M., et al. (2001) · Nature · doi:10.1038/35079092 · Cited by 922

TRPV3 is a calcium-permeable temperature-sensitive cation channel

Xu, H., Ramsey, I. S., Kotecha, S. A., Moran, M. M., Chong, J. A., Lawson, D., Ge, P., Lilly, J., Silos-Santiago, I., Xie, Y., et al. (2002) · Nature · doi:10.1038/nature00882 · Cited by 920

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

Perraud, A.-L., Fleig, A., Dunn, C. A., Bagley, L. A., Launay, P., Schmitz, C., Stokes, A. J., Zhu, Q., Bessman, M. J., Penner, R., et al. (2001) · Nature · doi:10.1038/35079100 · Cited by 892

Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2

Stowers, L., Holy, T. E., Meister, M., Dulac, C., & Koentges, G. (2002) · Science · doi:10.1126/science.1069259 · Cited by 880

The TRP Channels, a Remarkably Functional Family

Montell, C., Birnbaumer, L., & Flockerzi, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00670-0 · Cited by 877

TRPV3 is a temperature-sensitive vanilloid receptor-like protein

Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., Wright, J. E., Jerman, J. C., Walhin, J.-P., Ooi, L., et al. (2002) · Nature · doi:10.1038/nature00894 · Cited by 836

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

Schlingmann, K. P., Weber, S., Peters, M., Niemann Nejsum, L., Vitzthum, H., Klingel, K., Kratz, M., Haddad, E., Ristoff, E., Dinour, D., et al. (2002) · Nature Genetics · doi:10.1038/ng889 · Cited by 793

TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization

Launay, P., Fleig, A., Perraud, A.-L., Scharenberg, A. M., Penner, R., & Kinet, J.-P. (2002) · Cell · doi:10.1016/s0092-8674(02)00719-5 · Cited by 744

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

Strübing, C., Krapivinsky, G., Krapivinsky, L., & Clapham, D. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00240-9 · Cited by 738

TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

Runnels, L. W., Yue, L., & Clapham, D. E. (2001) · Science · doi:10.1126/science.1058519 · Cited by 733

Regulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7

Schmitz, C., Perraud, A.-L., Johnson, C. O., Inabe, K., Smith, M. K., Penner, R., Kurosaki, T., Fleig, A., & Scharenberg, A. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00556-7 · Cited by 727

Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

Birder, L. A., Nakamura, Y., Kiss, S., Nealen, M. L., Barrick, S., Kanai, A. J., Wang, E., Ruiz, G., de Groat, W. C., Apodaca, G., et al. (2002) · Nature Neuroscience · doi:10.1038/nn902 · Cited by 703

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

Zhu, X., Jiang, M., Peyton, M., Boulay, G., Hurst, R., Stefani, E., & Birnbaumer, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81233-7 · Cited by 685

TRPC1, a human homolog of a Drosophila store-operated channel.

Wes, P. D., Chevesich, J., Jeromin, A., Rosenberg, C., Stetten, G., & Montell, C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9652 · Cited by 632

Molecular Identification of the Apical Ca2+Channel in 1,25-Dihydroxyvitamin D3-responsive Epithelia

Hoenderop, J. G. J., van der Kemp, A. W. C. M., Hartog, A., van de Graaf, S. F. J., van Os, C. H., Willems, P. H. G. M., & Bindels, R. J. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8375 · Cited by 604

Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.

Tsavaler, L., Shapero, M. H., Morkowski, S., & Laus, R. (2001) · PubMed · Cited by 599

The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α1-Adrenoceptor–Activated Ca2+-Permeable Cation Channel

Inoue, R., Okada, T., Onoue, H., Hara, Y., Shimizu, S., Naitoh, S., Ito, Y., & Mori, Y. (2001) · Circulation Research · doi:10.1161/01.res.88.3.325 · Cited by 596

Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia

Walder, R. Y., Landau, D., Meyer, P., Shalev, H., Tsolia, M., Borochowitz, Z., Boettger, M. B., Beck, G. E., Englehardt, R. K., Carmi, R., et al. (2002) · Nature Genetics · doi:10.1038/ng901 · Cited by 573

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

Tsien, R. W., Hess, P., McCleskey, E. W., & Rosenberg, R. L. (1987) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.16.060187.001405 · Cited by 524

A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity

Prescott, E. D., & Julius, D. (2003) · Science · doi:10.1126/science.1083646 · Cited by 519

The TRPM7 channel is inactivated by PIP2 hydrolysis

Runnels, L. W., Yue, L., & Clapham, D. E. (2002) · Nature Cell Biology · doi:10.1038/ncb781 · Cited by 516

From worm to man: three subfamilies of TRP channels

Harteneck, C., Plant, T. D., & Schultz, G. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01532-5 · Cited by 483

Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7

Okada, T., Inoue, R., Yamazaki, K., Maeda, A., Kurosaki, T., Yamakuni, T., Tanaka, I., Shimizu, S., Ikenaka, K., Imoto, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27359 · Cited by 457

TRP2: A candidate transduction channel for mammalian pheromone sensory signaling

Liman, E. R., Corey, D. P., & Dulac, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5791 · Cited by 447

Immunocyte Ca 2+ Influx System Mediated by LTRPC2

Sano, Y., Inamura, K., Miyake, A., Mochizuki, S., Yokoi, H., Matsushime, H., & Furuichi, K. (2001) · Science · doi:10.1126/science.1062473 · Cited by 441

Hypotonicity Induces TRPV4-Mediated Nociception in Rat

Alessandri-Haber, N., Yeh, J. J., Boyd, A. E., Parada, C. A., Chen, X., Reichling, D. B., & Levine, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00462-8 · Cited by 439

Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5

Schaefer, M., Plant, T. D., Obukhov, A. G., Hofmann, T., Gudermann, T., & Schultz, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.23.17517 · Cited by 420

Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

Duncan, L. M., Deeds, J. D., Hunter, J., Shao, J., Holmgren, L. M., Woolf, E. A., Tepper, R. I., & Shyjan, A. W. (1998) · PubMed · Cited by 401

TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation Channel

Hofmann, T., Chubanov, V., Gudermann, T., & Montell, C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00431-7 · Cited by 396

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

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Impaired osmotic sensation in mice lacking TRPV4

Mizuno, A., Matsumoto, N., Imai, M., & Suzuki, M. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00559.2002 · Cited by 378

Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3

Grimm, C., Kraft, R., Sauerbruch, S., Schultz, G., & Harteneck, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300945200 · Cited by 367

Voltage Dependence of the Ca2+-activated Cation Channel TRPM4

Nilius, B., Prenen, J., Droogmans, G., Voets, T., Vennekens, R., Freichel, M., Wissenbach, U., & Flockerzi, V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305127200 · Cited by 361

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

Yue, L., Peng, J.-B., Hediger, M. A., & Clapham, D. E. (2001) · Nature · doi:10.1038/35070596 · Cited by 356

Permeation and Gating Properties of the Novel Epithelial Ca2+ Channel

Vennekens, R., Hoenderop, J. G. J., Prenen, J., Stuiver, M., Willems, P. H. G. M., Droogmans, G., Nilius, B., & Bindels, R. J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3963 · Cited by 326

Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance

Xu, X.-Z. S., Li, H.-S., Guggino, W. B., & Montell, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80302-5 · Cited by 305

Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

Okada, T., Shimizu, S., Wakamori, M., Maeda, A., Kurosaki, T., Takada, N., Imoto, K., & Mori, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10279 · Cited by 296

Coassembly of Trp1 and Trp3 Proteins Generates Diacylglycerol- and Ca2+-sensitive Cation Channels

Lintschinger, B., Balzer-Geldsetzer, M., Baskaran, T., Graier, W. F., Romanin, C., Zhu, M. X., & Groschner, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002705200 · Cited by 294

Visual Transduction in Drosophila

Montell, C. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.231 · Cited by 279

Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity

Yamaguchi, H., Matsushita, M., Nairn, A. C., & Kuriyan, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00256-8 · Cited by 278

Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca 2+ entry channel

Vannier, B., Peyton, M., Boulay, G., Brown, D., Qin, N., Jiang, M., Zhu, X., & Birnbaumer, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2060 · Cited by 277

Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain

Nagamine, K., Kudoh, J., Minoshima, S., Kawasaki, K., Asakawa, S., Ito, F., & Shimizu, N. (1998) · Genomics · doi:10.1006/geno.1998.5551 · Cited by 261

Caloramator viterbensis sp. nov., a novel thermophilic, glycerol-fermenting bacterium isolated from a hot spring in Italy

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Association of Mammalian Trp4 and Phospholipase C Isozymes with a PDZ Domain-containing Protein, NHERF

Tang, Y., Tang, J., Chen, Z., Trost, C., Flockerzi, V., Li, M., Ramesh, V., & Zhu, M. X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006635200 · Cited by 249

Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)

Lee, N., Chen, J., Sun, L., Wu, S., Gray, K. R., Rich, A., Huang, M., Lin, J.-H., Feder, J. N., Janovitz, E. B., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211232200 · Cited by 229

Predicting adaptive evolution

Bush, R. M. (2001) · Nature Reviews Genetics · doi:10.1038/35072023 · Cited by 222

Regulation of TRP Channels via Lipid Second Messengers

Hardie, R. C. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142505 · Cited by 204

Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.

Putney, J. W. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011851 · Cited by 200

Whole‐cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC

Nilius, B., Vennekens, R., Prenen, J., Hoenderop, J. G. J., Bindels, R. J. M., & DROOGMANS, G. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00239.x · Cited by 151

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

HOFMANN, T., Schaefer, M., Schultz, G., & Gudermann, T. W. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510115 · Cited by 90

12 Store-operated calcium channels

Lewis, R. S. (1999) · Advances in second messenger and phosphoprotein research · doi:10.1016/s1040-7952(99)80014-7 · Cited by 85

Calcium Absorption Across Epithelia

Hoenderop, J. G. J., Nilius, B., & Bindels, R. J. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2004 · Cited by 936

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522

2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3

Hu, H.-Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., Lee, L.-Y., Wood, J. D., & Zhu, M. X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404164200 · Cited by 517

Emerging Diversity in Lipid–Protein Interactions

Corradi, V., Sejdiu, B. I., Mesa-Galloso, H., Abdizadeh, H., Noskov, S. Y., Marrink, S. J., & Tieleman, D. P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00451 · Cited by 459

Transient Receptor Potential Channels in the Vasculature

Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420