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Light-induced control of protein destruction by opto-PROTAC
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Opto-PROTAC adds a light-inducible switch on PROTAC, enabling optical control for targeted degradation of proteins of interest .
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Cited by
PROTACs: past, present and future
Li, K., & Crews, C. M. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00193d · Cited by 869
Advancing targeted protein degradation for cancer therapy
Dale, B., Cheng, M., Park, K.-S., Kaniskan, H. Ü., Xiong, Y., & Jin, J. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00365-x · Cited by 632
Self-citationPROTACs: An Emerging Therapeutic Modality in Precision Medicine
Nalawansha, D. A., & Crews, C. M. (2020) · Cell Chemical Biology · doi:10.1016/j.chembiol.2020.07.020 · Cited by 490
Current strategies for the design of PROTAC linkers: a critical review
Troup, R. I., Fallan, C., & Baud, M. G. J. (2020) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2020.00018 · Cited by 424
“An example of this is the 4,5-dimethoxy-2-nitrobenzyl (DMNB) group, and “opto-PROTACs” have been reported with DMNB installed on the glutarimide NH of pomalidomide (10) [96], and the hydroxyl group of the VHL ligand (8) [97].”
BackgroundTargeted protein degradation: advances in drug discovery and clinical practice
Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326
Metadata
- Authors
- Liu, J., Chen, H., Ma, L., He, Z., Wang, D., Liu, Y., Lin, Q., Zhang, T., Gray, N., Kaniskan, H. Ü., Jin, J., & Wei, W.
- Venue
- Science Advances
- Published
- 2020-02-21
- Volume
- 6
- Issue
- 8
- Pages
- eaay5154-eaay5154
- ISSN
- 2375-2548 (ISSN-L)
- OpenAlex
- W3008203358
- Cited by
- 292
- References
- 49
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- gold
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