The origin of domestication genes in goats
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Abstract
Goat domestication selection mainly focused on immune and neural genes and involved both standing and introgressed variation.
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The genetics of domestication are relatively well understood for livestock.
“However, domestication is a long and difficult process, but the genetics of domestication are relatively well understood for livestock143–148.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [147]
The Introduction (page unavailable) says studies had identified candidate genes under selection in goats, and the Discussion reports evidence for the genetic basis of selected goat traits. But the Introduction also says the early evolutionary dynamics of key genes remain unclear; findings about goats do not establish that domestication genetics are relatively well understood across livestock. (LLM, conf=0.83)
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- Authors
- Zheng, Z., Wang, X., Li, M., Li, Y., Yang, Z., Wang, X., Pan, X., Gong, M., Zhang, Y., Guo, Y., Wang, Y., Liu, J., Cai, Y., Chen, Q., Okpeku, M., Colli, L., Cai, D., Wang, K., Huang, S., Sonstegard, T. S., Esmailizadeh, A., Zhang, W., Zhang, T., Xu, Y., Xu, N., Yang, Y., Han, J., Chen, L., Lesur, J., Daly, K. G., Bradley, D. G., Heller, R., Zhang, G., Wang, W., Chen, Y., & Jiang, Y.
- Affiliations
- Northwest A&F University (CN)
- Kunming Institute of Zoology (CN)
- Università Cattolica del Sacro Cuore (IT)
- Jilin University (CN)
- Northwestern Polytechnical University (CN)
- Recombinetics (United States) (US)
- Shahid Bahonar University of Kerman (IR)
- Inner Mongolia Agricultural University (CN)
- Zhejiang University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Centre National de la Recherche Scientifique (FR)
- Trinity College Dublin (IE)
- University of Copenhagen (DK)
- Corresponding author
- Chen, Yulin
- Jiang, Yu
- ORCID
- Zheng, Zhuqing
- Wang, Xihong
- Li, Ming
- Yang, Zhirui
- Wang, Xiaolong
- Pan, Xiangyu
- Gong, Mian
- Zhang, Yu
- Guo, Yingwei
- Wang, Yu
- Liu, Jing
- Cai, Yudong
- Chen, Qiuming
- Okpeku, Moses
- Colli, Licia
- Cai, Dawei
- Wang, Kun
- Huang, Shisheng
- Sonstegard, Tad S.
- Esmailizadeh, Ali
- Zhang, Wenguang
- Zhang, Tingting
- Xu, Yangbin
- Xu, Naiyi
- Yang, Yi
- Han, Jianlin
- Chen, Lei
- Lesur, Joséphine
- Daly, Kevin G.
- Bradley, Daniel G.
- Heller, Rasmus
- Zhang, Guojie
- Wang, Wen
- Chen, Yulin
- Jiang, Yu
- Venue
- Science Advances
- Published
- 2020-05-22
- Volume
- 6
- Issue
- 21
- Pages
- eaaz5216-eaaz5216
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7314551
- OpenAlex
- W3027192977
- Cited by
- 184
- References
- 126
- Citations by year
- 2026: 20 · 2025: 34 · 2024: 35 · 2023: 35 · 2022: 34 · 2021: 20 · 2020: 6
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by-nc)
- HAL (submittedVersion)
- CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research) (submittedVersion, cc-by-nc)
- Funders
- National Natural Science Foundation of China (31822052, 31572381, 31572369)
- Strategic Priority Research Program of CAS (XDB13000000)
- Talents Team Construction Fund of Northwestern Polytechnical University
- Tang scholar at Northwest A&F University
- The Chinese Government contribution to CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources in Beijing (2018-GJHZ-01)
- DFF Sapere Aude grant
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- goat domestication, domestication genes, MUC5B, mucin, enteric pathogens, immune resistance, introgression, positive selection, behavior
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