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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Human DNA Repair Genes

Wood, Richard D., Mitchell, Michael, Sgouros, John, Lindahl, Tomas·2001·Science
DOI 10.1126/science.1056154
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Abstract

Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.

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Research works printed but not linked: 22

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Metadata

Authors
Wood, R. D., Mitchell, M., Sgouros, J., & Lindahl, T.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2001-02-16
Volume
291
Issue
5507
Pages
1284-1289
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1056154
OpenAlex
W2012071848
Cited by
1,466
References
2
FWCI
23.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Human DNA Repair Genes. https://app.cochat.ai/papers/10.1126/science.1056154
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Wood, R. D., Mitchell, M., Sgouros, J., & Lindahl, T. (2001). Human DNA Repair Genes. Science. https://doi.org/10.1126/science.1056154

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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