Cited by 456Neuroscience and Neuropharmacology ResearchNerve injury and regenerationMemory and Neural Mechanisms

Postsynaptic induction of BDNF-mediated long-term potentiation

Kovalchuk, Yury, Hanse, Eric, Kafitz, Karl W., Konnerth, Arthur·2002·Science

Abstract

Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically involved in long-term potentiation (LTP). Previous reports point to a presynaptic site of neurotrophin action. By imaging dentate granule cells in mouse hippocampal slices, we identified BDNF-evoked Ca 2+ transients in dendrites and spines, but not at presynaptic sites. Pairing a weak burst of synaptic stimulation with a brief dendritic BDNF application caused an immediate and robust induction of LTP. LTP induction required activation of postsynaptic Ca 2+ channels and N -methyl- d -aspartate receptors and was prevented by the blockage of postsynaptic Ca 2+ transients. Thus, our results suggest that BDNF-mediated LTP is induced postsynaptically. Our finding that dendritic spines are the exclusive synaptic sites for rapid BDNF-evoked Ca 2+ signaling supports this conclusion.

Integrity signals

Registry

Crossref · 10.1126/science.1067766

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In the dentate gyrus subregion of the hippocampus, BDNF can facilitate LTP through postsynaptic mechanisms.

    “In the dentate gyrus (DG) subregion of the hippocampus, BDNF can facilitate LTP though postsynaptic mechanisms (Kovalchuk et al., 2002).”

    From BDNF - a key transducer of antidepressant effects (2016) · cites this paper as Kovalchuk et al., 2002

  • Activation of NMDA receptors can impact BDNF expression resulting in enhanced LTP.

    “It is well documented that activation of NMDA receptors can impact BDNF expression resulting in enhanced LTP (Kovalchuk et al., 2002).”

    From BDNF - a key transducer of antidepressant effects (2016) · cites this paper as Kovalchuk et al., 2002

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kovalchuk, Y., Hanse, E., Kafitz, K. W., & Konnerth, A.
Affiliations
Physiologisches Institut (DE)
Corresponding author
  • Hanse, Eric
  • Konnerth, Arthur
Venue
Science
Published
2002-03
Volume
295
Issue
5560
Pages
1729-1734
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2005254595
Cited by
456
References
3
Citations by year
2026: 3 · 2025: 9 · 2024: 12 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 20 · 2019: 11 · 2018: 10 · 2017: 16 · 2016: 16 · 2015: 15 · 2014: 14 · 2013: 24 · 2012: 18
FWCI
15.10
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
brain-derived neurotrophic factor, long-term potentiation, postsynaptic signaling, dendritic calcium transients, dendritic spines, NMDA receptor, calcium channels, neurotrophins, dentate gyrus granule cells, hippocampus, synaptic plasticity
MeSH terms
Action Potentials, Animals, Axons, Calcium, Dendrites, Mice, Inbred BALB C, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Patch-Clamp Techniques, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Perforant Pathway, Excitatory Postsynaptic Potentials, Calcium Signaling, Receptor, trkB, Mice, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review