Postsynaptic induction of BDNF-mediated long-term potentiation
Abstract
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically involved in long-term potentiation (LTP). Previous reports point to a presynaptic site of neurotrophin action. By imaging dentate granule cells in mouse hippocampal slices, we identified BDNF-evoked Ca 2+ transients in dendrites and spines, but not at presynaptic sites. Pairing a weak burst of synaptic stimulation with a brief dendritic BDNF application caused an immediate and robust induction of LTP. LTP induction required activation of postsynaptic Ca 2+ channels and N -methyl- d -aspartate receptors and was prevented by the blockage of postsynaptic Ca 2+ transients. Thus, our results suggest that BDNF-mediated LTP is induced postsynaptically. Our finding that dendritic spines are the exclusive synaptic sites for rapid BDNF-evoked Ca 2+ signaling supports this conclusion.
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In the dentate gyrus subregion of the hippocampus, BDNF can facilitate LTP through postsynaptic mechanisms.
“In the dentate gyrus (DG) subregion of the hippocampus, BDNF can facilitate LTP though postsynaptic mechanisms (Kovalchuk et al., 2002).”
From BDNF - a key transducer of antidepressant effects (2016) · cites this paper as Kovalchuk et al., 2002
Activation of NMDA receptors can impact BDNF expression resulting in enhanced LTP.
“It is well documented that activation of NMDA receptors can impact BDNF expression resulting in enhanced LTP (Kovalchuk et al., 2002).”
From BDNF - a key transducer of antidepressant effects (2016) · cites this paper as Kovalchuk et al., 2002
Cites
Tanaka, T., Saito, H., & Matsuki, N. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-09-02959.1997 · Cited by 385 · see citing works
Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V, Thoenen, H., & Bonhoeffer, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12547 · Cited by 351 · see citing works
Messaoudi, E., Bårdsen, K., Srebro, B., & Bramham, C. R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.496 · Cited by 208 · see citing works
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Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works
The yin and yang of neurotrophin action
Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356 · see citing works
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works
BDNF - a key transducer of antidepressant effects
Björkholm, C., & Monteggia, L. M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.034 · Cited by 958 · see citing works
“BDNF infusion into the hippocampus may also induce LTP in vivo (Ying et al., 2002), confirming the physiological relevance of this finding.”
BackgroundInfluentialBDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
Yoshii, A., & Constantine‐Paton, M. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20765 · Cited by 744 · see citing works
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Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works
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Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00279-0 · Cited by 606 · see citing works
The selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489 · see citing works
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425 · see citing works
Yoshii, A., & Constantine-Paton, M. (2007) · Nature Neuroscience · doi:10.1038/nn1903 · Cited by 345 · see citing works
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Harward, S. C., Hedrick, N. G., Hall, C. E., Parra-Bueno, P., Milner, T. A., Pan, E., Laviv, T., Hempstead, B. L., Yasuda, R., & McNamara, J. O. (2016) · Nature · doi:10.1038/nature19766 · Cited by 325 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
Role of the brain‐derived neurotrophic factor at glutamatergic synapses
Carvalho, A. L., Caldeira, M. V., Santos, S. D., & Duarte, C. B. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707509 · Cited by 290 · see citing works
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Blum, R., Kafitz, K. W., & Konnerth, A. (2002) · Nature · doi:10.1038/nature01085 · Cited by 266 · see citing works
Self-citationJiang, X., Xu, K., Hoberman, J., Tian, F., Marko, A. J., Waheed, J. F., Harris, C. R., Marini, A. M., Enoch, M.-A., & Lipsky, R. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300703 · Cited by 244 · see citing works
Form follows function: BDNF and its involvement in sculpting the function and structure of synapses
Zagrebelsky, M., & Korte, M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.029 · Cited by 241 · see citing works
LTP consolidation: Substrates, explanatory power, and functional significance
Lynch, G., Rex, C. S., & Gall, C. M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.027 · Cited by 214 · see citing works
Obesity and vulnerability of the CNS
Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.004 · Cited by 200 · see citing works
Laske, C., Banschbach, S., Stransky, E., Bosch, S., Straten, G., Machann, J., Fritsche, A., Hipp, A., Niess, A., & Eschweiler, G. W. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991234 · Cited by 171 · see citing works
Signaling mechanisms underlying dendrite formation
Miller, F. D., & Kaplan, D. R. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00072-2 · Cited by 160 · see citing works
BDNF signaling during the lifetime of dendritic spines
Zagrebelsky, M., Tacke, C., & Korte, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03226-5 · Cited by 147 · see citing works
Kawai, H., Zago, W., & Berg, D. K. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07903.2002 · Cited by 140 · see citing works
Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137 · see citing works
Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging
Rapoport, J. L., & Gogtay, N. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301553 · Cited by 132 · see citing works
High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons
Andreska, T., Aufmkolk, S., Sauer, M., & Blum, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00107 · Cited by 100 · see citing works
Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.
Christie, B. R., Eadie, B. D., Kannangara, T. S., Robillard, J. M., Shin, J., & Titterness, A. K. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8033-2 · Cited by 99 · see citing works
Microglial modulation of neuronal activity in the healthy brain
York, E. M., Bernier, L., & MacVicar, B. A. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22571 · Cited by 98 · see citing works
Kwon, D.-H., Kim, B.-S., Chang, H., Kim, Y.-I., Jo, S. A., & Leem, Y.-H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.111 · Cited by 69 · see citing works
Pharmacological enhancement of memory or cognition in normal subjects
Lynch, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00090 · Cited by 46 · see citing works
Dufor, T., Lohof, A. M., & Sherrard, R. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216456 · Cited by 28 · see citing works
- Authors
- Kovalchuk, Y., Hanse, E., Kafitz, K. W., & Konnerth, A.
- Affiliations
- Physiologisches Institut (DE)
- Corresponding author
- Hanse, Eric
- Konnerth, Arthur
- Venue
- Science
- Published
- 2002-03
- Volume
- 295
- Issue
- 5560
- Pages
- 1729-1734
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005254595
- Cited by
- 456
- References
- 3
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 12 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 20 · 2019: 11 · 2018: 10 · 2017: 16 · 2016: 16 · 2015: 15 · 2014: 14 · 2013: 24 · 2012: 18
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- brain-derived neurotrophic factor, long-term potentiation, postsynaptic signaling, dendritic calcium transients, dendritic spines, NMDA receptor, calcium channels, neurotrophins, dentate gyrus granule cells, hippocampus, synaptic plasticity
- MeSH terms
- Action Potentials, Animals, Axons, Calcium, Dendrites, Mice, Inbred BALB C, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Patch-Clamp Techniques, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Perforant Pathway, Excitatory Postsynaptic Potentials, Calcium Signaling, Receptor, trkB, Mice, In Vitro Techniques
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