Cited by 69Stress Responses and CortisolExercise and Physiological ResponsesNerve injury and regeneration

Exercise ameliorates cognition impairment due to restraint stress-induced oxidative insult and reduced BDNF level

Kwon, Dong-Ho, Kim, Bum-Soo, Chang, Hyukki, Kim, Young-In, Jo, Sangmee Ahn, Leem, Yea-Hyun·2013·Biochemical and Biophysical Research Communications

Abstract

We assessed whether chronic treadmill exercise attenuated restraint stress-induced cognition impairment. Although serum corticosterone was not significantly altered by exercise, the restraint-induced increases in hippocampal malondialdehyde (MDA) and 4-hydroxynonenal (HNE) were reduced by chronic exercise. The exercise paradigm also reversed stress-induced reductions in brain-derived neurotrophic factor (BDNF), which increased cAMP response element-binding protein (CREB) and AKT activation. We verified the relationship between oxidative stress and BDNF signaling by treating primary hippocampal cultures with hydrogen peroxide (H2O2), which reduced BDNF and phosphorylated CREB and AKT (p-CREB, p-AKT) in a dose-dependent manner. Notably, pretreatment with N-acetylcysteine (NAC) reversed these decreases in a dose-dependent manner. These findings suggest that chronic exercise can ameliorate repeated stress-induced cognitive impairment by detoxifying reactive oxygen species (ROS) in the hippocampus and activating BDNF signaling.

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Crossref · 10.1016/j.bbrc.2013.02.111

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  • In hippocampal cell cultures taken from rodents treated with hydrogen peroxide, there is an inverse relationship between BDNF expression levels and hydrogen peroxide concentration.

    “In fact, when treated with hydrogen peroxide, a potent ROS, hippocampal cell cultures taken from rodents showed an inverse relationship between BDNF expression levels and hydrogen peroxide concentration (Kwon et al., 2013).”

    From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Kwon et al., 2013

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Authors
Kwon, D.-H., Kim, B.-S., Chang, H., Kim, Y.-I., Jo, S. A., & Leem, Y.-H.
Affiliations
  • Sungshin Women's University (KR)
  • Seoul Women's University (KR)
  • Dankook University (KR)
Corresponding author
  • Jo, Sangmee Ahn
  • Leem, Yea-Hyun
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2013-05
Volume
434
Issue
2
Pages
245-251
ISSN
0006-291X (ISSN-L)
OpenAlex
W2034424531
Cited by
69
References
33
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 20 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 2
FWCI
3.34
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Korean Health Technology R&D Project (A120004)
  • Ministry of Health & Welfare, Republic of Korea
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
restraint stress, cognitive impairment, oxidative stress, hippocampus, brain-derived neurotrophic factor, CREB, Akt signaling, malondialdehyde, 4-hydroxynonenal, reactive oxygen species, N-acetylcysteine, hydrogen peroxide, corticosterone
MeSH terms
Acetylcysteine, Aldehydes, Animals, Cognition, Cognition Disorders, Corticosterone, Dose-Response Relationship, Drug, Exercise Test, Hippocampus, Hydrogen Peroxide, Immunohistochemistry, Male, Malondialdehyde, Mice, Inbred C57BL, Phosphorylation, Physical Conditioning, Animal, Restraint, Physical, Stress, Psychological, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Maze Learning, Brain-Derived Neurotrophic Factor, Mice, Primary Cell Culture

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