Exercise ameliorates cognition impairment due to restraint stress-induced oxidative insult and reduced BDNF level
Abstract
We assessed whether chronic treadmill exercise attenuated restraint stress-induced cognition impairment. Although serum corticosterone was not significantly altered by exercise, the restraint-induced increases in hippocampal malondialdehyde (MDA) and 4-hydroxynonenal (HNE) were reduced by chronic exercise. The exercise paradigm also reversed stress-induced reductions in brain-derived neurotrophic factor (BDNF), which increased cAMP response element-binding protein (CREB) and AKT activation. We verified the relationship between oxidative stress and BDNF signaling by treating primary hippocampal cultures with hydrogen peroxide (H2O2), which reduced BDNF and phosphorylated CREB and AKT (p-CREB, p-AKT) in a dose-dependent manner. Notably, pretreatment with N-acetylcysteine (NAC) reversed these decreases in a dose-dependent manner. These findings suggest that chronic exercise can ameliorate repeated stress-induced cognitive impairment by detoxifying reactive oxygen species (ROS) in the hippocampus and activating BDNF signaling.
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In hippocampal cell cultures taken from rodents treated with hydrogen peroxide, there is an inverse relationship between BDNF expression levels and hydrogen peroxide concentration.
“In fact, when treated with hydrogen peroxide, a potent ROS, hippocampal cell cultures taken from rodents showed an inverse relationship between BDNF expression levels and hydrogen peroxide concentration (Kwon et al., 2013).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Kwon et al., 2013
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- Authors
- Kwon, D.-H., Kim, B.-S., Chang, H., Kim, Y.-I., Jo, S. A., & Leem, Y.-H.
- Affiliations
- Sungshin Women's University (KR)
- Seoul Women's University (KR)
- Dankook University (KR)
- Corresponding author
- Jo, Sangmee Ahn
- Leem, Yea-Hyun
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 434
- Issue
- 2
- Pages
- 245-251
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2034424531
- Cited by
- 69
- References
- 33
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 20 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 2
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korean Health Technology R&D Project (A120004)
- Ministry of Health & Welfare, Republic of Korea
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- restraint stress, cognitive impairment, oxidative stress, hippocampus, brain-derived neurotrophic factor, CREB, Akt signaling, malondialdehyde, 4-hydroxynonenal, reactive oxygen species, N-acetylcysteine, hydrogen peroxide, corticosterone
- MeSH terms
- Acetylcysteine, Aldehydes, Animals, Cognition, Cognition Disorders, Corticosterone, Dose-Response Relationship, Drug, Exercise Test, Hippocampus, Hydrogen Peroxide, Immunohistochemistry, Male, Malondialdehyde, Mice, Inbred C57BL, Phosphorylation, Physical Conditioning, Animal, Restraint, Physical, Stress, Psychological, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Maze Learning, Brain-Derived Neurotrophic Factor, Mice, Primary Cell Culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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