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Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase
Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123 + DCs. IDO + DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
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Metadata
- Authors
- Munn, D. H., Sharma, M. D., Lee, J. R., Jhaver, K. G., Johnson, T. S., Keskin, D. B., Marshall, B., Chandler, P., Antonia, S. J., Burgess, R., Slingluff, C. L., & Mellor, A. L.
- Venue
- Science
- Published
- 2002-09-13
- Volume
- 297
- Issue
- 5588
- Pages
- 1867-1870
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2119939110
- Cited by
- 1,028
- References
- 0
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- closed
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