Role of dietary protein and muscular fitness on longevity and aging
Open accessAbstract
Muscle atrophy is an unfortunate effect of aging and many diseases and can compromise physical function and impair vital metabolic processes. Low levels of muscular fitness together with insufficient dietary intake are major risk factors for illness and mortality from all causes. Ultimately, muscle wasting contributes significantly to weakness, disability, increased hospitalization, immobility, and loss of independence. However, the extent of muscle wasting differs greatly between individuals due to differences in the aging process per se as well as physical activity levels. Interventions for sarcopenia include exercise and nutrition because both have a positive impact on protein anabolism but also enhance other aspects that contribute to well-being in sarcopenic older adults, such as physical function, quality of life, and anti-inflammatory state. The process of aging is accompanied by chronic immune activation, and sarcopenia may represent a consequence of a counter-regulatory strategy of the immune system. Thereby, the kynurenine pathway is induced, and elevation in the ratio of kynurenine to tryptophan concentrations, which estimates the tryptophan breakdown rate, is often linked with inflammatory conditions and neuropsychiatric symptoms. A combined exercise program consisting of both resistance-type and endurance-type exercise may best help to ameliorate the loss of skeletal muscle mass and function, to prevent muscle aging comorbidities, and to improve physical performance and quality of life. In addition, the use of dietary protein supplementation can further augment protein anabolism but can also contribute to a more active lifestyle, thereby supporting well-being and active aging in the older population.
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Dietary protein supplementation can enhance cellular protein synthesis and metabolism.
“Dietary protein supplementation can also enhance cellular protein synthesis and metabolism [74].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [74]
Ingesting sufficient protein can help healing pressure ulcers in rats, while both excess and inadequate protein intake are detrimental to ulcer healing.
“Studies have shown that ingesting sufficient protein can help in healing pressure ulcers in rats, while both excess and inadequate protein intake are detrimental to ulcer healing.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [74]
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Bioactive Compounds for Skin Health: A Review
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Never Too Old for Cardiac Rehabilitation
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Nutrition for Older Athletes: Focus on Sex-Differences
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2021 AAHA Working, Assistance, and Therapy Dog Guidelines
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Role of Nutritional Elements in Skin Homeostasis: A Review
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Review: myogenic and muscle toxicity targets of environmental methylmercury exposure
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Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice
Navarro, C. D. C., Francisco, A., Costa, E. F. D., Costa, A. P. D., Sartori, M. R., Bizerra, P. F. V., Salgado, A. R., Figueira, T. R., Vercesi, A. E., & Castilho, R. F. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112465 · Cited by 8 · see citing works
Tursi, F., Nobile, V., Cestone, E., Ponti, I. D., Lepoudère, A., Sergheraert, R., & Soulard, J. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16626 · Cited by 8 · see citing works
Stanfield, B., Kaeberlein, M. R., Leroux, B. G., Jones, J. P., Lucas, R., & Arroll, B. (2024) · Trials · doi:10.1186/s13063-024-08490-2 · Cited by 7 · see citing works
Nardon, M., Venturelli, M., Ruzzante, F., Longo, V. D., & Bertucco, M. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04867-2 · Cited by 6 · see citing works
Strasser, B., Kohlboeck, G., Hermanky, M., & Leitzmann, M. F. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01461-7 · Cited by 6 · see citing works
Stanfield, B., Leroux, B., Kaeberlein, M. R., Jones, J., & Lucas, R. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70274 · Cited by 5 · see citing works
Importance of Assessing Muscular Fitness in Secondary Care
Strasser, B. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.583810 · Cited by 5 · see citing works
Sarcopenia em Idosos: Um estudo de revisão
Yanaga, M. C. (2020) · International Journal of Nutrology · doi:10.1055/s-0040-1718991 · Cited by 5 · see citing works
Plant-Based Nutrition and Supplements for Optimal Athletic Performance
Rosenfeld, R. M., Zinman, S., & Bonnet, J. P. (2025) · American Journal of Lifestyle Medicine · doi:10.1177/15598276251393663 · Cited by 4 · see citing works
A relação da reeducação alimentar e atividade física na terceira idade
Siqueira, H. B. B., Garcia, R. C., Freitas, F. M. N. D. O., & Ferreira, J. C. D. S. (2022) · Research Society and Development · doi:10.33448/rsd-v11i15.37131 · Cited by 2 · see citing works
Tachibana, N., Fukao, M., Tomoko, I. R. I. E., IRISAWA, Y., Shirono, H., Oarada, M., Nikawa, T., & Fukaya, T. (2020) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.66.449 · Cited by 2 · see citing works
„Role of Dietary Protein and Muscular Fitness on Longevity and Aging“
Tramontana, A., & Strasser, B. (2018) · Journal für Gynäkologische Endokrinologie/Schweiz · doi:10.1007/s41975-018-0032-6 · Cited by 1 · see citing works
Bakinde, S. T., Olaitan, O. L., & Dominic, O. L. (2023) · Indonesian Journal Of Educational Research and Review · doi:10.23887/ijerr.v6i1.60139 · Cited by 3 · see citing works
Martín-Cuesta, J., Calatayud, J., Casaña, J., Smith, L., Pardhan, S., Sánchez, G. F. L., Suso‐Martí, L., Cuenca‐Martínez, F., & López‐Bueno, R. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02577-7 · Cited by 1 · see citing works
Extrinsic risk factors for skin aging
Taghupia, I. V., Setyaningrum, T., & Rejeki, P. S. (2024) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2024.24.3.3995 · Cited by 1 · see citing works
Athletes’ Sensory Evaluation and Willingness to Pay for High-Protein Bread
Selvaggi, R., Reitano, M., Arena, E., Grasso, A., Pecorino, B., & Pappalardo, G. (2025) · Foods · doi:10.3390/foods14152673 · Cited by 1 · see citing works
„Role of Dietary Protein and Muscular Fitness on Longevity and Aging“
Tramontana, A., & Strasser, B. (2018) · Journal für Gynäkologische Endokrinologie/Österreich · doi:10.1007/s41974-018-0031-2
Disadaptive Disorders of Regulation of Functions with Aging
Artemenkov, A. A. (2019) · Advances in Gerontology · doi:10.1134/s2079057019020024
The impact on high-fat diet on skeletal muscle stem cell recruitment in CD36 deficient mice
Verpoorten, S. (2019) · Repository@Hull (Worktribe) (University of Hull)
Васильевна, М. Г., Шиловский, Г. А., & Khokhlov, A. N. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521100092
Dutra, A. D. S., Muniz, G. A. S., Brito, A. C. D., Fontenele, A. M. M., & da Conceição, S. I. O. (2021) · DEMETRA Alimentação Nutrição & Saúde · doi:10.12957/demetra.2021.59857
Nutrition and Aging: Nutrition Balance and Dietary Protein Needs
Strasser, B. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_130
Nutrition and Aging: Nutrition Balance and Dietary Protein Needs
Strasser, B. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_130-1
Li, X., Xu, J., Zhu, L., Yang, S.-J., Yu, L., Lv, W., & Hu, J. (2020) · doi:10.21203/rs.3.rs-87555/v1
Costa, I. R., Costa, J. P. R., Costa, M. D. S., Macedo, A., Lisboa, G. B., Fadel, M. F. F., Silva, N. H. V. E., & Abumussi, A. L. N. (2023) · International Journal of Nutrology · doi:10.54448/ijn23213
Bewegung und Gesundheit: Immunsystem im Fokus
Strasser, B., Weyh, C., & Krüger, K. (2024) · Springer eBooks · doi:10.1007/978-3-662-67508-3_4
Wu, X., Kong, S.-P., Wei, S., Ning, Y., Tang, Y., Wang, Y., Zheng, Y., Yu, X., Liu, C., Cui, H.-F., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4636408/v1
Ha, G., & Lee, K.-H. (2025) · Exercise Science · doi:10.15857/ksep.2025.00038
Sarcopenia in elderly patients: an integrative literature review
da Costa, M. M., Scremin, M., Rosa, R. C., Vaichulonis, C. G., Reginato, B. C., Lima, D. D.-D., & Soares, A. V. (2025) · Caderno Pedagógico · doi:10.54033/cadpedv22n7-317
Lo, C.-J., Lin, C.-M., Fan, C.-M., Tang, H.-Y., Liu, H.-F., Ho, H.-Y., & Cheng, M.-L. (2023) · Figshare · doi:10.6084/m9.figshare.24628114
Metabolic Tuning trifft Longevity an der Schnittstelle zur effizienten Prävention
Fux, V., Gröber, U., Rappl, P., & Schütz, B. (2026) · Zeitschrift für Orthomolekulare Medizin · doi:10.1055/a-2819-5011
When I use a word . . . Centenarians
Aronson, J. K. (2026) · BMJ · doi:10.1136/bmj.s902
Park, J. Y., & Park, H. (2026) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2026.112861
Periorbital Aging Protection and Prevention
Bagherani, N., Smoller, B. R., Bagherani, N., & Ghanadan, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-9678-2_3
Edukasi Pengurus Pondok Lansia Tulus Kasih tentang Abon Ekstrak Ikan Lele untuk Nutrisi Paliatif
Sihombing, F., Raniadita, M. A., Wityadarda, C., & Rumaseuw, E. S. (2026) · Jurnal Masyarakat Madani Indonesia · doi:10.59025/7h923872
- Authors
- Strasser, B., Volaklis, K., Fuchs, D., & Burtscher, M.
- Affiliations
- Innsbruck Medical University (AT)
- Technical University of Munich (DE)
- Corresponding author
- Strasser, Barbara
- Venue
- Aging and Disease
- Publisher
- Aging and Disease
- Published
- 2018
- Volume
- 9
- Issue
- 1
- Pages
- 119
- ISSN
- 2152-5250 (ISSN-L)
- PMC
- PMC5772850
- OpenAlex
- W2784598358
- Cited by
- 78
- References
- 144
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 14 · 2020: 13 · 2019: 12 · 2018: 6
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Aging and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, muscle atrophy, dietary protein, muscular fitness, longevity, aging, protein anabolism, resistance training, endurance exercise, kynurenine pathway, chronic immune activation, inflammation, physical function, active ageing, older adults, protein supplementation
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