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Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis
Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
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Metadata
- Authors
- Paulsen, I. T., Banerjei, L., Myers, G. S. A., Nelson, K. E., Seshadri, R., Read, T. D., Fouts, D. E., Eisen, J. A., Gill, S. R., Heidelberg, J. F., Tettelin, H., Dodson, R. J., Umayam, L., Brinkac, L., Beanan, M., Daugherty, S., DeBoy, R. T., Durkin, S., Kolonay, J., Madupu, R., Nelson, W., Vamathevan, J., Tran, B., Upton, J., Hansen, T., Shetty, J., Khouri, H., Utterback, T., Radune, D., Ketchum, K. A., Dougherty, B. A., & Fraser, C. M.
- Venue
- Science
- Published
- 2003-03-28
- Volume
- 299
- Issue
- 5615
- Pages
- 2071-2074
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151742889
- Cited by
- 930
- References
- 0
- FWCI
- 27.55
- Type
- journal article
- Language
- en
- Open access
- closed
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