The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial Segment
Abstract
The sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Na v 1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Na v 1.2II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, this motif may play a fundamental role in controlling electrical excitability during development and plasticity.
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Cites
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Polarized Domains of Myelinated Axons
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Information processing in the axon
Debanne, D. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1397 · Cited by 400
Self-citationAnkyrinG is required for maintenance of the axon initial segment and neuronal polarity
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A cardiac arrhythmia syndrome caused by loss of ankyrin-B function
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Stevens, S. R., Longley, C. M., Ogawa, Y., Teliska, L. H., Arumanayagam, A. S., Nair, S., Oses-Prieto, J. A., Burlingame, A. L., Cykowski, M. D., Xue, M., et al. (2021) · eLife · doi:10.7554/elife.66491 · Cited by 53
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Sun, W., Wagnon, J. L., Mahaffey, C. L., Briese, M., Ule, J., & Frankel, W. N. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240168 · Cited by 36
Ankyrin-B Regulates Cav2.1 and Cav2.2 Channel Expression and Targeting
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Metadata
- Authors
- Garrido, J. J., Giraud, P., Carlier, E., Fernandes, F., Moussif, A., Fache, M.-P., Debanne, D., & Dargent, B.
- Venue
- Science
- Published
- 2003-06-27
- Volume
- 300
- Issue
- 5628
- Pages
- 2091-2094
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070691915
- Cited by
- 356
- References
- 28
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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