The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin
Abstract
Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.
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“In activated CD8 T cells, these TFs regulate the production of cytokines and lytic proteins, such as tumor necrosis factor (TNF), IFNγ, granzyme B (GzmB), and perforin (48).”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [48]
In the citing paper
“The cytotoxic subset appeared to be dominantly regulated by TFs associated with cytotoxicity and T helper 1 (TH1) polarization, including Eomes, Runx2, Runx3, and Tbx21 regulons [Fig. 5B; (42, 48)].”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [48]
Citations
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Transforming Growth Factor-β Signaling in Immunity and Cancer
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Metadata
- Authors
- Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., & Reiner, S. L.
- Affiliations
- Mount Sinai Hospital (CA)
- Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- Corresponding author
- Reiner, Steven L.
- ORCID
- Venue
- Science
- Published
- 2003-11-07
- Volume
- 302
- Issue
- 5647
- Pages
- 1041-1043
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2119319172
- Cited by
- 1,014
- References
- 18
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 32 · 2023: 47 · 2022: 45 · 2021: 72 · 2020: 60 · 2019: 49 · 2018: 63 · 2017: 33 · 2016: 50 · 2015: 45 · 2014: 56 · 2013: 69 · 2012: 56
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007229, GM-07229)
- National Institute of Allergy and Infectious Diseases (AI 042370, R01AI042370)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- Eomesodermin, CD8+ T cells, effector T cell differentiation, transcription factors, T-bet, interferon-gamma, perforin, granzyme B, cell-mediated immunity, transcriptional regulation
- MeSH terms
- T-bet Transcription Factor, Amino Acid Sequence, Animals, Arenaviridae Infections, Base Sequence, Cell Differentiation, Cytotoxicity, Immunologic, Gene Expression Regulation, Interferon-gamma, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Transcription Factors, CD8-Positive T-Lymphocytes, Th2 Cells, T-Box Domain Proteins, Mice, Pore Forming Cytotoxic Proteins, Granzymes, Perforin
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