Cited by 1,014T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, Erika L., Mullen, Alan C., Martins, Gislâine A., Krawczyk, Connie M., Hutchins, Anne S., Zediak, Valerie P., Banica, Monica, DiCioccio, Catherine B., Gross, Darrick A., Mao, Chai-an, Shen, Hao, Cereb, Nezih, Yang, Soo Y., Lindsten, Tullia, Rossant, Janet, Hunter, Christopher A., Reiner, Steven L.·2003·Science

DOI 10.1126/science.1090148

Open this paper in CoChat — free account

Abstract

Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.

Integrity signals

Registry

Crossref · 10.1126/science.1090148

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory
Shedlock, D. J., & Shen, H. (2003) · Science · doi:10.1126/science.1082305 · Cited by 1,450
Self-citation
Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., & Glimcher, L. H. (2002) · Science · doi:10.1126/science.1065543 · Cited by 1,172
Molecular and functional profiling of memory CD8 T cell differentiation.
Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019

Flagged first, then by citations

Show all 18 references

Sorted by citations

Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
Fehrenbacher, L., Spira, A., Ballinger, M., Kowanetz, M., Vansteenkiste, J., Mazieres, J., Park, K., Smith, D., Artal-Cortes, A., Lewanski, C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00587-0 · Cited by 2,756
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
McLane, L. M., Abdel-Hakeem, M. S., & Wherry, E. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055318 · Cited by 2,054
CD4 T cells: fates, functions, and faults
Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,911
Single-cell chromatin state analysis with Signac
Stuart, T., Srivastava, A., Madad, S., Lareau, C. A., & Satija, R. (2021) · Nature Methods · doi:10.1038/s41592-021-01282-5 · Cited by 1,769
Regulation of Interferon‐γ During Innate and Adaptive Immune Responses
Schoenborn, J. R., & Wilson, C. B. (2007) · Advances in immunology · doi:10.1016/s0065-2776(07)96002-2 · Cited by 1,709
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
Self-citation
Roles of IFN-γ in tumor progression and regression: A review
Jorgovanovic, D., Song, M., Wang, L., & Zhang, Y. (2020) · Biomarker Research · doi:10.1186/s40364-020-00228-x · Cited by 1,234
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Beltra, J., Manne, S., Abdel-Hakeem, M. S., Kurachi, M., Giles, J. R., Chen, Z., Casella, V., Ngiow, S. F., Khan, O., Huang, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.014 · Cited by 1,139
Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages
Klose, C. S. N., Flach, M., Möhle, L., Rogell, L., Hoyler, T., Ebert, K., Fabiunke, C., Pfeifer, D., Sexl, V., Fonseca‐Pereira, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.030 · Cited by 1,081
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
Gattinoni, L., Zhong, X.-S., Palmer, D. C., Ji, Y., Hinrichs, C. S., Yu, Z., Wrzesinski, C., Boni, A., Cassard, L., Garvin, L. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1982 · Cited by 1,031
Tissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
Satpathy, A. T., Granja, J. M., Yost, K. E., Qi, Y., Meschi, F., McDermott, G. P., Olsen, B. N., Mumbach, M. R., Pierce, S. E., Corces, M. R., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0206-z · Cited by 980
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
Gattinoni, L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24480 · Cited by 947
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Szabo, P. A., Levitin, H. M., Miron, M., Snyder, M. E., Senda, T., Yuan, J., Cheng, Y. L., Bush, E. C., Dogra, P., Thapa, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12464-3 · Cited by 756
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
Cortés, A., Hadler, J., Robinson, P. C., Leo, P., Cremin, K., Pryce, K., Harris, J., Bradbury, L. A., Kenna, T., Yang, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2667 · Cited by 872
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer
Plitas, G., Konopacki, C., Wu, K., Bos, P. D., Morrow, M., Putintseva, E. V., Chudakov, D. M., & Rudensky, A. Y. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.032 · Cited by 695
The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation
Gordon, S. M., Chaix, J., Rupp, L. J., Wu, J., Madera, S., Sun, J. C.-Y., Lindsten, T., & Reiner, S. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.016 · Cited by 765
Self-citation
T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells
Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P., Biron, C. A., Gapin, L., & Glimcher, L. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00076-7 · Cited by 722
Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death
Chowdhury, D., & Lieberman, J. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090404 · Cited by 705
Inflammatory cytokines as a third signal for T cell activation
Curtsinger, J., & Mescher, M. F. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.02.013 · Cited by 618
The Roles of CD8+ T Cell Subsets in Antitumor Immunity
Paul, M. S., & Ohashi, P. S. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.06.003 · Cited by 635
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate
Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 625
Peripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors
Zhu, J., & Paul, W. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00951.x · Cited by 624
Interferon-γ: teammate or opponent in the tumour microenvironment?
Gocher, A. M., Workman, C. J., & Vignali, D. A. A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00566-3 · Cited by 612
Molecular regulation of effector and memory T cell differentiation
Chang, J. T., Wherry, E. J., & Goldrath, A. W. (2014) · Nature Immunology · doi:10.1038/ni.3031 · Cited by 604
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
Caushi, J. X., Zhang, J., Ji, Z., Vaghasia, A. M., Zhang, B., Hsiue, E. H.-C., Mog, B. J., Hou, W., Justesen, S. F. L., Blosser, R. L., et al. (2021) · Nature · doi:10.1038/s41586-021-03752-4 · Cited by 571
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
Zhou, X., Jeker, L. T., Fife, B. T., Zhu, S., Anderson, M. S., McManus, M. T., & Bluestone, J. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080707 · Cited by 520
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
Cruz‐Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y., & Rao, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081242 · Cited by 518
Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses
Kallies, A., Xin, A., Belz, G. T., & Nutt, S. L. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.021 · Cited by 511
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
Zhu, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.010 · Cited by 523
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
Singer, A., Adoro, S., & Park, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2416 · Cited by 497
T-bet: a bridge between innate and adaptive immunity
Lazarevic, V., Glimcher, L. H., & Lord, G. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3536 · Cited by 486
Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation
Mempel, T. R., Pittet, M. J., Khazaie, K., Weninger, W., Weissleder, R., von Boehmer, H., & von Andrian, U. H. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.015 · Cited by 501
Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor
Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480
Precursor exhausted T cells: key to successful immunotherapy?
Kallies, A., Zehn, D., & Utzschneider, D. T. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0223-7 · Cited by 483
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
Hinrichs, C. S., Spolski, R. J., Paulos, C. M., Gattinoni, L., Kerstann, K. W., Palmer, D. C., Klebanoff, C. A., Rosenberg, S. A., Leonard, W. J., & Restifo, N. P. (2008) · Blood · doi:10.1182/blood-2007-09-113050 · Cited by 465
T cell responses: naïve to memory and everything in between
Pennock, N. D., White, J. T., Cross, E. W., Cheney, E. E., Tamburini, B. A., & Kedl, R. M. (2013) · Advances in Physiology Education · doi:10.1152/advan.00066.2013 · Cited by 461
CD4 CTL, a cytotoxic subset of CD4(+) T cells, their differentiation and function
Takeuchi, A., & Saito, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00194 · Cited by 431
T-Box Genes in Vertebrate Development
Naiche, L. A., Harrelson, Z., Kelly, R. G., & Papaioannou, V. E. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.105925 · Cited by 437
Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche
Banerjee, A., Gordon, S. M., Intlekofer, A. M., Paley, M., Mooney, E. C., Lindsten, T., Wherry, E. J., & Reiner, S. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002042 · Cited by 429
Self-citation
The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells
Kurachi, M., Barnitz, R. A., Yosef, N., Odorizzi, P. M., DiIorio, M. A., Lemieux, M. E., Yates, K. B., Godec, J., Klatt, M. G., Regev, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2834 · Cited by 392
Anomalous Type 17 Response to Viral Infection by CD8 + T Cells Lacking T-bet and Eomesodermin
Intlekofer, A. M., Banerjee, A., Takemoto, N., Gordon, S. M., DeJong, C. S., Shin, H., Hunter, C. A., Wherry, E. J., Lindsten, T., & Reiner, S. L. (2008) · Science · doi:10.1126/science.1159806 · Cited by 409
Self-citation
Overcoming TGFβ-mediated immune evasion in cancer
Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377
The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain
Wakim, L. M., Davis, A. S. W., Liu, R., Hu, Y., Villadangos, J. A., Smyth, G. K., & Bevan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201305 · Cited by 381
MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells
Steiner, D. F., Thomas, M. F., Hu, J. K., Yang, Z., Babiarz, J., Allen, C. D. C., Matloubian, M., Blelloch, R. H., & Ansel, K. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.009 · Cited by 365
Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells
Cham, C. M., & Gajewski, T. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4670 · Cited by 359
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes
Elyahu, Y., Hekselman, I., Eizenberg-Magar, I., Berner, O., Strominger, I., Schiller, M., Mittal, K., Nemirovsky, A., Eremenko, E., Vital, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8330 · Cited by 324
T Cell Dysfunction in Cancer Immunity and Immunotherapy
Xia, A., Zhang, Y., Jiang, X., Yin, T., & Lu, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01719 · Cited by 344
Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development
Takimoto, T., Wakabayashi, Y., Sekiya, T., Inoue, N., Morita, R., Ichiyama, K., Takahashi, R., Asakawa, M., Muto, G., Mori, T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904100 · Cited by 357
Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation
Takemoto, N., Intlekofer, A. M., Northrup, J. T., Wherry, E. J., & Reiner, S. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7515 · Cited by 339
Self-citation
Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells
Araki, Y., Wang, Z., Zang, C., Wood, W. H., Schones, D. E., Cui, K., Roh, T., Lhotsky, B., Wersto, R. P., Peng, W., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.006 · Cited by 331
FOXO transcription factors throughout T cell biology
Hedrick, S. M., Michelini, R. H., Doedens, A. L., Goldrath, A. W., & Stone, E. L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3278 · Cited by 347
A common variant on chromosome 11q13 is associated with atopic dermatitis
Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.347 · Cited by 317
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
Hinrichs, C. S., Borman, Z. A., Gattinoni, L., Yu, Z., Burns, W. R., Huang, J., Klebanoff, C. A., Johnson, L. A., Kerkar, S. P., Yang, S., et al. (2010) · Blood · doi:10.1182/blood-2010-05-286286 · Cited by 309
Self-citation
Dengue virus infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity
Weiskopf, D., Bangs, D. J., Sidney, J., Kolla, R. V., Silva, A. D. D., de Silva, A. M., Crotty, S., Peters, B., & Sette, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505956112 · Cited by 312
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
Rubtsova, K., Rubtsov, A. V., van Dyk, L. F., Kappler, J. W., & Marrack, P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312348110 · Cited by 300
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection
Buggert, M., Tauriainen, J., Yamamoto, T., Frederiksen, J., Ivarsson, M. A., Michaëlsson, J., Lund, O., Hejdeman, B., Jansson, M., Sönnerborg, A. B., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004251 · Cited by 293
Recent developments in the transcriptional regulation of cytolytic effector cells
Glimcher, L. H., Townsend, M. J., Sullivan, B. M., & Lord, G. M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1490 · Cited by 293
Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells
Yu, J., Wei, M., Becknell, B., Trotta, R., Liu, S., Boyd, Z. S., Jaung, M., Blaser, B. W., Sun, J. P., Benson, D. M., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.016 · Cited by 288
Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model
Chen, S., Lee, L., Fisher, T. S., Jessen, B. A., Elliott, M., Evering, W., Logronio, K. A., Tu, G. H., Tsaparikos, K. E., Li, X., et al. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0118 · Cited by 287
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Boland, B. S., He, Z., Tsai, M. S., Olvera, J. G., Omilusik, K. D., Duong, H. G., Kim, E. S., Limary, A. E., Jin, W., Milner, J. J., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb4432 · Cited by 278
Sorting Through Subsets
Klebanoff, C. A., Gattinoni, L., & Restifo, N. P. (2012) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31827806e6 · Cited by 280
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy
Milner, J. J., Toma, C., He, Z., Kurd, N. S., Nguyen, Q., McDonald, B., Quezada, L. K., Widjaja, C. E., Witherden, D. A., Crowl, J. T., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.007 · Cited by 278
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
Maekawa, Y., Minato, Y., Ishifune, C., Kurihara, T., Kitamura, A., Kojima, H., Yagita∥, H., Sakata‐Yanagimoto, M., Saito, T., Taniuchi, I., et al. (2008) · Nature Immunology · doi:10.1038/ni.1649 · Cited by 269
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17
Rangachari, M., Mauermann, N., Marty, R. R., Dirnhofer, S., Kurrer, M. O., Komnenovic, V., Penninger, J. M., & Eriksson, U. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052222 · Cited by 265
Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis
Patil, V. S., Madrigal, A., Schmiedel, B. J., Clarke, J., O’Rourke, P., de Silva, A. D., Harris, E., Peters, B., Seumois, G., Weiskopf, D., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aan8664 · Cited by 262
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression
Chattopadhyay, P. K., Betts, M. R., Price, D. A., Emma Gostick, D., Horton, H., Roederer, M., & Rosa, S. C. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208107 · Cited by 260
MOLECULAR GENETICS OF T CELL DEVELOPMENT
Rothenberg, E. V., & Taghon, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115737 · Cited by 263
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
Attanasio, J., & Wherry, E. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.022 · Cited by 267
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis
Huber, M., Heink, S., Pagenstecher, A., Reinhard, K., Ritter, J., Visekruna, A., Guralnik, A., Bollig, N., Jeltsch, K. M., Heinemann, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63681 · Cited by 264
Transcriptional regulator Id2 mediates CD8+ T cell immunity
Cannarile, M. A., Lind, N. A., Rivera, R. R., Sheridan, A. D., Camfield, K. A., Wu, B. B., Cheung, K. P., Ding, Z., & Goldrath, A. W. (2006) · Nature Immunology · doi:10.1038/ni1403 · Cited by 250
Micro‐RNA‐155 inhibits IFN‐γ signaling in CD4 + T cells
Banerjee, A., Schambach, F., DeJong, C. S., Hammond, S. M., & Reiner, S. L. (2009) · European Journal of Immunology · doi:10.1002/eji.200939381 · Cited by 252
Self-citation
T-bet in disease
Lazarevic, V., & Glimcher, L. H. (2011) · Nature Immunology · doi:10.1038/ni.2059 · Cited by 255
Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection
Brown, D. M., Lee, S., García-Hernández, M. D. L. L., & Swain, S. L. (2012) · Journal of Virology · doi:10.1128/jvi.07172-11 · Cited by 245
T‐cell tolerance or function is determined by combinatorial costimulatory signals
Nurieva, R., Thomas, S., Nguyen, T. D., Martín‐Orozco, N., Wang, Y., Murali‐Krishna, K., Yu, X., & Dong, C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601146 · Cited by 245
Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation
Joshi, N. S., & Kaech, S. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1309 · Cited by 245
IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease
Mukherjee, S., Lindell, D. M., Berlin, A. A., Morris, S. B., Shanley, T. P., Hershenson, M. B., & Lukacs, N. W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.003 · Cited by 242
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection
Kumaresan, P. R., Manuri, P. R., Albert, N. D., Maiti, S., Singh, H., Mi, T., Roszik, J., Rabinovich, B., Olivares, S., Krishnamurthy, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312789111 · Cited by 237
MAIT Cells in Health and Disease
Provine, N. M., & Klenerman, P. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080719-015428 · Cited by 232
Generation of CD8 T Cell Memory Is Regulated by IL-12
Pearce, E. L., & Shen, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2074 · Cited by 228
Self-citation
A Th17‐like developmental process leads to CD8+ Tc17 cells with reduced cytotoxic activity
Huber, M., Heink, S., Grothe, H., Guralnik, A., Reinhard, K., Elflein, K., Hünig, T., Mittrücker, H., Brüstle, A., Kamradt, T., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200939412 · Cited by 241
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses
Zehn, D., Thimme, R., Lugli, E., de Almeida, G. P., & Oxenius, A. (2022) · Nature Immunology · doi:10.1038/s41590-022-01219-w · Cited by 232
Random migration precedes stable target cell interactions of tumor-infiltrating T cells
Mrass, P., Takano, H., Ng, L. G., Daxini, S. D., Lasaro, M. O., Iparraguirre, A., Cavanagh, L. L., von Andrian, U. H., Ertl, H. C. J., Haydon, P. G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060710 · Cited by 228
Type 17 CD8+ T cells display enhanced antitumor immunity
Hinrichs, C. S., Kaiser, A., Paulos, C. M., Cassard, L., Sanchez-Perez, L. A., Heemskerk, B., Wrzesinski, C., Borman, Z. A., Muranski, P. J., & Restifo, N. P. (2009) · Blood · doi:10.1182/blood-2009-02-203935 · Cited by 226
High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells
Li, J., He, Y., Hao, J., Ni, L., & Dong, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02981 · Cited by 229
SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data
Persad, S., Choo, Z.-N., Dien, C., Sohail, N., Masilionis, I., Chaligné, R., Nawy, T., Brown, C. C., Sharma, R., Pe’er, I., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01716-9 · Cited by 222
IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells
Ćirić, B., Behi, M. E., Cabrera, R., Zhang, G., & Rostami, A. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900036 · Cited by 225
Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses
Konkel, J. E., Zhang, D., Zanvit, P., Chia, C., Zangerle-Murray, T., Jin, W., Wang, S., & Chen, W. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.015 · Cited by 231
TGF-β in T Cell Biology: Implications for Cancer Immunotherapy
Dahmani, A., & Delisle, J. (2018) · Cancers · doi:10.3390/cancers10060194 · Cited by 222
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
Takeuchi, A., Badr, M. E. S. G., Miyauchi, K., Ishihara, C., Onishi, R. M., Guo, Z., Sasaki, Y., Ike, H., Takumi, A., Tsuji, N. M., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150519 · Cited by 220
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells
Li, J., Lee, Y., Li, Y., Jiang, Y. Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.018 · Cited by 213
Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?
Juno, J. A., van Bockel, D., Kent, S. J., Kelleher, A. D., Zaunders, J. J., & Munier, C. M. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00019 · Cited by 195
Plasticity in programming of effector and memory CD8+ T‐cell formation
Arens, R., & Schoenberger, S. P. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00899.x · Cited by 213
The role of programming in memory T-cell development
Masopust, D., Kaech, S. M., Wherry, E. J., & Ahmed, R. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.02.005 · Cited by 205
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
Arsenio, J., Kakaradov, B., Metz, P. J., Kim, S. H., Yeo, G. W.-M., & Chang, J. T. (2014) · Nature Immunology · doi:10.1038/ni.2842 · Cited by 201

Authors: Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., & Reiner, S. L.
Affiliations: Mount Sinai Hospital (CA)
Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author: Reiner, Steven L.
ORCID: Pearce, Erika L.
Mullen, Alan C.
Krawczyk, Connie M.
Mao, Chai-an
Shen, Hao
Cereb, Nezih
Yang, Soo Y.
Rossant, Janet
Hunter, Christopher A.
Reiner, Steven L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-11-07
Volume: 302
Issue: 5647
Pages: 1041-1043
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1090148
OpenAlex: W2119319172
Cited by: 1,014
References: 18
Citations by year: 2026: 25 · 2025: 36 · 2024: 32 · 2023: 47 · 2022: 45 · 2021: 72 · 2020: 60 · 2019: 49 · 2018: 63 · 2017: 33 · 2016: 50 · 2015: 45 · 2014: 56 · 2013: 69 · 2012: 56
FWCI: 8.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM007229, GM-07229)
National Institute of Allergy and Infectious Diseases (AI 042370, R01AI042370)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Eomesodermin, CD8+ T cells, effector T cell differentiation, transcription factors, T-bet, interferon-gamma, perforin, granzyme B, cell-mediated immunity, transcriptional regulation
MeSH terms: T-bet Transcription Factor, Amino Acid Sequence, Animals, Arenaviridae Infections, Base Sequence, Cell Differentiation, Cytotoxicity, Immunologic, Gene Expression Regulation, Interferon-gamma, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Transcription Factors, CD8-Positive T-Lymphocytes, Th2 Cells, T-Box Domain Proteins, Mice, Pore Forming Cytotoxic Proteins, Granzymes, Perforin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks