Cited by 3,444Immune Response and Inflammationinterferon and immune responsesImmunotherapy and Immune Responses

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Diebold, Sandra S., Kaisho, Tsuneyasu, Hemmi, Hiroaki, Akira, Shizuo, Reis e Sousa, Caetano·2004·Science

Open this paper in CoChat — free account

Abstract

Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-alpha in response to the wild-type influenza virus. Here, we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88. Single-stranded RNA (ssRNA) molecules of nonviral origin also induce TLR7-dependent production of inflammatory cytokines. These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses.

Integrity signals

Registry

Crossref · 10.1126/science.1093616

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Toll-Like Receptors
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
Jego, G., Palucka, A. K., Blanck, J.-P., Chalouni, C., Pascual, V., & Banchereau, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00208-5 · Cited by 1,067
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
Asselin‐Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter‐Dambuyant, C., Vicari, A. P., O’Garra, A., Biron, C. A., Brière, F., et al. (2001) · Nature Immunology · doi:10.1038/ni736 · Cited by 1,021
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
Jurk, M., Heil, F., Vollmer, J., Schetter, C., Krieg, A. M., Wagner, H., Lipford, G., & Bauer, S. (2002) · Nature Immunology · doi:10.1038/ni0602-499 · Cited by 838
Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
Cella, M., Facchetti, F., Lanzavecchia, A., & Colonna, M. (2000) · Nature Immunology · doi:10.1038/79747 · Cited by 790
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion
Skehel, J. J., Bayley, P. M., Brown, E. B., Martin, S. R., Waterfield, M. D., White, J. M., Wilson, I. A., & Wiley, D. C. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.4.968 · Cited by 726
Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells
Matsumoto, M., Funami, K., Tanabe, M., Oshiumi, H., Shingai, M., Seto, Y., Yamamoto, A., & Seya, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3154 · Cited by 723
Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells
Nakano, H., Yanagita, M., & Gunn, M. D. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1171 · Cited by 715
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
Krug, A., Luker, G. D., Barchet, W., Leib, D. A., Akira, S., & Colonna, M. (2003) · Blood · doi:10.1182/blood-2003-08-2674 · Cited by 696
CpG‐DNA‐specific activation of antigen‐presenting cells requires stress kinase activity and is preceded by non‐specific endocytosis and endosomal maturation
Häcker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R. M., Sparwasser, T. D., Heeg, K. M., Lipford, G. B., & Wagner, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6230 · Cited by 670

Flagged first, then by citations

Show all 24 references

Research works printed but not linked: 3

Wkly. Epidemiol. Rec. No. 78 (2003), p. 39.
C. Reis e Sousa, Semin. Immunol.16, 24 (2004).
This work was funded by Cancer Research UK. We thank J. Skehel for providingstrain X31 for RNA isolation; M. Albert for wild-type PR8 flu; A. Grassauer and H. Unger for the ΔNS1 flu; A. Steinkasserer for pGEM4Z/GFP; G. Schiavo and G. Hammond for help with liposome preparation; and F. Batista I. Kerr J. Skehel R. Treisman and members of the Immunobiology Laboratory for advice and critical review of the manuscript.

Sorted by citations

Items 601–700 of 1,013

Herpes Simplex Virus Evasion of Early Host Antiviral Responses
Tognarelli, E. I., Palomino, T. F., Corrales, N., Bueno, S. M., Kalergis, A. M., & González, P. A. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00127 · Cited by 145
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity
Liu, G., & Gack, M. U. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.017 · Cited by 148
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity
Tsai, S. J., Atai, N. A., Cacciottolo, M., Nice, J., Salehi, A., Guo, C., Sedgwick, A., Kanagavelu, S., & Gould, S. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101266 · Cited by 142
Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides
Zwiorek, K., Bourquin, C., Battiany, J., Winter, G., Endres, S., Hartmann, G., & Coester, C. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9410-5 · Cited by 141
Bronchial epithelium as a target for innovative treatments in asthma
Gras, D., Chanez, P., Vachier, I., Petit, A., & BOURDIN, A. A. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.008 · Cited by 146
A novel immune biomarker IFI27 discriminates between influenza and bacteria in patients with suspected respiratory infection
Tang, B. M. P., Shojaei, M., Parnell, G. P., Huang, S., Nalos, M., Teoh, S., O'Connor, K. S., Schibeci, S. D., Phu, A. L., Kumar, A., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02098-2016 · Cited by 141
Interferon-α in systemic lupus erythematosus
Crow, M. K., & Kirou, K. A. (2004) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000135453.70424.1b · Cited by 141
Induction of type I interferon by RNA viruses: cellular receptors and their substrates
Baum, A., & García‐Sastre, A. (2009) · Amino Acids · doi:10.1007/s00726-009-0374-0 · Cited by 141
Toll-Like Receptor 3 Signaling on Macrophages Is Required for Survival Following Coxsackievirus B4 Infection
Richer, M. J., Lavallée, D. J., Shanina, I., & Horwitz, M. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004127 · Cited by 140
TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG
Zhang, Z., Guo, J., Li, S., Wu, X., Cao, D., Jiang, B., Jing, P.-B., Bai, X.-Q., Li, C., Wu, Z.-H., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180800 · Cited by 139
Long noncoding RNAs in viral infections
Fortes, P., & Morris, K. V. (2015) · Virus Research · doi:10.1016/j.virusres.2015.10.002 · Cited by 135
Toll-like receptors: key players in antiviral immunity
Arpaia, N., & Barton, G. M. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.006 · Cited by 140
Toll-Like Receptor Polymorphisms, Inflammatory and Infectious Diseases, Allergies, and Cancer
Medvedev, A. E. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0140 · Cited by 140
Mucosal IgA responses in influenza virus infections; thoughts for vaccine design
van Riet, E., Ainai, A., Suzuki, T., & Hasegawa, H. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.04.109 · Cited by 138
Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll‐like receptor 9 dependent T helper type 2 biased immune stimulation
Vollmer, J., Weeratna, R. D., Jurk, M., Samulowitz, U., McCluskie, M. J., Payette, P., Davis, H. L., Schetter, C., & Krieg, A. Μ. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01962.x · Cited by 137
Ikaros is required for plasmacytoid dendritic cell differentiation
Allman, D., Dalod, M., Asselin‐Paturel, C., Delale, T., Robbins, S. H., Trinchieri, G., Biron, C. A., Kastner, P., & Chan, S. H. (2006) · Blood · doi:10.1182/blood-2006-03-007757 · Cited by 138
The Asp299Gly Polymorphism Alters TLR4 Signaling by Interfering with Recruitment of MyD88 and TRIF
Figueroa, L., Xiong, Y., Song, C. H., Piao, W., Vogel, S. N., & Medvedev, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200202 · Cited by 138
Mammalian toll-like receptors: from endogenous ligands to tissue regeneration
Zhang, Z., & Schluesener, H. J. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6189-1 · Cited by 136
Localization of TLR2 and MyD88 to Chlamydia trachomatis Inclusions
O’Connell, C. M., Ionova, I. A., Quayle, A. J., Visintin, A., & Ingalls, R. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510182200 · Cited by 137
IRAK‐M mediates Toll‐like receptor/IL‐1R‐induced NFκB activation and cytokine production
Zhou, H., Yu, M., Fukuda, K., Im, J., Yao, P., Cui, W., Bulek, K., Zepp, J. A., Wan, Y., Kim, T. W., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.2 · Cited by 136
Type III Interferons in Viral Infection and Antiviral Immunity
Zhou, J.-H., Wang, Y., Chang, Q., Ma, P., Hu, Y., & Cao, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495172 · Cited by 134
Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration
Webb, K., Peckham, H., Radziszewska, A., Menon, M., Oliveri, P., Simpson, F., Deakin, C. T., Lee, S. H., Ciurtin, C., Butler, G. E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03167 · Cited by 143
Unpacking extracellular vesicles: RNA cargo loading and function
Dellar, E. R., Hill, C., Melling, G. E., Carter, D. R. F., & Baena-López, L. A. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.40 · Cited by 145
The role of type I interferons in TLR responses
Noppert, S. J., Fitzgerald, K. A., & Hertzog, P. J. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100099 · Cited by 135
The Interaction Between Two Worlds: MicroRNAs and Toll-Like Receptors
Bayraktar, R., Bertilaccio, M. T. S., & Calin, G. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01053 · Cited by 139
Microbiota-derived acetate enhances host antiviral response via NLRP3
Niu, J., Cui, M., Yang, X., Li, J., Yao, Y., Guo, Q., Lu, A., Qi, X., Zhou, D., Zhang, C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36323-4 · Cited by 140
Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease
Obare, L. M., Temu, T. M., Mallal, S. A., & Wanjalla, C. N. (2024) · Circulation Research · doi:10.1161/circresaha.124.323891 · Cited by 150
Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease
Mitchell, J. A., Paul‐Clark, M. J., Clarke, G. W., McMaster, S. K., & Cartwright, N. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0067 · Cited by 137
Targeting the TLR9–MyD88 pathway in the regulation of adaptive immune responses
Huang, X., & Yang, Y. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.501333 · Cited by 121
Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors
Dembny, P., Newman, A. G., Singh, M., Hinz, M., Szczepek, M., Krüger, C., Adalbert, R., Dzaye, O., Trimbuch, T., Wallach, T., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.131093 · Cited by 134
Viral recognition and the antiviral interferon response
Dalskov, L., Gad, H. H., & Hartmann, R. (2023) · The EMBO Journal · doi:10.15252/embj.2022112907 · Cited by 139
Toll-Like Receptor-7 Modulates Immune Complex Glomerulonephritis
Pawar, R. D., Patole, P. S., Zecher, D., Segerer, S., Kretzler, M., Schlöndorff, D., & Anders, H. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005070714 · Cited by 133
Menstrual cycle-dependent changes of Toll-like receptors in endometrium
Aflatoonian, R., Tuckerman, E. M., Elliott, S. L., Bruce, C., D, A. A. M., Li, T. C., & Fazeli, A. (2006) · Human Reproduction · doi:10.1093/humrep/del388 · Cited by 133
Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7
Daffis, S., Suthar, M. S., Szretter, K. J., Gale, M., & Diamond, M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000607 · Cited by 133
High ambient temperature dampens adaptive immune responses to influenza A virus infection
Moriyama, M., & Ichinohe, T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815029116 · Cited by 133
Innate Immune Responses to Acute Viral Infection During Pregnancy
Cornish, E. F., Filipovic, I., Åsenius, F., Williams, D. J., & McDonnell, T. C. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572567 · Cited by 149
The Interleukin‐1 Receptor Family
Boraschi, D., & Tagliabue, A. (2006) · Vitamins & Hormones · doi:10.1016/s0083-6729(06)74009-2 · Cited by 133
Recent Advances in Dendritic Cell Biology
Adams, S., O’Neill, D. W., & Bhardwaj, N. (2005) · Journal of Clinical Immunology · doi:10.1007/s10875-005-2814-2 · Cited by 134
Antigen co‐encapsulated with adjuvants efficiently drive protective T cell immunity
Heit, A., Schmitz, F., Haas, T. L., Busch, D. H., & Wagner, H. (2007) · European Journal of Immunology · doi:10.1002/eji.200737169 · Cited by 136
A comprehensive map of the influenza A virus replication cycle
Matsuoka, Y., Matsumae, H., Katoh, M., Eisfeld, A. J., Neumann, G., Hase, T., Ghosh, S., Shoemaker, J. E., Lopes, T. J. S., Watanabe, T., et al. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-97 · Cited by 138
Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral Response
Paun, A., Reinert, J. T., Jiang, Z., Medin, C. L., Balkhi, M. Y., Fitzgerald, K. A., & Pitha, P. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800501200 · Cited by 132
TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice
Desnues, B., Macedo, A. B., Roussel‐Queval, A., Bonnardel, J., Henri, S., Demaria, O., & Alexopoulou, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314121111 · Cited by 131
Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo
Gitlin, L., Benoît, L. A., Song, C., Cella, M., Gilfillan, S., Holtzman, M. J., & Colonna, M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000734 · Cited by 128
Structural Biology of Innate Immunity
Yin, Q., Fu, T., Li, J., & Wu, H. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112258 · Cited by 135
Chitosan in Non-Viral Gene Delivery: Role of Structure, Characterization Methods, and Insights in Cancer and Rare Diseases Therapies
Santos-Carballal, B., Fernández, E. F., & Goycoolea, F. M. (2018) · Polymers · doi:10.3390/polym10040444 · Cited by 136
Antisense and siRNA as agonists of Toll-like receptors
Agrawal, S., & Kandimalla, E. R. (2004) · Nature Biotechnology · doi:10.1038/nbt1042 · Cited by 132
Toll‐like receptors and pregnancy: Trophoblast as modulators of the immune response
Koga, K., Aldo, P. B., & Mor, G. (2009) · Journal of Obstetrics and Gynaecology Research · doi:10.1111/j.1447-0756.2008.00963.x · Cited by 130
Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.
Karikó, K., & Weissman, D. (2007) · PubMed · Cited by 130
Toll-like receptor signaling controls reactivation of KSHV from latency
Gregory, S. M., West, J. A., Dillon, P., Hilscher, C., Dittmer, D. P., & Damania, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905316106 · Cited by 130
Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase
Doyle, S., Jefferies, C. A., Feighery, C., & O'Neill, L. A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707682200 · Cited by 137
Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model
Dowall, S., Bosworth, A., Watson, R. J., Bewley, K. R., Taylor, I., Rayner, E. L., Hunter, L. E., Pearson, G., Easterbrook, L., Pitman, J. K., et al. (2015) · Journal of General Virology · doi:10.1099/jgv.0.000309 · Cited by 127
mRNA as novel technology for passive immunotherapy
Schlake, T., Theß, A., Thran, M., & Jordan, I. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2935-4 · Cited by 135
Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract
Nasu, K., & Narahara, H. (2010) · Mediators of Inflammation · doi:10.1155/2010/976024 · Cited by 133
Recognition of viral single-stranded RNA by Toll-like receptors☆
Diebold, S. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.004 · Cited by 131
Type I interferons and the innate immune response--more than just antiviral cytokines.
Smith, P., Lombardi, G., & Foster, G. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2004.11.008 · Cited by 133
Toll-like Receptor 4 Signaling Regulates Cytosolic Phospholipase A2 Activation and Lipid Generation in Lipopolysaccharide-stimulated Macrophages
Qi, H., & Shelhamer, J. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509352200 · Cited by 130
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines
Taura, M., Eguma, A., Suico, M. A., Shuto, T., Koga, T., Komatsu, K., Komune, T., Sato, T., Saya, H., Li, J.-D., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01202-08 · Cited by 129
Exosomes, endogenous retroviruses and toll-like receptors: pregnancy recognition in ewes
Ruiz-González, I., Xu, J., Wang, X., Burghardt, R. C., Dunlap, K. A., & Bazer, F. W. (2014) · Reproduction · doi:10.1530/rep-14-0538 · Cited by 128
Activation of the TLR3 pathway regulates IFNβ production in chickens
Karpala, A. J., Lowenthal, J. W., & Bean, A. G. D. (2007) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2007.08.004 · Cited by 132
TH1 Immune Responses to Fully MHC Mismatched Allografts are Diminished in the Absence of MyD88, a Toll-Like Receptor Signal Adaptor Protein
Tesar, B. M., Zhang, J., Li, Q., & Goldstein, D. R. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00544.x · Cited by 128
Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination
Balkhi, M. Y., Fitzgerald, K. A., & Pitha, P. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00662-08 · Cited by 128
Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach
Lambert, N. D., Ovsyannikova, I. G., Pankratz, V. S., Jacobson, R. M., & Poland, G. A. (2012) · Expert Review of Vaccines · doi:10.1586/erv.12.61 · Cited by 127
TLR Activation of Langerhans Cell-Like Dendritic Cells Triggers an Antiviral Immune Response
Renn, C. N., Sanchez, D. J., Ochoa, M. T., Legaspi, A. J., Oh, C., Liu, P. T., Krutzik, S. R., Sieling, P. A., Cheng, G., & Modlin, R. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.298 · Cited by 127
TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts
Thornley, T. B., Brehm, M. A., Markees, T. G., Shultz, L. D., Mordes, J. P., Welsh, R. M., Rossini, A. A., & Greiner, D. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1561 · Cited by 126
The Toll-Like Receptor 7 (TLR7) Agonist, Imiquimod, and the TLR9 Agonist, CpG ODN, Induce Antiviral Cytokines and Chemokines but Do Not Prevent Vaginal Transmission of Simian Immunodeficiency Virus When Applied Intravaginally to Rhesus Macaques
Wang, Y., Abel, K., Lantz, K., Krieg, A. Μ., McChesney, M. B., & Miller, C. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.14355-14370.2005 · Cited by 127
The mucosal immune system of the respiratory tract
Sato, S., & Kiyono, H. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.03.009 · Cited by 135
Toll-Like Receptors in Atherosclerosis
Falck-Hansen, M., Kassiteridi, C., & Monaco, C. G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714008 · Cited by 128
Immune functions of the skin
Bangert, C., Brunner, P. M., & Stingl, G. (2011) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.01.006 · Cited by 135
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice
Patole, P. S., Pawar, R. D., Lech, M., Zecher, D., Schmidt, H., Segerer, S., Ellwart, A., Henger, A., Kretzler, M., & Anders, H. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl336 · Cited by 125
Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies
Fukuyama, S., Katsura, H., Zhao, D., Ozawa, M., Ando, T., Shoemaker, J. E., Ishikawa, I., Yamada, S., Neumann, G., Watanabe, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7600 · Cited by 125
Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon‐α via toll‐like receptor 9
Tversky, J. R., Le, T. V., Bieneman, A. P., Chichester, K. L., Hamilton, R. G., & Schroeder, J. T. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02954.x · Cited by 125
Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin
Raetz, M. M., Кибардин, А. В., Sturge, C. R., Pifer, R., Li, H., Burstein, E., Ozato, K., Larin, S. S., & Yarovinsky, F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301301 · Cited by 125
Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling
Zhang, Q., & Yoo, D. (2016) · Virus Research · doi:10.1016/j.virusres.2016.05.015 · Cited by 123
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
Decalf, J., Fernandes, S., Longman, R., Ahloulay, M., Audat, F., Lefrerre, F., Rice, C. M., Pol, S., & Albert, M. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070814 · Cited by 125
Synthetic agonists of Toll-like receptors 7, 8 and 9
Agrawal, S., & Kandimalla, E. R. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351461 · Cited by 128
Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells
Thompson, D. B., Cronican, J. J., & Liu, D. R. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-396962-0.00012-4 · Cited by 124
Synthetic nanovaccines for immunotherapy
Luo, M., Samandi, L. Z., Wang, Z., Chen, Z. J., & Gao, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.033 · Cited by 126
Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections
Zúñiga, E. I., Liou, L., Mack, L. A., Mendoza, M., & Oldstone, M. B. A. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.08.016 · Cited by 121
Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria
Franklin, B. S., Ishizaka, S. T., Lamphier, M. S., Gusovsky, F., Hansen, H. F., Rose, J., Zheng, W., Ataide, M. A., de Oliveira, R. B., Golenbock, D. T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015406108 · Cited by 123
Toll-Like Receptor 4 Stimulation Initiates an Inflammatory Response That Decreases Cardiomyocyte Contractility
Avlas, O., Fallach, R., Shainberg, A., Porat, E. E., & Hochhauser, E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3728 · Cited by 123
Differential Type I IFN-Inducing Abilities of Wild-Type versus Vaccine Strains of Measles Virus
Shingai, M., Ebihara, T., Begum, N. A., Kato, A., Honma, T., Matsumoto, K., Saito, H., Ogura, H., Matsumoto, M., & Seya, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6123 · Cited by 124
Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes
Patinote, C., Karroum, N. B., Moarbess, G., Cirnat, N., Kassab, I., Bonnet, P., & Deleuze‐Masquéfa, C. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112238 · Cited by 127
Protein N-myristoylation: functions and mechanisms in control of innate immunity
Wang, B., Dai, T., Sun, W., Wei, Y., Ren, J., Zhang, L., Zhang, M., & Zhou, F. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00663-2 · Cited by 128
Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious Diseases
Yang, J., Tseng, J., Yu, G., Luo, Y., Huang, C. F., Hong, Y., & Chuang, T. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020423 · Cited by 129
Regulation of Intestinal Dendritic Cell Migration and Activation by Plasmacytoid Dendritic Cells, TNF-α and Type 1 IFNs after Feeding a TLR7/8 Ligand
Yrlid, U., Milling, S. W. F., Miller, J. L., Cartland, S. P., Jenkins, C. D., & MacPherson, G. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5205 · Cited by 123
Pleiotropic function of Toll-like receptors
Kaisho, T., & Akira, S. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.08.019 · Cited by 123
The interplay between viruses and innate immune signaling: Recent insights and therapeutic opportunities
Unterholzner, L., & Bowie, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.043 · Cited by 125
Rac1 and PAK1 are upstream of IKK‐ε and TBK‐1 in the viral activation of interferon regulatory factor‐3
Ehrhardt, C., Kardinal, C., Wurzer, W. J., Wolff, T., von Eichel‐Streiber, C., Pleschka, S., Planz, O., & Ludwig, S. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.04.069 · Cited by 123
Recognition of Borrelia burgdorferi , the Lyme Disease Spirochete, by TLR7 and TLR9 Induces a Type I IFN Response by Human Immune Cells
Petzke, M. M., Brooks, A., Krupna, M. A., Mordue, D. G., & Schwartz, I. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901390 · Cited by 122
Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System
Sakurai, Y., Hatakeyama, H., Sato, Y., Hyodo, M., Akita, H., & Harashima, H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.57 · Cited by 124
Toll‐like Receptors at the Maternal‐Fetal Interface in Normal Pregnancy and Pregnancy Complications
Koga, K., Izumi, G., Mor, G., Fujii, T., & Osuga, Y. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12258 · Cited by 122
TLR7 induces anergy in human CD4+ T cells
Dominguez‐Villar, M., Gautron, A.-S., de Marcken, M., Keller, M. J., & Hafler, D. A. (2014) · Nature Immunology · doi:10.1038/ni.3036 · Cited by 128
PRRs are watching you: Localization of innate sensing and signaling regulators
Chow, J., Franz, K. M., & Kagan, J. C. (2015) · Virology · doi:10.1016/j.virol.2015.02.051 · Cited by 128
Principles of Virus Uncoating: Cues and the Snooker Ball
Yamauchi, Y., & Greber, U. F. (2016) · Traffic · doi:10.1111/tra.12387 · Cited by 127
The role of alternative polyadenylation in the antiviral innate immune response
Jia, X., Yuan, S., Wang, Y., Fu, Y., Ge, Y., Ge, Y., Lan, X., Feng, Y., Qiu, F., Li, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms14605 · Cited by 122
Dendritic cell recruitment and activation in autoimmunity
Sozzani, S., Prete, A. D., & Bosisio, D. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.07.012 · Cited by 122
Chronic Asthma–induced Airway Remodeling Is Prevented by Toll-like Receptor-7/8 Ligand S28463
Camateros, P., Tamaoka, M., Hassan, M., Marino, R., Moisan, J., Marion, D., Guiot, M., Martin, J. G., & Radzioch, D. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-054oc · Cited by 124
Baculovirus-Derived Human Immunodeficiency Virus Type 1 Virus-Like Particles Activate Dendritic Cells and Induce Ex Vivo T-Cell Responses
Buonaguro, L., Tornesello, M. L., Tagliamonte, M., Gallo, R. C., Wang, L., Kamin‐Lewis, R., Abdelwahab, S. F., Lewis, G. K., & Buonaguro, F. M. (2006) · Journal of Virology · doi:10.1128/jvi.00050-06 · Cited by 124
Modified Vaccinia Virus Ankara Induces Toll-Like Receptor-Independent Type I Interferon Responses
Waibler, Z., Anzaghe, M., Ludwig, H., Akira, S., Weiß, S., Sutter, G., & Kalinke, U. (2007) · Journal of Virology · doi:10.1128/jvi.01190-07 · Cited by 122
Progress on the development of therapeutics against West Nile virus
Diamond, M. S. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.05.006 · Cited by 120

Authors: Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C.
Affiliations: Cancer Research UK (GB)
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
ORCID: Diebold, Sandra S.
Kaisho, Tsuneyasu
Hemmi, Hiroaki
Akira, Shizuo
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-03-05
Volume: 303
Issue: 5663
Pages: 1529-1531
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1093616
OpenAlex: W1994391392
Cited by: 3,444
References: 24
Citations by year: 2026: 72 · 2025: 84 · 2024: 93 · 2023: 101 · 2022: 117 · 2021: 136 · 2020: 133 · 2019: 113 · 2018: 115 · 2017: 117 · 2016: 127 · 2015: 135 · 2014: 161 · 2013: 166 · 2012: 169
FWCI: 93.25
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: TLR7, single-stranded RNA, antiviral innate immunity, interferon-alpha, plasmacytoid dendritic cells, influenza virus, MyD88 signaling, RNA virus detection, inflammatory cytokines
MeSH terms: Animals, Antigens, Differentiation, Cells, Cultured, Dendritic Cells, Endocytosis, Immunity, Innate, Ligands, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Influenza A virus, Poly U, Polyribonucleotides, Receptors, Cell Surface, Receptors, Immunologic, Endosomes, RNA, RNA, Viral, Signal Transduction, Cytokines, Genome, Viral, Interferon-alpha, Adaptor Proteins, Signal Transducing, Toll-Like Receptor 7, Mice, Myeloid Differentiation Factor 88

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks