The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Abstract
Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.
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“In OPCs, there was early upregulation of several transcription factors (OLIG1, OLIG2, SOX10, SOX8, PRRX1, ASCL1) and Notch ligands (DLL1, DLL3) known to regulate differentiation78–81 to oligodendrocytes after loss of surrounding oligodendrocytes (Fig. 7e, right, and Fig. 7g).”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [78]
Citations
Cites
Compston, A., & Coles, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08220-x · Cited by 1,743
Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
Barnett, M. H., & Prineas, J. W. (2004) · Annals of Neurology · doi:10.1002/ana.20016 · Cited by 1,184
Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,087
Self-citationThe bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991
Matsushima, G. K., & Morell, P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00385.x · Cited by 984
Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis
Kornek, B., Storch, M. K., Weissert, R., Wallstroem, E., Stefferl, A., Olsson, T. P., Linington, C., Schmidbauer, M., & Lassmann, H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64537-3 · Cited by 935
Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889
Lu, Q. R., Yuk, D.-I., Alberta, J., Zhu, Z.-M., Pawlitzky, I., Chan, J., McMahon, A., Stiles, C., & Rowitch, D. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80897-1 · Cited by 883
Self-citationWhy does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
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- C. S. Raine, in Textbook of Neuropathology, R. L. Davis, D. M. Robertson, Eds. (Williams & Willkins, Baltimore, MD, 1997), pp. 245–287.
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Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Self-citationMultiple sclerosis--the plaque and its pathogenesis.
Frohman, E., Racke, M., & Raine, C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052130 · Cited by 1,793
Self-citationRemyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Self-citationNeuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472
Metadata
- Authors
- Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Arnett, Heather A.
- Fancy, Stephen P. J.
- Franklin, Robin J. M.
- Stiles, Charles D.
- ORCID
- Venue
- Science
- Published
- 2004-12-17
- Volume
- 306
- Issue
- 5704
- Pages
- 2111-2115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064769936
- Cited by
- 416
- References
- 28
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 13 · 2020: 17 · 2019: 21 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 26 · 2014: 35 · 2013: 26 · 2012: 16
- FWCI
- 15.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society
- National Institute of Neurological Disorders and Stroke (NS-08952, NS-11920, NS4051, R01NS008952)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- Olig1, Olig2, bHLH transcription factors, demyelination, multiple sclerosis, myelinating oligodendrocytes, oligodendrocyte precursor cells, central nervous system repair
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Animals, Newborn, Brain, Cell Nucleus, Cuprizone, Cytoplasm, Demyelinating Diseases, DNA-Binding Proteins, Ethidium, Humans, Lysophosphatidylcholines, Mice, Inbred C57BL, Multiple Sclerosis, Myelin Sheath, Nerve Tissue Proteins, Oligodendroglia, Spinal Cord, Stem Cells, Transcription Factors, Rats, Sprague-Dawley, Mice, Rats, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors
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