Broad Conservation of Milk Utilization Genes in Bifidobacterium longum subsp.infantis as Revealed by Comparative Genomic Hybridization
Open accessAbstract
Human milk oligosaccharides (HMOs) are the third-largest solid component of milk. Their structural complexity renders them nondigestible to the host but liable to hydrolytic enzymes of the infant colonic microbiota. Bifidobacteria and, frequently, Bifidobacterium longum strains predominate the colonic microbiota of exclusively breast-fed infants. Among the three recognized subspecies of B. longum, B. longum subsp. infantis achieves high levels of cell growth on HMOs and is associated with early colonization of the infant gut. The B. longum subsp. infantis ATCC 15697 genome features five distinct gene clusters with the predicted capacity to bind, cleave, and import milk oligosaccharides. Comparative genomic hybridizations (CGHs) were used to associate genotypic biomarkers among 15 B. longum strains exhibiting various HMO utilization phenotypes and host associations. Multilocus sequence typing provided taxonomic subspecies designations and grouped the strains between B. longum subsp. infantis and B. longum subsp. longum. CGH analysis determined that HMO utilization gene regions are exclusively conserved across all B. longum subsp. infantis strains capable of growth on HMOs and have diverged in B. longum subsp. longum strains that cannot grow on HMOs. These regions contain fucosidases, sialidases, glycosyl hydrolases, ABC transporters, and family 1 solute binding proteins and are likely needed for efficient metabolism of HMOs. Urea metabolism genes and their activity were exclusively conserved in B. longum subsp. infantis. These results imply that the B. longum has at least two distinct subspecies: B. longum subsp. infantis, specialized to utilize milk carbon, and B. longum subsp. longum, specialized for plant-derived carbon metabolism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human milk oligosaccharides are bioactive compounds and the third largest component of human milk.
“Human milk oligosaccharides (MOS) are bioactive compounds that are the third largest component of human milk10.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP
Felsenstein, J. (1985) · Evolution · doi:10.1111/j.1558-5646.1985.tb00420.x · Cited by 44,735 · see citing works
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J. T., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,734 · see citing works
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Application of Phylogenetic Networks in Evolutionary Studies
Huson, D. H., & Bryant, D. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj030 · Cited by 8,751 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Prospects for inferring very large phylogenies by using the neighbor-joining method
Tamura, K., Nei, M., & Kumar, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404206101 · Cited by 5,588 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,234 · see citing works
Probiotics: an overview of beneficial effects
Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020620607611 · Cited by 1,045 · see citing works
Schell, M. A., Karmirantzou, M., Snel, ., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942 · see citing works
Sela, D. A., Chapman, J., Adeuya, A., Kim, J., Chen, F., Whitehead, T. R., Lapidus, A. L., Rokhsar, D. S., Lebrilla, C. B., German, J. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809584105 · Cited by 884 · see citing works
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
Phylogenetic test of the molecular clock and linearized trees.
Takezaki, N., Rzhetsky, A., & Nei, M. (1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040259 · Cited by 826 · see citing works
ABC transporters: physiology, structure and mechanism – an overview
Higgins, C. F. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01193-7 · Cited by 643 · see citing works
Protection of the Neonate by the Innate Immune System of Developing Gut and of Human Milk
Newburg, D. S., & Walker, W. A. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000250274.68571.18 · Cited by 524 · see citing works
Leptin-specific patterns of gene expression in white adipose tissuePreprint
Soukas, A. A., Cohen, P., Socci, N. D., & Friedman, J. M. (2000) · Genes & Development · doi:10.1101/gad.14.8.963 · Cited by 516 · see citing works
A Strategy for Annotating the Human Milk Glycome
Niñonuevo, M. R., Park, Y., Yin, H., Zhang, J., Ward, R. E., Clowers, B. H., German, J. B., Freeman, S. L., Killeen, K., Grimm, R., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0615810 · Cited by 495 · see citing works
Liévin, V, Peiffer, I., Hudault, S., Rochat, F., Brassart, D., Neeser, J.-R., & Servin, A. L. (2000) · Gut · doi:10.1136/gut.47.5.646 · Cited by 397 · see citing works
LoCascio, R. G., Ninonuevo, M. R., Freeman, S. L., Sela, D. A., Grimm, R., Lebrilla, C. B., Mills, D. A., & German, J. B. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0710480 · Cited by 365 · see citing works
Rzhetsky, A., & Nei, M. (1992) · Journal of Molecular Evolution · doi:10.1007/bf00161174 · Cited by 361 · see citing works
Wada, J., Ando, T., Kiyohara, M., Ashida, H., Kitaoka, M., Yamaguchi, M., Kumagai, H., Katayama, T., & Yamamoto, K. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00149-08 · Cited by 230 · see citing works
Fuller, M. F., & Reeds, P. J. (1998) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.18.1.385 · Cited by 225 · see citing works
Biochemistry and Role of Sialic Acids
Schauer, R., Kelm, S., Reuter, G., Roggentin, P., & Shaw, L. (1995) · Springer eBooks · doi:10.1007/978-1-4757-9504-2_2 · Cited by 223 · see citing works
Large-Scale Clustering of cDNA-Fingerprinting DataPreprint
Herwig, R., Poustka, A. J., Müller, C. H., Bull, C., Lehrach, H. R., & O’Brien, J. (1999) · Genome Research · doi:10.1101/gr.9.11.1093 · Cited by 221 · see citing works
The integrated microbial genomes (IMG) system in 2007: data content and analysis tool extensions
Markowitz, V. M., Szeto, E., Palaniappan, K., Grechkin, Y., Chu, K., Chen, I.-M. A., Dubchak, I. L., Anderson, I., Lykidis, A., Mavromatis, K., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm846 · Cited by 211 · see citing works
The First Prebiotics in Humans
Coppa, G. V., Bruni, S., Morelli, L., Soldi, S., & Gabrielli, O. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128926.14285.25 · Cited by 202 · see citing works
Novel Putative Galactose Operon Involving Lacto-N-Biose Phosphorylase inBifidobacterium longum
Kitaoka, M., Tian, J., & Nishimoto, M. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.6.3158-3162.2005 · Cited by 200 · see citing works
Development of bacterial and bifidobacterial communities in feces of newborn babies
Favier, C. F., de Vos, W. M., & Akkermans, A. D. L. (2003) · Anaerobe · doi:10.1016/j.anaerobe.2003.07.001 · Cited by 194 · see citing works
Nishimoto, M., & Kitaoka, M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01425-07 · Cited by 194 · see citing works
Lee, J.-H., Karamychev, V., Kozyavkin, S. A., Mills, D. A., Pavlov, A., Pavlova, N. V., Polouchine, N., Richardson, P., Shakhova, V. V., Slesarev, A. I., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-247 · Cited by 181 · see citing works
Kleessen, B., Bunke, H., Tovar, K., Noack, J., & Sawatzki, G. (1995) · Acta Paediatrica · doi:10.1111/j.1651-2227.1995.tb13567.x · Cited by 179 · see citing works
Analysis of bifidobacterial evolution using a multilocus approach
Ventura, M., Canchaya, C. A., Casale, A. D., Dellaglio, F., Neviani, E., Fitzgerald, G. F., & van Sinderen, D. (2006) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.64233-0 · Cited by 158 · see citing works
Cai, H., Rodriguez, B. T., Zhang, W., Broadbent, J. R., & Steele, J. L. (2007) · Microbiology · doi:10.1099/mic.0.2007/006452-0 · Cited by 148 · see citing works
Complete Genome Sequence of Bifidobacterium longum subsp. longum KACC 91563
Ham, J.-S., Lee, T., Byun, M.-J., Lee, K., Kim, M., Han, G.-S., Jeong, S.-G., Oh, M., Kim, D., & Kim, H. (2011) · Journal of Bacteriology · doi:10.1128/jb.05620-11 · Cited by 143 · see citing works
LoCascio, R. G., Niñonuevo, M. R., Kronewitter, S. R., Freeman, S. L., German, J. B., Lebrilla, C. B., & Mills, D. A. (2008) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00072.x · Cited by 140 · see citing works
Survival of Human Milk Oligosaccharides in the Intestine of Infants
Chaturvedi, P., Warren, C. D., Buescher, C., Pickering, L. K., & Newburg, D. S. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1371-1_39 · Cited by 124 · see citing works
Unification of Bifidobacterium infantis and Bifidobacterium suis as Bifidobacterium longum.
Sakata, S., Kitahara, M., Sakamoto, M., Hayashi, H., Fukuyama, M., & Benno, Y. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-6-1945 · Cited by 111 · see citing works
Mattarelli, P., Bonaparte, C., Pot, B., & Biavati, B. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65319-0 · Cited by 106 · see citing works
Bioactive Components of Human Milk
Newburg, D. S. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1371-1_1 · Cited by 102 · see citing works
GONZALEZ, R., Klaassens, E. S., Malinen, E., de Vos, W. M., & Vaughan, E. E. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00122-08 · Cited by 92 · see citing works
EU project Crownalife: functional foods, gut microflora and healthy ageing
Silvi, S., Verdenelli, M. C., Orpianesi, C., & Cresci, A. (2002) · Journal of Food Engineering · doi:10.1016/s0260-8774(02)00249-2 · Cited by 87 · see citing works
Non‐Protein Nitrogen and True Protein in Infant Formulas
Donovan, S. M., & Lönnerdal, B. L. (1989) · Acta Paediatrica · doi:10.1111/j.1651-2227.1989.tb17927.x · Cited by 84 · see citing works
Delétoile, A., Passet, V., Aires, J., Chambaud, I., Butel, M., Smokvina, T., & Brisse, S. (2010) · Research in Microbiology · doi:10.1016/j.resmic.2009.12.006 · Cited by 74 · see citing works
Comparative genomic analysis of Mycobacterium avium subspecies obtained from multiple host species
Paustian, M. L., Zhu, X., Sreevatsan, S., Robbe‐Austerman, S., Kapur, V., & Bannantine, J. P. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-135 · Cited by 60 · see citing works
Urease production by Streptococcus thermophilus
Zotta, T., Ricciardi, A., Rossano, R., & Parente, E. (2007) · Food Microbiology · doi:10.1016/j.fm.2007.07.001 · Cited by 51 · see citing works
Taboada, E. N., Acedillo, R. R., Luebbert, C., Findlay, W. A., & Nash, J. H. E. (2005) · BMC Genomics · doi:10.1186/1471-2164-6-78 · Cited by 34 · see citing works
Improved analysis of bacterial CGH data beyond the log-ratio paradigm
Snipen, L. G., Nyquist, O. L., Solheim, M., Aakra, Å., & Nes, I. F. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-91 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
How glycan metabolism shapes the human gut microbiota
Koropatkin, N. M., Cameron, E. A., & Martens, E. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2746 · Cited by 1,419 · see citing works
Bifidobacteria-mediated immune system imprinting early in life
Henrick, B. M., Rodriguez, L., Lakshmikanth, T., Pou, C., Henckel, E., Arzoomand, A., Olin, A., Wang, J., Mikeš, J., Tan, Z., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.030 · Cited by 808 · see citing works
The human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720 · see citing works
Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606 · see citing works
Charbonneau, M. R., O’Donnell, D., Blanton, L. V., Totten, S. M., Davis, J. C. C., Barratt, M. J., Cheng, J., Guruge, J., Talcott, M., Bain, J. R., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.024 · Cited by 606 · see citing works
Self-citationPhysiology of Consumption of Human Milk Oligosaccharides by Infant Gut-associated Bifidobacteria
Asakuma, S., Hatakeyama, E., Urashima, T., Yoshida, E., Katayama, T., Yamamoto, K., Kumagai, H., Ashida, H., Hirose, J., & Kitaoka, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248138 · Cited by 442 · see citing works
Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut
Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015) · Pediatric Research · doi:10.1038/pr.2014.156 · Cited by 439 · see citing works
Human milk oligosaccharide consumption by intestinal microbiota
Marcobal, A. M., & Sonnenburg, J. L. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03863.x · Cited by 311 · see citing works
Chichlowski, M., De Lartigue, G., German, J. B., Raybould, H. E., & Mills, D. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824fb899 · Cited by 276 · see citing works
Jost, T., Lacroix, C., Braegger, C., & Chassard, C. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu016 · Cited by 267 · see citing works
Yu, Z., Chen, C., Kling, D. E., Liu, B., McCoy, J. M., Merighi, M., Heidtman, M. I., & Newburg, D. S. (2012) · Glycobiology · doi:10.1093/glycob/cws138 · Cited by 252 · see citing works
Ruiz‐Moyano, S., Totten, S. M., Garrido, D. A., Smilowitz, J. T., German, J. B., Lebrilla, C. B., & Mills, D. A. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01843-13 · Cited by 238 · see citing works
Frese, S. A., Hutton, A. A., Contreras, L. N., Shaw, C. A., Palumbo, M. C., Casaburi, G., Xu, G., Davis, J. C. C., Lebrilla, C. B., Henrick, B. M., et al. (2017) · mSphere · doi:10.1128/msphere.00501-17 · Cited by 231 · see citing works
Self-citationTannock, G. W., Lawley, B., Munro, K., Pathmanathan, S. G., Zhou, S. J., Makrides, M., Gibson, R. A., Sullivan, T., Prosser, C. G., Lowry, D. J., et al. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03910-12 · Cited by 230 · see citing works
Garrido, D., Dallas, D. C., & Mills, D. A. (2013) · Microbiology · doi:10.1099/mic.0.064113-0 · Cited by 228 · see citing works
Genetic Mechanisms of Prebiotic Oligosaccharide Metabolism in Probiotic Microbes
Goh, Y. J., & Klaenhammer, T. R. (2014) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022814-015706 · Cited by 224 · see citing works
Garrido, D. A., Kim, J., German, J. B., Raybould, H. E., & Mills, D. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017315 · Cited by 218 · see citing works
Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Olm, M. R., Dahan, D., Carter, M. M., Merrill, B. D., Yu, F. B., Jain, S., Meng, X., Tripathi, S. M., Wastyk, H. C., Neff, N. F., et al. (2022) · Science · doi:10.1126/science.abj2972 · Cited by 210 · see citing works
Thongaram, T., Hoeflinger, J. L., Chow, J., & Miller, M. J. (2017) · Journal of Dairy Science · doi:10.3168/jds.2017-12753 · Cited by 215 · see citing works
Sakanaka, M., Gotoh, A., Yoshida, K., Odamaki, T., Koguchi, H., Xiao, J., Kitaoka, M., & Katayama, T. (2019) · Nutrients · doi:10.3390/nu12010071 · Cited by 215 · see citing works
Genomics and ecological overview of the genus Bifidobacterium
Turroni, F., van Sinderen, D., & Ventura, M. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.12.010 · Cited by 197 · see citing works
Human milk and related oligosaccharides as prebiotics
Barile, D., & Rastall, R. A. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.01.008 · Cited by 193 · see citing works
Garrido, D. A., Ruiz‐Moyano, S., Lemay, D. G., Sela, D. A., German, J. B., & Mills, D. A. (2015) · Scientific Reports · doi:10.1038/srep13517 · Cited by 189 · see citing works
Schwab, C., Ruscheweyh, H., Bunešová, V., Pham, V. T., Beerenwinkel, N., & Lacroix, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00095 · Cited by 188 · see citing works
Davis, J. C. C., Lewis, Z. T., Krishnan, S., Bernstein, R. M., Moore, S. E., Prentice, A. M., Mills, D. A., Lebrilla, C. B., & Zivkovic, A. M. (2017) · Scientific Reports · doi:10.1038/srep40466 · Cited by 187 · see citing works
Diet and microbiota linked in health and disease
Requena, T., Martínez‐Cuesta, M. C., & Peláez, C. (2018) · Food & Function · doi:10.1039/c7fo01820g · Cited by 187 · see citing works
Garrido, D. A., Ruiz‐Moyano, S., Kirmiz, N., Davis, J. C. C., Totten, S. M., Lemay, D. G., Ugalde, J. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2016) · Scientific Reports · doi:10.1038/srep35045 · Cited by 185 · see citing works
The Impact of the Milk Glycobiome on the Neonate Gut Microbiota
Pacheco, A. R., Barile, D., Underwood, M. A., & Mills, D. A. (2014) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-111112 · Cited by 181 · see citing works
Bovine Milk as a Source of Functional Oligosaccharides for Improving Human Health
Zivkovic, A. M., & Barile, D. (2011) · Advances in Nutrition · doi:10.3945/an.111.000455 · Cited by 180 · see citing works
Comparative Analysis of 16S rRNA Gene and Metagenome Sequencing in Pediatric Gut Microbiomes
Peterson, D., Bonham, K. S., Rowland, S., Pattanayak, C. W., & Klepac‐Ceraj, V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.670336 · Cited by 178 · see citing works
The Influence of Milk Oligosaccharides on Microbiota of Infants: Opportunities for Formulas
Chichlowski, M., German, J. B., Lebrilla, C. B., & Mills, D. A. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133743 · Cited by 174 · see citing works
Bunešová, V., Lacroix, C., & Schwab, C. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0867-4 · Cited by 173 · see citing works
Barratt, M. J., Nuzhat, S., Ahsan, K., Frese, S. A., Arzamasov, A. A., Sarker, S. A., Islam, M. M., Palit, P., Islam, M. R., Hibberd, M. C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk1107 · Cited by 169 · see citing works
Gotoh, A., Katoh, T., Sakanaka, M., Ling, Y., Yamada, C., Asakuma, S., Urashima, T., Tomabechi, Y., Katayama-Ikegami, A., Kurihara, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32080-3 · Cited by 168 · see citing works
Microbial Urease in Health and Disease
Mora, D., & Arioli, S. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004472 · Cited by 161 · see citing works
Validating bifidobacterial species and subspecies identity in commercial probiotic products
Lewis, Z. T., Shani, G., Masarweh, C. F., Popovic, M., Frese, S. A., Sela, D. A., Underwood, M. A., & Mills, D. A. (2016) · Pediatric Research · doi:10.1038/pr.2015.244 · Cited by 154 · see citing works
Self-citationO’Sullivan, A. M., Farver, M., & Smilowitz, J. T. (2015) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s29530 · Cited by 153 · see citing works
A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract
Garrido, D., Barile, D., & Mills, D. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.001586 · Cited by 149 · see citing works
Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii
Bunešová, V., Lacroix, C., & Schwab, C. (2017) · Microbial Ecology · doi:10.1007/s00248-017-1037-4 · Cited by 149 · see citing works
Alessandri, G., van Sinderen, D., & Ventura, M. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.03.006 · Cited by 147 · see citing works
Yoshida, E., Sakurama, H., Kiyohara, M., Nakajima, M., Kitaoka, M., Ashida, H., Hirose, J., Katayama, T., Yamamoto, K., & Kumagai, H. (2011) · Glycobiology · doi:10.1093/glycob/cwr116 · Cited by 140 · see citing works
Soy and Gut Microbiota: Interaction and Implication for Human Health
Huang, H., Krishnan, H. B., Pham, Q., Yu, L. L., & Wang, T. T. Y. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03725 · Cited by 138 · see citing works
Human milk oligosaccharide categories define the microbiota composition in human colostrum
Aakko, J., Kumar, H., Rautava, S., Wise, A., Autran, C. A., Bode, L., Isolauri, E., & Salminen, S. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0185 · Cited by 136 · see citing works
Galacto-oligosaccharides and colorectal cancer: Feeding our intestinal probiome
Bruno-Bárcena, J. M., & Azcárate-Peril, M. A. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.10.029 · Cited by 127 · see citing works
Beneficial effects of human milk oligosaccharides on gut microbiota
Musilová, Š., Rada, V., Vlková, E., & Bunešová, V. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0080 · Cited by 127 · see citing works
Malmuthuge, N., Chen, Y., Liang, G., Goonewardene, L. A., & Guan, L. L. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9607 · Cited by 131 · see citing works
Chichlowski, M., Shah, N., Wampler, J. L., Wu, S. S., & Vanderhoof, J. A. (2020) · Nutrients · doi:10.3390/nu12061581 · Cited by 122 · see citing works
Bifidobacterial Enzymes Involved in the Metabolism of Human Milk Oligosaccharides
Kitaoka, M. (2012) · Advances in Nutrition · doi:10.3945/an.111.001420 · Cited by 118 · see citing works
Kavanaugh, D. W., O’Callaghan, J., Buttó, L. F., Slattery, H., Lane, J. A., Clyne, M., Kane, M., Joshi, L., & Hickey, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067224 · Cited by 115 · see citing works
Utilization of galactooligosaccharides by Bifidobacterium longum subsp. infantis isolates
Garrido, D. A., Ruiz‐Moyano, S., Jimenez-Espinoza, R., Eom, H., Block, D. E., & Mills, D. A. (2012) · Food Microbiology · doi:10.1016/j.fm.2012.10.003 · Cited by 113 · see citing works
Spevacek, A., Smilowitz, J. T., Chin, E. L., Underwood, M. A., German, J. B., & Slupsky, C. M. (2015) · Journal of Nutrition · doi:10.3945/jn.115.210252 · Cited by 112 · see citing works
Host-Microbe Interactions in the Neonatal Intestine: Role of Human Milk Oligosaccharides
Donovan, S. M., Wang, M., Li, M., Friedberg, I., Schwartz, S., & Chapkin, R. S. (2012) · Advances in Nutrition · doi:10.3945/an.112.001859 · Cited by 107 · see citing works
Wong, C. B., Odamaki, T., & Xiao, J. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa010 · Cited by 106 · see citing works
Bifidobacterial utilization of human milk oligosaccharides
Sela, D. A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.01.025 · Cited by 105 · see citing works
Avershina, E., Storrø, O., Øien, T., Johnsen, R., Wilson, R., Egeland, T., & Rudi, K. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02359-12 · Cited by 101 · see citing works
Garrido, D. A., Ruiz‐Moyano, S., & Mills, D. A. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.04.012 · Cited by 102 · see citing works
Morovic, W., Hibberd, A. A., Zabel, B., Barrangou, R., & Stahl, B. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01747 · Cited by 99 · see citing works
Bifidobacteria and humans: our special friends, from ecological to genomics perspectives
Ventura, M., Turroni, F., Lugli, G. A., & van Sinderen, D. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6356 · Cited by 99 · see citing works
Venema, K. (2011) · International Dairy Journal · doi:10.1016/j.idairyj.2011.10.011 · Cited by 98 · see citing works
Sun, Z., Zhang, W., Guo, C., Yang, X., Liu, W., Wu, Y., Song, Y., Kwok, L. Y., Cui, Y., Menghe, B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117912 · Cited by 97 · see citing works
Effect of intrapartum antibiotics on the intestinal microbiota of infants: a systematic review
Zimmermann, P., & Curtis, N. C. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-316659 · Cited by 97 · see citing works
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning
Vatanen, T., Ang, Q. Y., Siegwald, L., Sarker, S. A., Roy, C. I. L., Duboux, S., Delannoy-Bruno, O., Ngom‐Bru, C., Boulangé, C. L., Stražar, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.10.011 · Cited by 92 · see citing works
Untangling human milk oligosaccharides and infant gut microbiome
Masi, A. C., & Stewart, C. J. (2021) · iScience · doi:10.1016/j.isci.2021.103542 · Cited by 94 · see citing works
Button, J. E., Autran, C. A., Reens, A. L., Cosetta, C. M., Smriga, S., Ericson, M. E., Pierce, J. V., Cook, D. N., Lee, M. L., Sun, A. K., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.001 · Cited by 85 · see citing works
Seppo, A., Bu, K., Jumabaeva, M., Thakar, J., Choudhury, R. A., Yonemitsu, C., Bode, L., Martina, C. A., Allen, M., Tamburini, S., et al. (2021) · Allergy · doi:10.1111/all.14877 · Cited by 80 · see citing works
Vongbhavit, K., & Underwood, M. A. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.01.006 · Cited by 79 · see citing works
Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal
James, K., Bottacini, F., Serrano-Contreras, J. I., Vigoureux, M., Egan, M., Motherway, M. O., Holmes, E. C., & van Sinderen, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-51901-7 · Cited by 76 · see citing works
Casaburi, G., Duar, R. M., Brown, H. K., Mitchell, R. D., Kazi, S., Chew, S., Cagney, O., Flannery, R. L., Sylvester, K. G., Frese, S. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80583-9 · Cited by 75 · see citing works
Soy bioactive peptides and the gut microbiota modulation
Ashaolu, T. J. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10799-2 · Cited by 72 · see citing works
Duar, R. M., Casaburi, G., Mitchell, R. D., Scofield, L. N. C., Ramírez, C. A. O., Barile, D., Henrick, B. M., & Frese, S. A. (2020) · Nutrients · doi:10.3390/nu12113247 · Cited by 70 · see citing works
Zabel, B., Gerdes, S., Evans, K. C., Nedveck, D. A., Singles, S. K., Volk, B., & Budinoff, C. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-72792-z · Cited by 71 · see citing works
Colonization and probiotic function of Bifidobacterium longum
Zhang, C., Yu, Z., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.022 · Cited by 70 · see citing works
Factors Influencing the Intestinal Microbiome During the First Year of Life
Zimmermann, P., & Curtis, N. C. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002103 · Cited by 68 · see citing works
O’Brien, C. E., Meier, A., Cernioglo, K., Mitchell, R. D., Casaburi, G., Frese, S. A., Henrick, B. M., Underwood, M. A., & Smilowitz, J. T. (2021) · Pediatric Research · doi:10.1038/s41390-020-01350-0 · Cited by 66 · see citing works
Kiely, L. J., Busca, K., Lane, J. A., van Sinderen, D., & Hickey, R. M. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad056 · Cited by 63 · see citing works
Laursen, M. F., & Roager, H. M. (2023) · The ISME Journal · doi:10.1038/s41396-023-01525-7 · Cited by 63 · see citing works
Adaptation of bifidobacteria to the gastrointestinal tract and functional consequences
Sánchez, B., Ruíz, L., Gueimonde, M., Ruas‐Madiedo, P., & Margollés, A. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.004 · Cited by 64 · see citing works
Henrick, B. M., Yao, X.-D., Nasser, L., Roozrogousheh, A., & Rosenthal, K. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01631 · Cited by 84 · see citing works
Complex Oligosaccharide Utilization Pathways in Lactobacillus
Zúñiga, M., Yebra, M. J., & Monedero, V. (2020) · Current Issues in Molecular Biology · doi:10.21775/cimb.040.049 · Cited by 62 · see citing works
Ennis, D., Shmorak, S., Jantscher‐Krenn, E., & Yassour, M. (2024) · Nature Communications · doi:10.1038/s41467-024-45209-y · Cited by 61 · see citing works
Leong, A., Liu, Z., Almshawit, H., Zisu, B., Pillidge, C. J., Rochfort, S. J., & Gill, H. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900134x · Cited by 59 · see citing works
(2014) · Wiley eBooks · doi:10.1002/9781118817360 · Cited by 56 · see citing works
Differential Establishment of Bifidobacteria in the Breastfed Infant Gut
Lewis, Z. T., & Mills, D. A. (2017) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000455399 · Cited by 56 · see citing works
Özcan, E., & Sela, D. A. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00046 · Cited by 56 · see citing works
Smilowitz, J. T., Allen, L. H., Dallas, D. C., McManaman, J. L., Raiten, D. J., Rozga, M., Sela, D. A., Seppo, A., Williams, J. E., Young, B. E., et al. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2022.11.027 · Cited by 55 · see citing works
O’Riordan, N., O’Callaghan, J., Buttó, L. F., Kilcoyne, M., Joshi, L., & Hickey, R. M. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-14499 · Cited by 55 · see citing works
Wong, C. B., Huang, H., Ning, Y., & Xiao, J. (2024) · Microorganisms · doi:10.3390/microorganisms12051014 · Cited by 56 · see citing works
Bifidobacteria-Host Interactions—An Update on Colonisation Factors
Grimm, V., Westermann, C., & Riedel, C. U. (2014) · BioMed Research International · doi:10.1155/2014/960826 · Cited by 54 · see citing works
Lactation and Intestinal Microbiota: How Early Diet Shapes the Infant Gut
Goldsmith, F., O’Sullivan, A. M., Smilowitz, J. T., & Freeman, S. L. (2015) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-015-9335-2 · Cited by 54 · see citing works
A Human Gut Commensal Ferments Cranberry Carbohydrates To Produce Formate
Özcan, E., Sun, J., Rowley, D. C., & Sela, D. A. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01097-17 · Cited by 53 · see citing works
Human Milk Oligosaccharides: A Comprehensive Review towards Metabolomics
Corona, L., Lussu, A., Bosco, A., Pintus, R., Marincola, F. C., Fanos, V., & Dessì, A. (2021) · Children · doi:10.3390/children8090804 · Cited by 54 · see citing works
Weimer, B. C. (2017) · Genome Announcements · doi:10.1128/genomea.00594-17 · Cited by 51 · see citing works
Arzamasov, A. A., Rodionov, D. A., Hibberd, M. C., Guruge, J. L., Kent, J. E., Kazanov, M. D., Leyn, S. A., Elane, M. L., Sejane, K., Fürst, A., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02056-x · Cited by 49 · see citing works
Button, J. E., Cosetta, C. M., Reens, A. L., Brooker, S. L., Rowan-Nash, A. D., Lavin, R., Saur, R., Zheng, S., Autran, C. A., Lee, M. L., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.08.004 · Cited by 48 · see citing works
Mora, D., Filardi, R., Arioli, S., Boeren, S. A., Aalvink, S., & de Vos, W. M. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13476 · Cited by 45 · see citing works
Why Don't All Infants Have Bifidobacteria in Their Stool?
Tannock, G. W., Lee, P. S., Wong, K. H., & Lawley, B. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00834 · Cited by 44 · see citing works
Tobias, J. D., Olyaei, A. F., Laraway, B. J., Jordan, B. K., Dickinson, S., Golzarri‐Arroyo, L., Fialkowski, E., Owora, A. H., & Scottoline, B. P. (2022) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.12.070 · Cited by 43 · see citing works
Arboleya, S., Stanton, C., Ryan, C. A., Dempsey, E., & Ross, P. R. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033151 · Cited by 41 · see citing works
Kijner, S., Cher, A., & Yassour, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854122 · Cited by 42 · see citing works
Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum
Chaplin, A. V., Efimov, B. A., Smeianov, V. V., Кафарская, Л. И., Pikina, A. P., & Shkoporov, A. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135658 · Cited by 43 · see citing works
- Authors
- LoCascio, R. G., Desai, P., Sela, D. A., Weimer, B., & Mills, D. A.
- Affiliations
- University of California, Davis (US)
- Utah State University (US)
- Department of Viticulture and Enology, Robert Mondavi Center for Wine and Food Science
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2010-11-15
- Volume
- 76
- Issue
- 22
- Pages
- 7373-7381
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC2976205
- OpenAlex
- W2132366863
- Cited by
- 229
- References
- 59
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 25 · 2021: 17 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 11 · 2015: 18 · 2014: 14 · 2013: 8 · 2012: 13
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (2006-34526-17001)
- Dairy Management
- California Dairy Research Foundation
- National Institutes of Health
- Cooperative State Research, Education, and Extension Service
- National Institute of General Medical Sciences (T32GM008799, T32GM08799)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061923, R01HD059127)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Bifidobacterium longum subsp. infantis, Bifidobacterium longum subsp. longum, human milk oligosaccharides, comparative genomic hybridization, fucosidase, neuraminidase, glycoside hydrolases, ABC transporters, solute binding protein, infant gut colonization, breast-fed infants, gene clusters, multilocus sequence typing
- MeSH terms
- Bifidobacterium, DNA, Bacterial, Genes, Bacterial, Multigene Family, Genotype, Humans, Milk, Human, Molecular Sequence Data, Oligosaccharides, Phylogeny, Urea, Sequence Analysis, DNA, Metabolic Networks and Pathways, Comparative Genomic Hybridization, Multilocus Sequence Typing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review