The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation
Abstract
Activation of the transcription factor NF-κB after engagement of the T cell receptor (TCR) is important for T cell proliferation and activation during the adaptive immune response. Recent reports have elucidated a signaling pathway that involves the protein kinase C θ (PKCθ), the scaffold protein CARD11 (also called CARMA-1), the caspase recruitment domain (CARD)–containing protein Bcl10, and the paracaspase (protease related to caspases) MALT1 as critical intermediates linking the TCR to the IκB kinase (IKK) complex. However, the events proximal to the TCR that initiate the activation of this signaling pathway remain poorly defined. We demonstrate that 3-phosphoinositide-dependent kinase 1 (PDK1) has an essential role in this pathway by regulating the activation of PKCθ and through signal-dependent recruiting of both PKCθ and CARD11 to lipid rafts. PDK1-associated PKCθ recruits the IKK complex, whereas PDK1-associated CARD11 recruits the Bcl10-MALT1 complex, thereby allowing activation of the IKK complex through Bcl10-MALT1–dependent ubiquitination of the IKK complex subunit known as NEMO (NF-κB essential modifier). Hence, PDK1 plays a critical role by nucleating the TCR-induced NF-κB activation pathway in T cells.
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Cites
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Self-citationMissing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Self-citationCARMA1, BCL-10 and MALT1 in lymphocyte development and activation
Thome, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1352 · Cited by 391
Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells
Pfeifhofer, C., Kofler, K., Gruber, T., Ghaffari Tabrizi, N., Lutz, C., Maly, K., Leitges, M., & Baier, G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20020234 · Cited by 326
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Self-citationHayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178
Self-citationPerkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Hwang, J.-R., Byeon, Y., Kim, D., & Park, S.-G. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0435-8 · Cited by 470
An Enigmatic Tail of CD28 Signaling
Boomer, J. S., & Green, J. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002436 · Cited by 283
A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains
Düwel, M., Welteke, V., Oeckinghaus, A., Baens, M., Kloo, B., Ferch, U., Darnay, B. G., Ruland, J., Marynen, P., & Krappmann, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803313 · Cited by 233
Protein Kinase C-θ Promotes Th17 Differentiation via Upregulation of Stat3
Kwon, M.-J., Ma, J., Ding, Y., Wang, R., & Sun, Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102941 · Cited by 56
NFκB signaling in T cell memory
Daniels, M. A., Luera, D., & Teixeiro, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1129191 · Cited by 47
Faustmann, G., Meinitzer, A., Magnes, C., Tiran, B., Obermayer-Pietsch, B., Gruber, H.-J., Ribalta, J., Rock, E., Roob, J. M., & Winklhofer-Roob, B. M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0200489 · Cited by 16
Metadata
- Authors
- Lee, K.-Y., D'Acquisto, F., Hayden, M. S., Shim, J.-H., & Ghosh, S.
- Venue
- Science
- Published
- 2005-04
- Volume
- 308
- Issue
- 5718
- Pages
- 114-118
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999500196
- Cited by
- 253
- References
- 4
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- closed
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