Vertebrate-Type Intron-Rich Genes in the Marine Annelid Platynereis dumerilii
Abstract
Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human.
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P. dumerilii has emerged as a useful lophotrochozoan reference model that allows cross-comparisons with other bilaterians in aspects such as sensory, hormonal and developmental biology.
“P. dumerilii has emerged as a useful lophotrochozoan reference model that allows cross-comparisons with other bilaterians in aspects such as sensory, hormonal and developmental biology (71–74).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [72]
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- Authors
- Raible, F., Tessmar-Raible, K., Osoegawa, K., Wincker, P., Jubin, C., Balavoine, G., Ferrier, D., Benes, V., de Jong, P., Weissenbach, J., Bork, P., & Arendt, D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Developmental Unit, European Molecular Biological Laboratory (EMBL), Meyerhofstraße 1, D-69117 Heidelberg, Germany.
- Corresponding author
- Raible, Florian
- Arendt, Detlev
- ORCID
- Venue
- Science
- Published
- 2005-11-25
- Volume
- 310
- Issue
- 5752
- Pages
- 1325-1326
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2139431434
- Cited by
- 257
- References
- 16
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 19 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 7 · 2012: 11
- FWCI
- 37.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BBS/B/12067)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- intron gain and loss, Platynereis dumerilii, Polychaeta, bilaterian evolution, gene evolution, comparative genomics
- MeSH terms
- Animals, Bees, Ciona intestinalis, Exons, Genes, Humans, Introns, Molecular Sequence Data, Phylogeny, Polychaeta, Proteins, Species Specificity, Vertebrates, Sequence Alignment, Genome, Caenorhabditis elegans, Evolution, Molecular, Computational Biology
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