Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium.
Open accessAbstract
The evolution of the highest-order human brain center, the "pallium" or "cortex," remains enigmatic. To elucidate its origins, we set out to identify related brain parts in phylogenetically distant animals, to then unravel common aspects in cellular composition and molecular architecture. Here, we compare vertebrate pallium development to that of the mushroom bodies, sensory-associative brain centers, in an annelid. Using a newly developed protocol for cellular profiling by image registration (PrImR), we obtain a high-resolution gene expression map for the developing annelid brain. Comparison to the vertebrate pallium reveals that the annelid mushroom bodies develop from similar molecular coordinates within a conserved overall molecular brain topology and that their development involves conserved patterning mechanisms and produces conserved neuron types that existed already in the protostome-deuterostome ancestors. These data indicate deep homology of pallium and mushroom bodies and date back the origin of higher brain centers to prebilaterian times.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Similarly interacting brain centers, analogous or homologous to vertebrate regions, are present in invertebrate phyla such as arthropods and some annelids.
“Similarly interacting brain centers, analogous or homologous to these vertebrate regions, are present in invertebrate phyla such as arthropods and some annelids (for details see Tomer et al., 2010; Strausfeld and Hirth, 2013; Barron and Klein, 2016; Klein and Barron, 2016).”
From The Transition to Minimal Consciousness through the Evolution of Associative Learning (2016) · cites this paper as Tomer et al., 2010
Cites
Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617 · see citing works
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
The Universal Protein Resource (UniProt)
Bairoch, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki070 · Cited by 3,774 · see citing works
Henry, M. A. (1995) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1995.0108 · Cited by 3,454 · see citing works
Alignment by Maximization of Mutual Information
Viola, P. A., & Wells, W. M. (1997) · International Journal of Computer Vision · doi:10.1023/a:1007958904918 · Cited by 2,610 · see citing works
Violin Plots: A Box Plot-Density Trace Synergism
Hintze, J. L., & Nelson, R. D. (1998) · The American Statistician · doi:10.1080/00031305.1998.10480559 · Cited by 1,802 · see citing works
Mushroom body memoir: from maps to models
Heisenberg, M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1074 · Cited by 1,286 · see citing works
Alignment by maximization of mutual information
Viola, P. A., & Wells, W. M. (2002) · IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.1995.466930 · Cited by 1,080 · see citing works
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,050 · see citing works
Cerebral hemisphere regulation of motivated behavior
Swanson, L. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02905-x · Cited by 846 · see citing works
Longitudinal organization of the anterior neural plate and neural tube
Shimamura, K., Hartigan-O’Connor, D. J., Martı́nez, S., Puelles, L., & Rubenstein, J. L. R. (1995) · Development · doi:10.1242/dev.121.12.3923 · Cited by 657 · see citing works
Yoo, T. S., Ackerman, M., Lorensen, W. E., Schroeder, W., Chalana, V., Aylward, S., Metaxas, D., & Whitaker, R. (2002) · Studies in health technology and informatics · doi:10.3233/978-1-60750-929-5-586 · Cited by 621 · see citing works
Evolution, Discovery, and Interpretations of Arthropod Mushroom BodiesPreprint
Strausfeld, N. J., Hansen, L. K., Li, Y., Gomez, R. S., & Ito, K. (1998) · Learning & Memory · doi:10.1101/lm.5.1.11 · Cited by 580 · see citing works
Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.
Nieto, M., Schuurmans, C., Britz, O., & Guillemot, F. (2001) · Neuron · doi:10.1016/s0896-6273(01)00214-8 · Cited by 553 · see citing works
The evolution of cell types in animals: emerging principles from molecular studies
Arendt, D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2416 · Cited by 525 · see citing works
Self-citationMolecular taxonomy of major neuronal classes in the adult mouse forebrain
Sugino, K., Hempel, C. M., Miller, M. N., Hattox, A. M., Shapiro, P., Wu, C., Huang, Z. J., & Nelson, S. B. (2006) · Nature Neuroscience · doi:10.1038/nn1618 · Cited by 521 · see citing works
Denes, A. S., Jékely, G., Steinmetz, P. R. H., Raible, F., Snyman, H., Prud'homme, B., Ferrier, D. E. K., Balavoine, G., & Arendt, D. (2007) · Cell · doi:10.1016/j.cell.2007.02.040 · Cited by 480 · see citing works
Self-citationCiliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
Arendt, D., Tessmar-Raible, K., Snyman, H., Dorresteijn, A. W., & Wittbrodt, J. (2004) · Science · doi:10.1126/science.1099955 · Cited by 458 · see citing works
Self-citationGsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
Yun, K., Potter, S., & Rubenstein, J. L. R. (2001) · Development · doi:10.1242/dev.128.2.193 · Cited by 449 · see citing works
Violin Plots: A Box Plot-Density Trace Synergism
Hintze, J. L., & Nelson, R. D. (1998) · The American Statistician · doi:10.2307/2685478 · Cited by 429 · see citing works
Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., & Arendt, D. (2007) · Cell · doi:10.1016/j.cell.2007.04.041 · Cited by 384 · see citing works
Self-citationThe genetics of early telencephalon patterning: some assembly required
Hébert, J. M., & Fishell, G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2463 · Cited by 377 · see citing works
Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling
Houart, C., Caneparo, L., Heisenberg, C., Barth, K. A., Takeuchi, M., & Wilson, S. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00751-1 · Cited by 326 · see citing works
Ancient animal microRNAs and the evolution of tissue identity
Christodoulou, F., Raible, F., Tomer, R., Simakov, O., Trachana, K., Klaus, S., Snyman, H., Hannon, G. J., Bork, P., & Arendt, D. (2010) · Nature · doi:10.1038/nature08744 · Cited by 295 · see citing works
Self-citationDetection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
Deo, M., Yu, J., Chung, K.-H., Tippens, M., & Turner, D. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20847 · Cited by 283 · see citing works
Evolution of the bilaterian larval foregut
Arendt, D., Technau, U., & Wittbrodt, J. (2001) · Nature · doi:10.1038/35051075 · Cited by 272 · see citing works
Self-citationTranscriptional Regulation of Cortical Neuron Migration by POU Domain Factors
McEvilly, R. J., de Diaz, M. O., Schonemann, M. D., Hooshmand, F., & Rosenfeld, M. G. (2002) · Science · doi:10.1126/science.1067132 · Cited by 271 · see citing works
Role of Sox2 in the development of the mouse neocortex
Bani‐Yaghoub, M., Tremblay, R. G., Lei, J. X., Zhang, D., Zurakowski, B., Sandhu, J. K., Smith, B., Ribecco‐Lutkiewicz, M., Kennedy, J. A., Walker, P. R., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.007 · Cited by 271 · see citing works
Vertebrate-Type Intron-Rich Genes in the Marine Annelid <i>Platynereis dumerilii</i>
Raible, F., Tessmar-Raible, K., Osoegawa, K., Wincker, P., Jubin, C., Balavoine, G., Ferrier, D., Benes, V., de Jong, P., Weissenbach, J., et al. (2005) · Science · doi:10.1126/science.1119089 · Cited by 257 · see citing works
Self-citationFörster, E., Zhao, S., & Frotscher, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1882 · Cited by 243 · see citing works
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon.
Backman, M., Machoň, O., Mygland, L., van den Bout, C. J., Zhong, W., Taketo, M., & Krauss, S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.010 · Cited by 243 · see citing works
Keeble, T. R., Halford, M. M., Seaman, C., Kee, N., Macheda, M. L., Anderson, R. B., Stacker, S. A., & Cooper, H. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1175-06.2006 · Cited by 242 · see citing works
Ground plan of the insect mushroom body: Functional and evolutionary implications
Strausfeld, N. J., Sinakevitch, I. G., Brown, S. M., & Farris, S. M. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.21948 · Cited by 235 · see citing works
Molecular markers for identified neuroblasts in the developing brain ofDrosophila
Urbach, R., & Technau, G. M. (2003) · Development · doi:10.1242/dev.00533 · Cited by 224 · see citing works
Fate Mapping of the Mouse Prosencephalic Neural Plate
Inoue, T., Nakamura, S., & Osumi, N. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9616 · Cited by 201 · see citing works
Dorsoventral Patterning of the Telencephalon Is Disrupted in the Mouse Mutant extra-toesJ
Tole, S., Ragsdale, C. W., & Grove, E. A. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9509 · Cited by 196 · see citing works
Ebf1 controls early cell differentiation in the embryonic striatum
Garel, S., Marı́n, F., Grosschedl, R., & Charnay, P. (1999) · Development · doi:10.1242/dev.126.23.5285 · Cited by 193 · see citing works
Arendt, D., Tessmar, K., de Campos-Baptista, M.-I. M., Dorresteijn, A., & Wittbrodt, J. (2002) · Development · doi:10.1242/dev.129.5.1143 · Cited by 192 · see citing works
Self-citationMiura, H., Yanazawa, M., Kato, K., & Kitamura, K. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00062-2 · Cited by 179 · see citing works
Strausfeld, N. J., Strausfeld, C. M., Loesel, R., Rowell, D. M., & Stowe, S. (2006) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2006.3536 · Cited by 169 · see citing works
Integration of Telencephalic Wnt and Hedgehog Signaling Center Activities by Foxg1
Danesin, C., Peres, J., Johansson, M., Snowden, V., Cording, A., Papalopulu, N., & Houart, C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.03.007 · Cited by 164 · see citing works
Evolution of insect mushroom bodies: old clues, new insights
Farris, S. M. (2005) · Arthropod Structure & Development · doi:10.1016/j.asd.2005.01.008 · Cited by 146 · see citing works
Two visual systems in one brain: Neuropils serving the principal eyes of the spider Cupiennius salei
Strausfeld, N. J., Weltzien, P., & Barth, F. G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903280105 · Cited by 143 · see citing works
Fischer, A., & Dorresteijn, A. W. C. (2004) · BioEssays · doi:10.1002/bies.10409 · Cited by 141 · see citing works
Analysis of Cell Fate from Single-Cell Gene Expression Profiles in C. elegans
Liu, X., Long, F., Peng, H., Aerni, S. J., Jiang, M., Sánchez-Blanco, A., Murray, J. I., Preston, E. A., Mericle, B., Batzoglou, S., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.044 · Cited by 139 · see citing works
Essays on Growth and Form presented to D'Arcy Wentworth Thompson
Waddington, C. H. (1946) · Nature · doi:10.1038/157087a0 · Cited by 133 · see citing works
Early development of the Drosophila mushroom body: the roles of eyeless and dachshund
Noveen, A., Daniel, A., & Hartenstein, V. (2000) · Development · doi:10.1242/dev.127.16.3475 · Cited by 133 · see citing works
Schneider, S., & Bowerman, B. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.05.002 · Cited by 123 · see citing works
Stigloher, C., Ninkovic, J., Laplante, M. A., et al. (2006) · Development · doi:10.1242/dev.02450 · Cited by 121 · see citing works
Phylogenetic Analysis of the Wnt Gene Family
Prud’homme, B., Lartillot, N., Balavoine, G., Adoutte, A., & Vervoort, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01068-0 · Cited by 116 · see citing works
Two visual systems in one brain: Neuropils serving the secondary eyes of the spider Cupiennius salei
Strausfeld, N. J., & Barth, F. G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903280104 · Cited by 114 · see citing works
Hedgehog Signaling Regulates Segment Formation in the Annelid Platynereis
Dray, N., Tessmar‐Raible, K., Gouar, M. L., Vibert, L., Christodoulou, F., Schipany, K., Guillou, A., Zantke, J., Snyman, H., Béhague, J., et al. (2010) · Science · doi:10.1126/science.1188913 · Cited by 98 · see citing works
Self-citationTessmar‐Raible, K., Steinmetz, P. R. H., Snyman, H., Hassel, M., & Arendt, D. (2005) · BioTechniques · doi:10.2144/000112023 · Cited by 98 · see citing works
Self-citationKimura, J., Suda, Y., Kurokawa, D., Hossain, Z. M., Nakamura, M., Takahashi, M., Hara, A., & Aizawa, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0239-05.2005 · Cited by 95 · see citing works
Deuterostome brains: synopsis and commentary
Nieuwenhuys, R. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00668-2 · Cited by 93 · see citing works
Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1
Ekonomou, A., Kazanis, I., Malas, S., Wood, H. B., Alifragis, P., Denaxa, M., Karagogeos, D., Constanti, A., Lovell-Badge, R. H., & Episkopou, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030186 · Cited by 81 · see citing works
Jékely, G., & Arendt, D. (2007) · BioTechniques · doi:10.2144/000112462 · Cited by 80 · see citing works
Self-citationAscl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon
Wang, B., Waclaw, R. R., Allen, Z. J., Guillemot, F., & Campbell, K. (2009) · Neural Development · doi:10.1186/1749-8104-4-5 · Cited by 77 · see citing works
Essays on growth and form presented to D' Arcy Wentworth Thompson.
Clark, W. E. L. G., & Medawar, P. B. (1945) · Cited by 66 · see citing works
Simionato, E., Kerner, P., Dray, N., Gouar, M. L., Ledent, V., Arendt, D., & Vervoort, M. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-170 · Cited by 64 · see citing works
Self-citationKerner, P., Simionato, E., Gouar, M. L., & Vervoort, M. (2009) · Evolution & Development · doi:10.1111/j.1525-142x.2009.00359.x · Cited by 56 · see citing works
Compromised generation of GABAergic interneurons in the brains ofVax1-/- mice
Taglialatela, P., Soria, J. M., Caironi, V., Moiana, A., & Bertuzzi, S. (2004) · Development · doi:10.1242/dev.01299 · Cited by 54 · see citing works
Evolutionary Convergence of Higher Brain Centers Spanning the Protostome-Deuterostome Boundary
Farris, S. M. (2008) · Brain Behavior and Evolution · doi:10.1159/000151471 · Cited by 52 · see citing works
Arendt, D. (2005) · Theory in Biosciences · doi:10.1007/bf02814483 · Cited by 48 · see citing works
Self-citationEr81is a downstream target of Pax6 in cortical progenitors
Tuoc, T., & Stoykova, A. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-23 · Cited by 35 · see citing works
Rani, P., Stringa, E., Dharmavaram, R. M., Chatterjee, D., Tuan, R. S., & Khillan, J. S. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199901)214:1 · Cited by 20 · see citing works
Non-Associative Behavioural Modifications in Nereid Polychaetes
EVANS, S. M. (1966) · Nature · doi:10.1038/211945a0 · Cited by 15 · see citing works
Müller, W. A. (1973) · Cell and Tissue Research · doi:10.1007/bf02028390 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis
O'Connell, L. A., & Hofmann, H. A. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22735 · Cited by 986 · see citing works
High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin
Achim, K., Pettit, J.-B., Saraiva, L. R., Gavriouchkina, D., Larsson, T., Arendt, D., & Marioni, J. C. (2015) · Nature Biotechnology · doi:10.1038/nbt.3209 · Cited by 395 · see citing works
Self-citationFrom nerve net to nerve ring, nerve cord and brain — evolution of the nervous system
Arendt, D., Tosches, M. A., & Marlow, H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.15 · Cited by 279 · see citing works
Self-citationAncient deuterostome origins of vertebrate brain signalling centres
Pani, A. M., Mullarkey, E. E., Aronowicz, J., Assimacopoulos, S., Grove, E. A., & Lowe, C. J. (2012) · Nature · doi:10.1038/nature10838 · Cited by 252 · see citing works
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232 · see citing works
From chemotaxis to the cognitive map: The function of olfaction
Jacobs, L. F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201880109 · Cited by 227 · see citing works
Another place, another timer: marine species and the rhythms of life
Tessmar‐Raible, K., Raible, F., & Arboleda, E. (2011) · BioEssays · doi:10.1002/bies.201000096 · Cited by 208 · see citing works
Self-citationMemory-Relevant Mushroom Body Output Synapses Are Cholinergic
Barnstedt, O., Owald, D., Felsenberg, J., Brain, R., Moszynski, J.-P., Talbot, C. B., Perrat, P. N., & Waddell, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.015 · Cited by 197 · see citing works
Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates
Shigeno, S., Andrews, P. L. R., Ponte, G., & Fiorito, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00952 · Cited by 182 · see citing works
The neuropeptide complement of the marine annelid Platynereis dumerilii
Conzelmann, M., Williams, E. A., Krug, K., Franz-Wachtel, M., Macek, B., & Jékely, G. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-906 · Cited by 165 · see citing works
Conserved MIP receptor–ligand pair regulates <i>Platynereis</i> larval settlement
Conzelmann, M., Williams, E. A., Tunaru, S., Randel, N., Shahidi, R., Asadulina, A., Berger, J., Offermanns, S., & Jékely, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220285110 · Cited by 155 · see citing works
Circadian and circalunar clock interactions in a marine annelid
Zantke, J., Ishikawa-Fujiwara, T., Arboleda, E., Lohs, C., Schipany, K., Hallay, N., Straw, A. D., Todo, T., & Tessmar-Raible, K. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.031 · Cited by 148 · see citing works
Self-citationThe Transition to Minimal Consciousness through the Evolution of Associative Learning
Bronfman, Z. Z., Ginsburg, S., & Jablonka, E. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01954 · Cited by 133 · see citing works
“…we adopt here, is to start from a characterization of an evolutionary transition marker of minimal consciousness as a Frontiers in Psychology | www.frontiersin.org 2 December 2016 | Volume 7 | Article 1954 first step toward “reverse engineering” the (minimally conscious) system that enables it.”
BackgroundMethodBackfisch, B., Veedin Rajan, V. B., Fischer, R. M., Lohs, C., Arboleda, E., Tessmar-Raible, K., & Raible, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209657109 · Cited by 93 · see citing works
Self-citationDeSilva, J. M., Traniello, J. F. A., Claxton, A. G., & Fannin, L. D. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.742639 · Cited by 86 · see citing works
Verasztó, C., Jasek, S., Gühmann, M., Shahidi, R., Ueda, N., Beard, J. D., Mendes, S., Heinz, K., Bezares-Calderón, L. A., Williams, E., et al. (2020) · doi:10.1101/2020.08.21.260984 · Cited by 54 · see citing works
Wolff, G. H., & Strausfeld, N. J. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0055 · Cited by 61 · see citing works
Bannister, S., Antonova, O., Polo, A., Lohs, C., Hallay, N., Valinciute, A., Raible, F., & Tessmar-Raible, K. (2014) · Genetics · doi:10.1534/genetics.113.161091 · Cited by 56 · see citing works
“These have been facilitated by reliable techniques such as in situ hybridization (Tessmar-Raible et al. 2005), quantitative PCR (Dray et al. 2010; Zantke et al. 2013), and image registration (Tomer et al. 2010).”
MethodNeuropeptides control life-phase transitions
Schoofs, L., & Beets, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305724110 · Cited by 27 · see citing works
Evolutionary development of neural systems in vertebrates and beyond
O’Connell, L. A. (2013) · Journal of Neurogenetics · doi:10.3109/01677063.2013.789511 · Cited by 17 · see citing works
Conditional and specific cell ablation in the marine annelid Platynereis dumerilii
Veedin-Rajan, V. B., Fischer, R. M., Raible, F., & Tessmar-Raible, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075811 · Cited by 15 · see citing works
Self-citation
- Authors
- Tomer, R., Denes, A. S., Tessmar-Raible, K., & Arendt, D.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Tomer, Raju
- Arendt, Detlev
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 5
- Pages
- 800-809
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2014926287
- Cited by
- 317
- References
- 68
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 21 · 2023: 11 · 2022: 11 · 2021: 23 · 2020: 19 · 2019: 13 · 2018: 16 · 2017: 17 · 2016: 25 · 2015: 30 · 2014: 27 · 2013: 26 · 2012: 29
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Phaidra (Universität Wien) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- mushroom body, deep homology, brain development, gene expression profiling, image registration, neuronal cell types
- MeSH terms
- Animals, Cerebral Cortex, Biological Evolution, Humans, Polychaeta, Vertebrates, Body Patterning, Mushroom Bodies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review