Cited by 317Neurobiology and Insect Physiology ResearchDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium.

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Tomer, Raju, Denes, Alexandru S., Tessmar-Raible, Kristin, Arendt, Detlev·2010·Cell

Abstract

The evolution of the highest-order human brain center, the "pallium" or "cortex," remains enigmatic. To elucidate its origins, we set out to identify related brain parts in phylogenetically distant animals, to then unravel common aspects in cellular composition and molecular architecture. Here, we compare vertebrate pallium development to that of the mushroom bodies, sensory-associative brain centers, in an annelid. Using a newly developed protocol for cellular profiling by image registration (PrImR), we obtain a high-resolution gene expression map for the developing annelid brain. Comparison to the vertebrate pallium reveals that the annelid mushroom bodies develop from similar molecular coordinates within a conserved overall molecular brain topology and that their development involves conserved patterning mechanisms and produces conserved neuron types that existed already in the protostome-deuterostome ancestors. These data indicate deep homology of pallium and mushroom bodies and date back the origin of higher brain centers to prebilaterian times.

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Crossref · 10.1016/j.cell.2010.07.043

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  • Similarly interacting brain centers, analogous or homologous to vertebrate regions, are present in invertebrate phyla such as arthropods and some annelids.

    “Similarly interacting brain centers, analogous or homologous to these vertebrate regions, are present in invertebrate phyla such as arthropods and some annelids (for details see Tomer et al., 2010; Strausfeld and Hirth, 2013; Barron and Klein, 2016; Klein and Barron, 2016).”

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Authors
Tomer, R., Denes, A. S., Tessmar-Raible, K., & Arendt, D.
Affiliations
European Molecular Biology Laboratory (DE)
Corresponding author
  • Tomer, Raju
  • Arendt, Detlev
Venue
Cell
Publisher
Elsevier BV
Published
2010-09
Volume
142
Issue
5
Pages
800-809
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2014926287
Cited by
317
References
68
Citations by year
2026: 5 · 2025: 14 · 2024: 21 · 2023: 11 · 2022: 11 · 2021: 23 · 2020: 19 · 2019: 13 · 2018: 16 · 2017: 17 · 2016: 25 · 2015: 30 · 2014: 27 · 2013: 26 · 2012: 29
FWCI
10.98
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Phaidra (Universität Wien) (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
mushroom body, deep homology, brain development, gene expression profiling, image registration, neuronal cell types
MeSH terms
Animals, Cerebral Cortex, Biological Evolution, Humans, Polychaeta, Vertebrates, Body Patterning, Mushroom Bodies

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