Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms

In the citing paper

“They also mediate protection from venoms produced by a range of animals, including snakes and bees. 5 , 6 , 7”

In the citing paper

“On the other hand, mast cells can also be protective, for example against Staphylococcus, honeybee, and snake venom. 1 , 5 , 6 , 7”

In the citing paper

“Metz et al. showed that mast cells not only diminished the toxicity of sarafotoxin 6b and enhanced the survival of mice injected with that peptide, but also did so in mice injected with the whole venom of A. engaddensis [15].”

In the citing paper

“we will describe evidence that mast cells can enhance innate resistance, and survival, to challenge with reptile or arthropod venoms during a first exposure to such venoms.”

In the citing paper

“Using mast cell knock-in mice, Metz et al. also provided evidence that mast cells were important in substantially enhancing the innate resistance of mice to honeybee (Apis mellifera) venom and to the venoms of two North American pit vipers, the western diamondback rattlesnake (Crotalus atrox) and the southern copperhead (Agkistrodon contortrix contortrix) [15].”

In the citing paper

“However, later work by our group, employing both pharmacological approaches and shRNA knock down of CPA3 in adoptively-transferred mast cells [15], as well as elegant studies by Schneider et al., who exploited a mouse they created which expressed only a catalytically inactive CPA3 [81], indicated that CPA3 is the key mast cell-derived protease that detoxifies both ET-1 and sarafotoxin 6b.”

In the citing paper

“The latter finding suggested that mast cells can contribute to IgE-mediated acquired resistance to honeybee venom, as well as enhance the innate resistance of mice to a first exposure to that venom [15].”