Cited by 106Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Nonoscillatory Phase Coding and Synchronization in the Bat Hippocampal Formation

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Eliav, Tamir, Geva-Sagiv, Maya, Yartsev, Michael M., Finkelstein, Arseny, Rubin, Alon, Las, Liora, Ulanovsky, Nachum·2018·Cell

Abstract

Hippocampal theta oscillations were proposed to be important for multiple functions, including memory and temporal coding of position. However, previous findings from bats have questioned these proposals by reporting absence of theta rhythmicity in bat hippocampal formation. Does this mean that temporal coding is unique to rodent hippocampus and does not generalize to other species? Here, we report that, surprisingly, bat hippocampal neurons do exhibit temporal coding similar to rodents, albeit without any continuous oscillations at the 1-20 Hz range. Bat neurons exhibited very strong locking to the non-rhythmic fluctuations of the field potential, such that neurons were synchronized together despite the absence of oscillations. Further, some neurons exhibited "phase precession" and phase coding of the bat's position-with spike phases shifting earlier as the animal moved through the place field. This demonstrates an unexpected type of neural coding in the mammalian brain-nonoscillatory phase coding-and highlights the importance of synchrony and temporal coding for hippocampal function across species.

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Crossref · 10.1016/j.cell.2018.09.017

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  • Unlike during locomotion, theta oscillations during immobility occurred in short bouts, resembling oscillatory dynamics described in the human and bat hippocampus.

    “Unlike during locomotion, where theta oscillations are a prominent and steady rhythm, theta oscillations during immobility occurred in short bouts (Fig. 2a and Supplementary Fig. 4), thus resembling the oscillatory dynamics described in other species (e.g., in the human98 and bat hippocampus99).”

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Authors
Eliav, T., Geva-Sagiv, M., Yartsev, M. M., Finkelstein, A., Rubin, A., Las, L., & Ulanovsky, N.
Affiliations
Weizmann Institute of Science (IL)
Corresponding author
Ulanovsky, Nachum
Venue
Cell
Publisher
Elsevier BV
Published
2018-11
Volume
175
Issue
4
Pages
1119-1130.e15
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2896052853
Cited by
106
References
55
Citations by year
2026: 6 · 2025: 14 · 2024: 16 · 2023: 17 · 2022: 14 · 2021: 15 · 2020: 10 · 2019: 12 · 2018: 2
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Research Council (ERC-StG-NEUROBAT, ERC-CoG-NATURAL_BAT_NAV)
  • Human Frontiers Science Program (RGP0062/2009-C)
  • Israel Science Foundation (ISF 1017/08, ISF 1319/13)
  • Minerva Foundation (André Deloro Prize for Scientific Research)
  • Adelis Foundation
  • Clore
  • Lev-Zion
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hippocampal theta oscillations, phase precession, neuronal synchronization, temporal coding, spatial coding, place fields, field potentials, hippocampal formation, cross-species comparison
MeSH terms
Animals, Chiroptera, Cortical Synchronization, Biological Evolution, Hippocampus, Interneurons, Male, Theta Rhythm, Rats

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