The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Abstract
Chromosomal rearrangements that create gene fusions are common features of human tumors. The prevailing view is that the resultant chimeric transcripts and proteins are abnormal, tumor-specific products that provide tumor cells with a growth and/or survival advantage. We show that normal endometrial stromal cells contain a specific chimeric RNA joining 5′ exons of the JAZF1 gene on chromosome 7p15 to 3′ exons of the Polycomb group gene JJAZ1/SUZ12 on chromosome 17q11 and that this RNA is translated into JAZF1-JJAZ1, a protein with anti-apoptotic activity. The JAZF1-JJAZ1 RNA appears to arise from physiologically regulated trans-splicing between precursor messenger RNAs for JAZF1 and JJAZ1 . The chimeric RNA and protein are identical to those produced from a gene fusion found in human endometrial stromal tumors. These observations suggest that certain gene fusions may be pro-neoplastic owing to constitutive expression of chimeric gene products normally generated by trans-splicing of RNAs in developing tissues.
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Cites
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
Tomlins, S. A., Rhodes, D. R., Perner, S., Dhanasekaran, S. M., Mehra, R., Sun, X.-W., Varambally, S., Cao, X., Tchinda, J., Kuefer, R., et al. (2005) · Science · doi:10.1126/science.1117679 · Cited by 3,846
The impact of translocations and gene fusions on cancer causation
Mitelman, F., Johansson, B., & Mertens, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2091 · Cited by 1,400
Oncogenic Transcription Factors in the Human Acute Leukemias
Look, A. T. (1997) · Science · doi:10.1126/science.278.5340.1059 · Cited by 1,187
Alternative pre-mRNA splicing and proteome expansion in metazoans
Maniatis, T., & Tasic, B. (2002) · Nature · doi:10.1038/418236a · Cited by 768
A trans-spliced leader sequence on actin mRNA in C. elegans
Krause, M., & Hirsh, D. (1987) · Cell · doi:10.1016/0092-8674(87)90613-1 · Cited by 639
Evidence for Trans splicing in trypanosomes
Sutton, R. E., & Boothroyd, J. C. (1986) · Cell · doi:10.1016/0092-8674(86)90617-3 · Cited by 486
Reversibility of acute B-cell leukaemia induced by BCR–ABL1
Huettner, C. S., Zhang, P., Van Etten, R. A., & Tenen, D. G. (2000) · Nature Genetics · doi:10.1038/71691 · Cited by 413
Pardanani, A., Ketterling, R. P., Brockman, S. R., Flynn, H. C., Paternoster, S. F., Shearer, B. M., Reeder, T. L., Li, C.-Y., Cross, N. C. P., Cools, J., et al. (2003) · Blood · doi:10.1182/blood-2003-05-1627 · Cited by 393
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors
Koontz, J. I., Soreng, A. L., Nucci, M., Kuo, F. C., Pauwels, P., van den Berghe, H., Cin, P. D., Fletcher, J. A., & Sklar, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101132598 · Cited by 390
Self-citationTrans splicing of nuclear pre-mRNAs
Agabian, N. (1990) · Cell · doi:10.1016/0092-8674(90)90674-4 · Cited by 386
Cited by
RNA sequencing: advances, challenges and opportunities
Ozsolak, F., & Milos, P. M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2934 · Cited by 2,135
“Furthermore, genomic DNA-based approaches cannot identify fusion events that are due to non-genomic factors, such as trans -splicin”
BackgroundIntegrative analysis of the melanoma transcriptome
Berger, M. F., Levin, J. Z., Vijayendran, K., Sivachenko, A., Adiconis, X., Maguire, J., Johnson, L. A., Robinson, J., Verhaak, R. G., Sougnez, C., et al. (2010) · Genome Research · doi:10.1101/gr.103697.109 · Cited by 305
Lessons from non-canonical splicing
Sibley, C. R., Blazquez, L., & Ule, J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.46 · Cited by 316
From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond
Michelini, F., Jalihal, A. P., Francia, S., Meers, C., Neeb, Z. T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00487 · Cited by 85
Yotova, I., Hsu, E., Do, C., Gaba, A., Sczabolcs, M., Dekan, S., Kenner, L., Wenzl, R., & Tycko, B. (2017) · PLOS ONE · doi:10.1371/journal.pone.0170859 · Cited by 81
Metadata
- Authors
- Li, H., Wang, J., Mor, G., & Sklar, J.
- Venue
- Science
- Published
- 2008-09-05
- Volume
- 321
- Issue
- 5894
- Pages
- 1357-1361
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027963144
- Cited by
- 310
- References
- 21
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
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