Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs
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In the vertebrate neural tube, a morphogen-induced transcriptional network produces multiple molecularly distinct progenitor domains, each generating different neuronal subtypes. Using an in vitro differentiation system, we defined gene expression signatures of distinct progenitor populations and identified direct gene-regulatory inputs corresponding to locations of specific transcription factor binding. Combined with targeted perturbations of the network, this revealed a mechanism in which a progenitor identity is installed by active repression of the entire transcriptional programs of other neural progenitor fates. In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly expressed transcriptional activators, concurrently activates the gene expression programs of several domains. The specific outcome is selected by repressive input provided by Shh-induced transcription factors that act as the key nodes in the network, enabling progenitors to adopt a single definitive identity from several initially permitted options. Together, the data suggest design principles relevant to many developing tissues.
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These TFs form a gene regulatory network that establishes progenitor identities by repressing not only adjacent progenitor identities but also a wide range of alternative fates.
“These TFs form a gene regulatory network that establishes progenitor identities by repressing not only adjacent progenitor identities but also a wide range of alternative fates (Kutejova et al., 2016; Nishi et al., 2015).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Kutejova et al., 2016
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- Authors
- Kutejova, E., Sasai, N., Shah, A., Gouti, M., & Briscoe, J.
- Affiliations
- National Institute for Medical Research (GB)
- Corresponding author
- Briscoe, James
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 36
- Issue
- 6
- Pages
- 639-653
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC4819439
- OpenAlex
- W2296594992
- Cited by
- 87
- References
- 73
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 5
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Developmental Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- NAIST Digital Library (Nara Institute of Science and Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- MRC (U117560541)
- Wellcome Trust (WT098326MA)
- EMBO
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- transcriptional repression, neural tube, Sonic hedgehog signaling, transcription factor binding, neuronal subtype specification, progenitor cell differentiation, gene regulatory networks, transcriptional activator, ventral neural tube
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Homeobox Protein Nkx-2.2, Animals, Cell Differentiation, Cell Line, Chick Embryo, Nerve Tissue Proteins, Transcription Factors, Transcription, Genetic, Signal Transduction, Homeodomain Proteins, Gene Expression Regulation, Developmental, Cell Lineage, Body Patterning, Zebrafish Proteins, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Neural Stem Cells
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