Cited by 1,748Hydrogels: synthesis, properties, applicationsPhotopolymerization techniques and applications3D Printing in Biomedical Research

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

Open access

Kloxin, April M., Kasko, Andrea M., Salinas, Chelsea N., Anseth, Kristi S.·2009·Science

DOI 10.1126/science.1169494PMC PMC2756032

Open this paper in CoChat — free account

Abstract

We report a strategy to create photodegradable poly(ethylene glycol)–based hydrogels through rapid polymerization of cytocompatible macromers for remote manipulation of gel properties in situ. Postgelation control of the gel properties was demonstrated to introduce temporal changes, creation of arbitrarily shaped features, and on-demand pendant functionality release. Channels photodegraded within a hydrogel containing encapsulated cells allow cell migration. Temporal variation of the biochemical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells. Photodegradable gels that allow real-time manipulation of material properties or chemistry provide dynamic environments with the scope to answer fundamental questions about material regulation of live cell function and may affect an array of applications from design of drug delivery vehicles to tissue engineering systems.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1169494

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E. I., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,875
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Silva, G. A., Czeisler, C. M., Niece, K. L., Beniash, E., Harrington, D. A., Kessler, J. A., & Stupp, S. I. (2004) · Science · doi:10.1126/science.1093783 · Cited by 2,179
Introduction to Polymers
Young, R. J., & Lovell, P. A. (1981) · CRC Press eBooks · doi:10.1007/978-1-4615-3478-5 · Cited by 2,152
Myotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Advances in biomaterials, drug delivery, and bionanotechnology
Langer, R., & Peppas, N. A. (2003) · AIChE Journal · doi:10.1002/aic.690491202 · Cited by 982
Microengineered hydrogels for tissue engineering
Khademhosseini, A., & Langer, R. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.021 · Cited by 830
Microfabrication meets microbiology
Weibel, D. B., DiLuzio, W. R., & Whitesides, G. M. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1616 · Cited by 806

Flagged first, then by citations

Show all 34 references

Research works printed but not linked: 2

10.1021/bm060086 · DOI
S. J. Bryant, K. S. Anseth, in Scaffolding in Tissue Engineering, P. X. Ma, J. Elisseeff, Eds. (Marcel Dekker, New York, 2005), pp. 69–88.

Sorted by citations

Items 801–900 of 1,001

Photo-responsive photonic hydrogel: in situ manipulation and monitoring of cell scaffold stiffness
Li, S., Zeng, Y., Hou, W., Wan, W., Zhang, J., Wang, Y., Du, X. Z., & Gu, Z. (2020) · Materials Horizons · doi:10.1039/d0mh01019g · Cited by 42
Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds
Naga, N., Sato, M., Mori, K., Nageh, H., & Nakano, T. (2020) · Polymers · doi:10.3390/polym12092047 · Cited by 42
Recent advances in chemically defined and tunable hydrogel platforms for organoid culture
Agarwal, T., Celikkin, N., Costantini, M., Maiti, T. K., & Makvandi, P. (2021) · Bio-Design and Manufacturing · doi:10.1007/s42242-021-00126-7 · Cited by 44
Mechanotransduction assays for neural regeneration strategies: A focus on glial cells
Marinval, N., & Chew, S. Y. (2021) · APL Bioengineering · doi:10.1063/5.0037814 · Cited by 42
In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies
Rahmanian, M., Seyfoori, A., Ghasemi, M., Shamsi, M., Kolahchi, A. R., Modarres, H. P., Sanati‐Nezhad, A., & Majidzadeh‐A, K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.024 · Cited by 42
Biomedical Applications of Photochemistry
Chan, B. P. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0797 · Cited by 42
Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling
Walker, C. J., Batan, D., Bishop, C. T., Ramirez, D., Aguado, B. A., Schroeder, M. E., Crocini, C., Schwisow, J. A., Moulton, K. S., Macdougall, L. J., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10394 · Cited by 39
Self-citation
3D multicellular systems in disease modelling: From organoids to organ-on-chip
Goldrick, C., Guri, I., Herrera-Oropeza, G. E., O’Brien-Gore, C., Roy, E., Wojtynska, M., & Spagnoli, F. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1083175 · Cited by 44
PEG-Poly(l-alanine) Thermogel As a 3D Scaffold of Bone-Marrow-Derived Mesenchymal Stem Cells
Park, M. H., Moon, H. J., Park, J. H., Shinde, U. P., Ko, D. Y., & Jeong, B. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201400426 · Cited by 41
Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos
Peng, K., Cui, C., Tomatsu, I., Porta, F., Meijer, A. H., Spaink, H. P., & Kros, A. (2010) · Soft Matter · doi:10.1039/c0sm00096e · Cited by 41
Cell-compatible hydrogels based on a multifunctional crosslinker with tunable stiffness for tissue engineering
Shi, J., Ouyang, J., Li, Q., Wang, L., Wu, J., Zhong, W., & Xing, M. M. Q. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm34862d · Cited by 42
Optimization of a polydopamine (PD)-based coating method and polydimethylsiloxane (PDMS) substrates for improved mouse embryonic stem cell (ESC) pluripotency maintenance and cardiac differentiation
Fu, J., Chuah, Y. J., Ang, W. T., Zheng, N., & Wang, D. (2017) · Biomaterials Science · doi:10.1039/c7bm00266a · Cited by 41
Biofabrication strategies for creating microvascular complexity
Clyne, A. M., Swaminathan, S., & Lantada, A. D. (2019) · Biofabrication · doi:10.1088/1758-5090/ab0621 · Cited by 43
Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering
Silva, T. P., Cotovio, J. P., Bekman, E., Carmo‐Fonseca, M., Cabral, J. M. S., & Fernandes, T. G. (2019) · Stem Cells International · doi:10.1155/2019/4508470 · Cited by 42
Three-dimensional encapsulation of adult mouse cardiomyocytes in hydrogels with tunable stiffness
Crocini, C., Walker, C. J., Anseth, K. S., & Leinwand, L. A. (2019) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.04.008 · Cited by 43
Self-citation
Hybrid Microgels with Thermo‐Tunable Elasticity for Controllable Cell Confinement
Hackelbusch, S., Rossow, T., Steinhilber, D., Weitz, D. A., & Seiffert, S. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500359 · Cited by 41
Facile preparation of photodegradable hydrogels by photopolymerization
Ki, C. S., Shih, H., & Lin, C. (2013) · Polymer · doi:10.1016/j.polymer.2013.02.018 · Cited by 41
Directing cell migration in continuous microchannels by topographical amplification of natural directional persistence
Ko, Y., Co, C. C., & Ho, C. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.071 · Cited by 41
Regulating synthetic gene networks in 3D materials
Deans, T. L., Singh, A., Gibson, M. A., & Elisseeff, J. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204705109 · Cited by 40
Regulation of Breast Cancer Progression by Extracellular Matrix Mechanics: Insights from 3D Culture Models
Lee, J. Y., & Chaudhuri, O. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00071 · Cited by 39
Graphene oxide reinforced hydrogels for osteogenic differentiation of human adipose-derived stem cells
Noh, M., Kim, S., Kim, J., Lee, J., Jeong, G., Yoon, J., Kang, S., Bhang, S. H., Yoon, H. H., Lee, J., et al. (2017) · RSC Advances · doi:10.1039/c7ra02410j · Cited by 40
Reproducible Dendronized PEG Hydrogels via SPAAC Cross-Linking
Hodgson, S. M., McNelles, S. A., Abdullahu, L., Marozas, I. A., Anseth, K. S., & Adronov, A. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01115 · Cited by 42
Self-citation
Photo‐controlled Growth of Telechelic Polymers and End‐linked Polymer Gels
Zhou, H., & Johnson, J. A. (2013) · Angewandte Chemie · doi:10.1002/ange.201207966 · Cited by 41
Activated‐Ester‐Type Photocleavable Crosslinker for Preparation of Photodegradable Hydrogels Using a Two‐Component Mixing Reaction
Yanagawa, F., Sugiura, S., Takagi, T., Sumaru, K., Camci‐Unal, G., Patel, A. C., Khademhosseini, A., & Kanamori, T. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400180 · Cited by 39
Photocleavable coumarin crosslinkers based polystyrene microgels: phototriggered swelling and release
Huang, Q., Bao, C., Ji, W., Wang, Q., & Zhu, L. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm33789d · Cited by 39
Responsive Nanogel Probe for Ratiometric Fluorescent Sensing of pH and Strain in Hydrogels
Zhu, M., Lu, D., Wu, S., Lian, Q., Wang, W., Milani, A. H., Cui, Z., Nguyen, N. T., Mu, C., Lyon, L. A., et al. (2017) · ACS Macro Letters · doi:10.1021/acsmacrolett.7b00709 · Cited by 39
Thermal Stabilization of Biologics with Photoresponsive Hydrogels
Sridhar, B. V., Janczy, J. R., Hatlevik, Ø., Wolfson, G., Anseth, K. S., & Tibbitt, M. W. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.7b01507 · Cited by 39
Self-citation
Red and Near‐Infrared Light‐Cleavable Polymers
Zeng, X., Zhou, X., & Wu, S. (2018) · Macromolecular Rapid Communications · doi:10.1002/marc.201800034 · Cited by 39
Hydrogen-Bonding-Driven Tough Ionogels Containing Spiropyran-Functionalized Ionic Liquids
Cao, Z., Liu, H., & Jiang, L. (2020) · ACS Applied Polymer Materials · doi:10.1021/acsapm.0c00297 · Cited by 39
Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation
Shahi, S., Roghani‐Mamaqani, H., Talebi, S., & Mardani, H. (2021) · Polymer Chemistry · doi:10.1039/d1py01066b · Cited by 39
Myoblast mechanotransduction and myotube morphology is dependent on BAG3 regulation of YAP and TAZ
Günay, K. A., Silver, J. S., Chang, T.-L., Bednarski, O. J., Bannister, K. L., Rogowski, C. J., Olwin, B. B., & Anseth, K. S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121097 · Cited by 42
Self-citation
DNA Hydrogels as Functional Materials and Their Biomedical Applications
Ma, Y., Duan, X., & Huang, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202309070 · Cited by 42
Tunable Bicontinuous Macroporous Cell Culture Scaffolds via Kinetically Controlled Phase Separation
Dudaryeva, O. Y., Cousin, L., Krajnovic, L., Gröbli, G., Sapkota, V., Ritter, L., Deshmukh, D., Cui, Y., Style, R. W., Levato, R., et al. (2025) · Advanced Materials · doi:10.1002/adma.202410452 · Cited by 40
Increased matrix synthesis by fibroblasts with decreased proliferation on synthetic chitosan–gelatin porous structures
Iyer, P., Walker, K. J., & Madihally, S. V. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.24396 · Cited by 38
New Applications of Photolabile Nitrobenzyl Groups in Polymers
Thomas, S. W. (2012) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201200486 · Cited by 38
Nanometric Micelles with Photo‐Triggered Cytotoxicity
Anilkumar, P., Gravel, E., Théodorou, I., Gombert, K., Thezé, B., Ducongè, F., & Doris, E. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201400840 · Cited by 38
A Gene Therapy Technology‐Based Biomaterial for the Trigger‐Inducible Release of Biopharmaceuticals in Mice
Kämpf, M. M., Christen, E. H., Ehrbar, M., Baba, M. D., Hamri, G. C., Fussenegger, M., & Weber, W. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200902377 · Cited by 37
Thermal gelling polyalanine-poloxamine-polyalanine aqueous solution for chondrocytes 3D culture: Initial concentration effect
Choi, B. G., Park, M. H., Cho, S., Joo, M. K., Oh, H. J., Kim, E. H., Park, K., Han, D. K., & Jeong, B. (2010) · Soft Matter · doi:10.1039/c0sm00611d · Cited by 38
A Versatile Approach to Engineering Biomolecule‐Presenting Cellular Microenvironments
Lienemann, P. S., Karlsson, M., Sala, A., Wischhusen, H. M., Weber, F. E., Zimmermann, R., Weber, W., Lütolf, M. P., & Ehrbar, M. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200280 · Cited by 41
Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses
Murphy, N. P., & Lampe, K. J. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01045d · Cited by 38
Core–shell patterning of synthetic hydrogels via interfacial bioorthogonal chemistry for spatial control of stem cell behavior
Dicker, K. T., Song, J., Moore, A. C., Zhang, H., Li, Y., Burris, D. L., Jia, X., & Fox, J. M. (2018) · Chemical Science · doi:10.1039/c8sc00495a · Cited by 38
In vivo response to dynamic hyaluronic acid hydrogels
Young, J. L., Tuler, J., Braden, R. L., Schup-Magoffin, P. J., Schaefer, J., Kretchmer, K., Christman, K. L., & Engler, A. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.019 · Cited by 38
Extracellular Matrix‐Mimetic Immunomodulatory Hydrogel for Accelerating Wound Healing
Wang, H., Huang, R., Bai, L., Cai, Y., Miao, L., Bao, C., Lin, S., Ji, S., Liu, C., & Qu, X. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301264 · Cited by 39
3D Nanoprinting Technologies for Tissue Engineering Applications
Lee, J. W. (2015) · Journal of Nanomaterials · doi:10.1155/2015/213521 · Cited by 37
Hierarchical Assembly of Bioactive Amphiphilic Molecule Pairs into Supramolecular Nanofibril Self-Supportive Scaffolds for Stem Cell Differentiation
Wang, Z., Zhang, F., Wang, Z., Liu, Y., Fu, X., Jin, A. J., Yung, B. C., Chen, W., Fan, J., Yang, X., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b09014 · Cited by 36
Engineering a Cell Home for Stem Cell Homing and Accommodation
Wu, R., Yin, Y., He, X., Li, X., & Chen, F. (2017) · Advanced Biosystems · doi:10.1002/adbi.201700004 · Cited by 37
Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential
Kharkar, P. M., Scott, R. A., Olney, L. P., LeValley, P. J., Maverakis, E. M., Kiick, K. L., & Kloxin, A. M. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700713 · Cited by 37
Self-citation
Coatings on mammalian cells: interfacing cells with their environment
Davis, K. A., Wu, P.-J., Cahall, C. F., Li, C., Gottipati, A., & Berron, B. J. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-018-0131-6 · Cited by 37
Breaking with Light: Stimuli-Responsive Mesoporous Organosilica Particles
Picchetti, P., DiMarco, B. N., Travaglini, L., Zhang, Y., Ortega-Liebana, M. C., & Cola, L. D. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b03937 · Cited by 37
Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review
Roy, S., Cha, J. N., & Goodwin, A. P. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00529 · Cited by 37
Advances in Extracellular Matrix-Mimetic Hydrogels to Guide Stem Cell Fate
Stowers, R. S. (2021) · Cells Tissues Organs · doi:10.1159/000514851 · Cited by 37
Rational Design of Hydrogel Networks with Dynamic Mechanical Properties to Mimic Matrix Remodeling
Wiley, K. L., Sutherland, B. P., Ogunnaike, B. A., & Kloxin, A. M. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101947 · Cited by 36
Self-citation
Hydrolytically Degradable Microgels with Tunable Mechanical Properties Modulate the Host Immune Response
Coronel, M. M., Martin, K. E., Hunckler, M. D., Kalelkar, P. P., Shah, R. M., & Garcı́a, A. J. (2022) · Small · doi:10.1002/smll.202106896 · Cited by 38
Modular Degradable Hydrogels Based on Thiol-Reactive Oxanorbornadiene Linkers
Higginson, C. J., Kim, S. Y., Peláez-Fernández, M., Fernández‐Nieves, A., & Finn, M. G. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b02708 · Cited by 37
Light-Triggered Cross-Linking of Alginates with Caged Ca2+
Cui, J., Wang, M., Zheng, Y., Rodríguez‐Muñiz, G. M., & del Campo, A. (2013) · Biomacromolecules · doi:10.1021/bm400022h · Cited by 37
Photocleavable side groups to spatially alter hydrogel properties and cellular interactions
Ramanan, V., Katz, J. S., Güvendiren, M., Cohen, E. R., Marklein, R. A., & Burdick, J. A. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00734j · Cited by 37
UV-triggered thiol–disulfide exchange reaction towards tailored biodegradable hydrogels
Wang, L., Li, L., Wang, X., Huang, D., Yang, F., Shen, H. Y., Li, Z., & Wu, D. (2016) · Polymer Chemistry · doi:10.1039/c5py01925g · Cited by 37
Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment
Huang, J., Wang, L., Xiong, C., & Yuan, F. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.024 · Cited by 36
Material control of stem cell differentiation: challenges in nano-characterization
Dingal, P. C. D. P., & Discher, D. E. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.11.003 · Cited by 36
Hydrogels mimicking the viscoelasticity of extracellular matrix for regenerative medicine: Design, application, and molecular mechanism
Li, L., Wang, S., Chen, Y., Dong, S., Zhang, C., Liao, L., & Zhang, W. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155206 · Cited by 40
Conditional DNA‐Protein Interactions Confer Stimulus‐Sensing Properties to Biohybrid Materials
Christen, E. H., Karlsson, M., Kämpf, M. M., Schoenmakers, R. G., Gübeli, R. J., Wischhusen, H. M., Friedrich, C., Fussenegger, M., & Weber, W. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201100731 · Cited by 36
Synthetic hydrogels with stiffness gradients for durotaxis study and tissue engineering scaffolds
Whang, M., & Kim, J. (2016) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-016-0026-x · Cited by 35
Injectable biomaterials for stem cell delivery and tissue regeneration
Zhang, Z. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2017.1256389 · Cited by 36
Printed Soft Optical Waveguides of PLA Copolymers for Guiding Light into Tissue
Feng, J., Jiang, Q., Rogin, P., de Oliveira, P. W., & del Campo, A. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c03903 · Cited by 38
Hyaluronic acid-based hydrogels with tobacco mosaic virus containing cell adhesive peptide induce bone repair in normal and osteoporotic rats.
Yuan, J., Maturavongsadit, P., Zhou, Z., Lv, B., Lin, Y., Yang, J. R., & Luckanagul, J. A. (2020) · PubMed Central · doi:10.3877/cma.j.issn.2096-112x.2020.01.009 · Cited by 36
pH-responsive physical gels from poly(meth)acrylic acid-containing crosslinked particles: the relationship between structure and mechanical properties
Halacheva, S. S., Freemont, A. J., & Saunders, B. R. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20758g · Cited by 36
Harnessing isomerization-mediated manipulation of nonspecific cell/matrix interactions to reversibly trigger and suspend stem cell differentiation
Bai, T., Sinclair, A., Sun, F., Jain, P. R., Hung, H., Zhang, P., Ella‐Menye, J., Liu, W., & Jiang, S. (2015) · Chemical Science · doi:10.1039/c5sc03244j · Cited by 35
Dynamic cell-adhesive microenvironments and their effect on myogenic differentiation
Weis, S., Lee, T. T., del Campo, A., & Garcı́a, A. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.019 · Cited by 35
BMSCs laden injectable amino-diethoxypropane modified alginate-chitosan hydrogel for hyaline cartilage reconstruction
Wan, W., Li, Q., Gao, H., Ge, L., Liu, Y., Zhong, W., Ouyang, J., & Xing, M. M. Q. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01394h · Cited by 35
Photolysis of a bola-type supra-amphiphile promoted by water-soluble pillar[5]arene-induced assembly
Guo, S., Liu, X., Yao, C., Lu, C., Chen, Q., Hu, X., & Wang, L. (2016) · Chemical Communications · doi:10.1039/c6cc05993g · Cited by 35
Dynamic Mechanical Control of Alginate-Fibronectin Hydrogels with Dual Crosslinking: Covalent and Ionic
Trujillo, S., Seow, M., Lueckgen, A., Salmeron-Sanchez, M., & Cipitria, A. (2021) · Polymers · doi:10.3390/polym13030433 · Cited by 35
Direct evidence of gel–sol transition in cyclodextrin-based hydrogels as revealed by FTIR-ATR spectroscopy
Crupi, V., Majolino, D., Mele, A., Melone, L., Punta, C., Rossi, B., Toraldo, F., Trotta, F., & Venuti, V. (2014) · Soft Matter · doi:10.1039/c3sm52354c · Cited by 35
Smart hydrogels with high tunability of stiffness as a biomimetic cell carrier
Zhao, H., Xu, K., Zhu, P., Wang, C., & Chi, Q. (2018) · Cell Biology International · doi:10.1002/cbin.11091 · Cited by 35
Photoresponsive Chemistries for User-Directed Hydrogel Network Modulation to Investigate Cell–Matrix Interactions
Ohnsorg, M. L., Hushka, E. A., & Anseth, K. S. (2024) · Accounts of Chemical Research · doi:10.1021/acs.accounts.4c00548 · Cited by 34
Self-citation
Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective
DelNero, P. F., Song, Y. H., & Fischbach, C. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9763-y · Cited by 35
Crosslinked PEG mats for peptide immobilization and stem cell adhesion
Schmitt, S. K., Murphy, W. L., & Gopalan, P. (2013) · Journal of Materials Chemistry B · doi:10.1039/c2tb00253a · Cited by 34
Photoresponsive hydrogel networks using melanin nanoparticle photothermal sensitizers
Ninh, C., Cramer, M. C., & Bettinger, C. J. (2014) · Biomaterials Science · doi:10.1039/c3bm60321k · Cited by 34
About Chemical Strategies to Fabricate Cell‐Instructive Biointerfaces with Static and Dynamic Complexity
Koçer, G., & Jonkheijm, P. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701192 · Cited by 34
Immunofunctional photodegradable poly(ethylene glycol) hydrogel surfaces for the capture and release of rare cells
LeValley, P. J., Tibbitt, M. W., Noren, B. E., Kharkar, P. M., Kloxin, A. M., Anseth, K. S., Toner, M., & Oakey, J. S. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.049 · Cited by 36
Self-citation
Photon Upconversion Hydrogels for 3D Optogenetics
Meir, R., Hirschhorn, T., Kim, S., Fallon, K. J., Churchill, E. M., Wu, D., Yang, H. W., Stockwell, B. R., & Campos, L. M. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010907 · Cited by 34
Synthesis of End-Cap Enabled Self-Immolative Photoresists For Extreme Ultraviolet Lithography
Deng, J., Bailey, S., Ai, R., Delmonico, A., Denbeaux, G., Jiang, S., & Ober, C. K. (2022) · ACS Macro Letters · doi:10.1021/acsmacrolett.2c00395 · Cited by 34
Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair
Cheng, A. Y., & Garcı́a, A. J. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.04.005 · Cited by 37
Photo-responsive smart surfaces with controllable cell adhesion
Hao, Y., Cui, H., Meng, J., & Wang, S. (2017) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2017.09.029 · Cited by 34
Mesenchylmal Stem Cell Culture on Poly(N-isopropylacrylamide) Hydrogel with Repeated Thermo-Stimulation
Akimoto, A. M., Niitsu, E., Nagase, K., Okano, T., Kanazawa, H., & Yoshida, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041253 · Cited by 34
Gelation Dynamics during Photo-Cross-Linking of Polymer Nanocomposite Hydrogels
Burroughs, M. C., Schloemer, T. H., Congreve, D. N., & Mai, D. J. (2022) · ACS Polymers Au · doi:10.1021/acspolymersau.2c00051 · Cited by 33
The effect of chondroitin sulfate concentration and matrix stiffness on chondrogenic differentiation of mesenchymal stem cells
Ai, C., Liu, L., Wong, K., Tan, X. H., & Goh, J. (2023) · Biomaterials Science · doi:10.1039/d2bm01980a · Cited by 35
Mechanomedicine
Liu, Z., Chen, J., Jo, M., Viola Vogel, B., Chen, J., Rogers, J. A., & Li, S. (2026) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00391-6 · Cited by 42
Injectable hydrogels derived from phosphorylated alginic acid calcium complexes
Kim, H., Song, M., Lee, E., & Shin, U. S. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.02.031 · Cited by 33
Cell adhesion mechanisms on laterally mobile polymer films
Kourouklis, A. P., Lerum, R. V., & Bermudez, H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.052 · Cited by 33
Optical cell separation from three-dimensional environment in photodegradable hydrogels for pure culture techniques
Tamura, M., Yanagawa, F., Sugiura, S., Takagi, T., Sumaru, K., Matsui, H., & Kanamori, T. (2014) · Scientific Reports · doi:10.1038/srep04793 · Cited by 33
Photocontrol of Biological Activities of Protein by Means of a Hydrogel
Murayama, S., & Kato, M. (2010) · Analytical Chemistry · doi:10.1021/ac1003757 · Cited by 33
Hydrogel scaffolds to study cell biology in four dimensions
Lewis, K. J. R., & Anseth, K. S. (2013) · MRS Bulletin · doi:10.1557/mrs.2013.54 · Cited by 33
Self-citation
Dual-purpose PEG scaffolds for the preparation of soft and biofunctional hydrogels: the convergence between CuAAC and thiol–ene reactions
Öberg, K., Hed, Y., Rahmn, I. J., Kelly, J., Löwenhielm, P., & Malkoch, M. (2013) · Chemical Communications · doi:10.1039/c3cc42084a · Cited by 33
Small Mesh Size Hydrogel for Functional Photocontrol of Encapsulated Enzymes and Small Probe Molecules
Murayama, S., Ishizuka, F., Takagi, K., Inoda, H., Sano, A., Santa, T., & Kato, M. (2011) · Analytical Chemistry · doi:10.1021/ac2023603 · Cited by 33
Rapid Aqueous Photouncaging by Red Light
Wang, X., & Kalow, J. A. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b00100 · Cited by 33
Leaving Groups as Traceless Topological Modifiers for the Synthesis of Topologically Isomeric Polymer Networks
Gu, Y., Schauenburg, D., Bode, J. W., & Johnson, J. A. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b07967 · Cited by 33
Chemical Approaches to Dynamically Modulate the Properties of Synthetic Matrices
LeValley, P. J., & Kloxin, A. M. (2018) · ACS Macro Letters · doi:10.1021/acsmacrolett.8b00808 · Cited by 33
Self-citation
The Influence of Ligand Density and Degradability on Hydrogel Induced Breast Cancer Dormancy and Reactivation
Farino, C. J., Pradhan, S., & Slater, J. H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002227 · Cited by 34
Biomaterials as a Vital Frontier for Stem Cell-Based Tissue Regeneration
Nugud, A. A. A., Alghfeli, L., Elmasry, M., Serafi, I. E., & El-Serafi, A. T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.713934 · Cited by 34
Advances in hydrogels for stem cell therapy: regulation mechanisms and tissue engineering applications
Liu, G., Zhou, Y., Zhang, X., & Guo, S. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01044e · Cited by 35

Authors: Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Kasko, Andrea M.
Anseth, Kristi S.
ORCID: Kloxin, April M.
Kasko, Andrea M.
Anseth, Kristi S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-04-03
Volume: 324
Issue: 5923
Pages: 59-63
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1169494
PMC: PMC2756032
OpenAlex: W2067897176
Cited by: 1,748
References: 34
Citations by year: 2026: 62 · 2025: 69 · 2024: 60 · 2023: 84 · 2022: 78 · 2021: 122 · 2020: 127 · 2019: 104 · 2018: 126 · 2017: 128 · 2016: 118 · 2015: 107 · 2014: 134 · 2013: 124 · 2012: 120
FWCI: 48.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Dental and Craniofacial Research (R01DE012998, DE16523, DE12998, R01DE016523)
Topics: Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords: photodegradable hydrogels, poly(ethylene glycol) hydrogels, dynamic hydrogels, cell migration, chondrogenic differentiation, stem cells, drug carriers, tissue engineering, encapsulated cells
MeSH terms: Acrylates, Cell Differentiation, Cell Movement, Cell Survival, Cross-Linking Reagents, Humans, Light, Oligopeptides, Photochemistry, Photolysis, Polyethylene Glycols, Polymers, Chondrocytes, Hydrogels, Chondrogenesis, Collagen Type II, Cell Line, Tumor, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks