The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Open accessAbstract
We report a strategy to create photodegradable poly(ethylene glycol)–based hydrogels through rapid polymerization of cytocompatible macromers for remote manipulation of gel properties in situ. Postgelation control of the gel properties was demonstrated to introduce temporal changes, creation of arbitrarily shaped features, and on-demand pendant functionality release. Channels photodegraded within a hydrogel containing encapsulated cells allow cell migration. Temporal variation of the biochemical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells. Photodegradable gels that allow real-time manipulation of material properties or chemistry provide dynamic environments with the scope to answer fundamental questions about material regulation of live cell function and may affect an array of applications from design of drug delivery vehicles to tissue engineering systems.
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“The viscoelastic profile of hydrogels has also been shown to define the mechanical confinement of growing organoids66.”
From Organoids (2022) · cites this paper as [66]
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“Manipulating synthetic hydrogels using methods such as electrospinning125, photopatterning126,127, spraying of microspheres128, inkjet and 3D printing129, or microfluidic channels130 further enables control over the shape and size of the organoids.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [126]
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E. I., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,875
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Silva, G. A., Czeisler, C. M., Niece, K. L., Beniash, E., Harrington, D. A., Kessler, J. A., & Stupp, S. I. (2004) · Science · doi:10.1126/science.1093783 · Cited by 2,179
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Myotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Advances in biomaterials, drug delivery, and bionanotechnology
Langer, R., & Peppas, N. A. (2003) · AIChE Journal · doi:10.1002/aic.690491202 · Cited by 982
Microengineered hydrogels for tissue engineering
Khademhosseini, A., & Langer, R. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.021 · Cited by 830
Microfabrication meets microbiology
Weibel, D. B., DiLuzio, W. R., & Whitesides, G. M. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1616 · Cited by 806
Research works printed but not linked: 2
- 10.1021/bm060086 · DOI
- S. J. Bryant, K. S. Anseth, in Scaffolding in Tissue Engineering, P. X. Ma, J. Elisseeff, Eds. (Marcel Dekker, New York, 2005), pp. 69–88.
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Macroporous nanowire nanoelectronic scaffolds for synthetic tissues
Tian, B., Liu, J., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., Suo, Z., Langer, R., Kohane, D. S., & Lieber, C. M. (2012) · Nature Materials · doi:10.1038/nmat3404 · Cited by 20
Metadata
- Authors
- Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kasko, Andrea M.
- Anseth, Kristi S.
- Venue
- Science
- Published
- 2009-04-03
- Volume
- 324
- Issue
- 5923
- Pages
- 59-63
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2756032
- OpenAlex
- W2067897176
- Cited by
- 1,748
- References
- 34
- Citations by year
- 2026: 62 · 2025: 69 · 2024: 60 · 2023: 84 · 2022: 78 · 2021: 122 · 2020: 127 · 2019: 104 · 2018: 126 · 2017: 128 · 2016: 118 · 2015: 107 · 2014: 134 · 2013: 124 · 2012: 120
- FWCI
- 48.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Dental and Craniofacial Research (R01DE012998, DE16523, DE12998, R01DE016523)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- photodegradable hydrogels, poly(ethylene glycol) hydrogels, dynamic hydrogels, cell migration, chondrogenic differentiation, stem cells, drug carriers, tissue engineering, encapsulated cells
- MeSH terms
- Acrylates, Cell Differentiation, Cell Movement, Cell Survival, Cross-Linking Reagents, Humans, Light, Oligopeptides, Photochemistry, Photolysis, Polyethylene Glycols, Polymers, Chondrocytes, Hydrogels, Chondrogenesis, Collagen Type II, Cell Line, Tumor, Mesenchymal Stem Cells
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