Cited by 1,748Hydrogels: synthesis, properties, applicationsPhotopolymerization techniques and applications3D Printing in Biomedical Research

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Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

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Kloxin, April M., Kasko, Andrea M., Salinas, Chelsea N., Anseth, Kristi S.·2009·Science

DOI 10.1126/science.1169494PMC PMC2756032

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Abstract

We report a strategy to create photodegradable poly(ethylene glycol)–based hydrogels through rapid polymerization of cytocompatible macromers for remote manipulation of gel properties in situ. Postgelation control of the gel properties was demonstrated to introduce temporal changes, creation of arbitrarily shaped features, and on-demand pendant functionality release. Channels photodegraded within a hydrogel containing encapsulated cells allow cell migration. Temporal variation of the biochemical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells. Photodegradable gels that allow real-time manipulation of material properties or chemistry provide dynamic environments with the scope to answer fundamental questions about material regulation of live cell function and may affect an array of applications from design of drug delivery vehicles to tissue engineering systems.

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Authors: Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Kasko, Andrea M.
Anseth, Kristi S.
ORCID: Kloxin, April M.
Kasko, Andrea M.
Anseth, Kristi S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-04-03
Volume: 324
Issue: 5923
Pages: 59-63
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1169494
PMC: PMC2756032
OpenAlex: W2067897176
Cited by: 1,748
References: 34
Citations by year: 2026: 62 · 2025: 69 · 2024: 60 · 2023: 84 · 2022: 78 · 2021: 122 · 2020: 127 · 2019: 104 · 2018: 126 · 2017: 128 · 2016: 118 · 2015: 107 · 2014: 134 · 2013: 124 · 2012: 120
FWCI: 48.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Dental and Craniofacial Research (R01DE012998, DE16523, DE12998, R01DE016523)
Topics: Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords: photodegradable hydrogels, poly(ethylene glycol) hydrogels, dynamic hydrogels, cell migration, chondrogenic differentiation, stem cells, drug carriers, tissue engineering, encapsulated cells
MeSH terms: Acrylates, Cell Differentiation, Cell Movement, Cell Survival, Cross-Linking Reagents, Humans, Light, Oligopeptides, Photochemistry, Photolysis, Polyethylene Glycols, Polymers, Chondrocytes, Hydrogels, Chondrogenesis, Collagen Type II, Cell Line, Tumor, Mesenchymal Stem Cells

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Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

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