Antibody Recognition of a Highly Conserved Influenza Virus Epitope

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Vectors Based on Modified Vaccinia Ankara Expressing Influenza H5N1 Hemagglutinin Induce Substantial Cross-Clade Protective Immunity

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Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

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Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response

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Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization

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Human Antibodies for Viral Infections

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Inhibition of Influenza A Virus (H1N1) Fusion by Benzenesulfonamide Derivatives Targeting Viral Hemagglutinin

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Hotspot-Centric De Novo Design of Protein Binders

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Influenza Surveillance: 2014–2015 H1N1 “Swine”-Derived Influenza Viruses from India

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Stable long‐term cultures of self‐renewing B cells and their applications

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In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice

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Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection

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Animal Models in Biomedical Research

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Vaccines against influenza A viruses in poultry and swine: Status and future developments

Rahn, J., Hoffmann, D., Harder, T., & Beer, M. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.052 · Cited by 51

Universal influenza vaccines: from viruses to nanoparticles

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Influenza A Virus Antibodies with Antibody-Dependent Cellular Cytotoxicity Function

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Designing Anti-Influenza Aptamers: Novel Quantitative Structure Activity Relationship Approach Gives Insights into Aptamer – Virus Interaction

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Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head

Wiersma, L., Rimmelzwaan, G. F., & de Vries, R. D. (2015) · Vaccines · doi:10.3390/vaccines3020239 · Cited by 48

Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses

Lin, S.-C., Liu, W., Jan, J., & Wu, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092822 · Cited by 48

The road to a more effective influenza vaccine: Up to date studies and future prospects

Sano, K., Ainai, A., Suzuki, T., & Hasegawa, H. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.08.034 · Cited by 49

Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses

Jang, Y. H., Byun, Y. H., Lee, Y. J., Lee, Y. H., Lee, K. H., & Seong, B. L. (2012) · Journal of Virology · doi:10.1128/jvi.07149-11 · Cited by 47

A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains

Doyle, T. M., Li, C., Bucher, D. J., Hashem, A. M., Domselaar, G. V., Wang, J., Farnsworth, A., She, Y., Cyr, T. D., He, R., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.041 · Cited by 47

Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer

Lee, P. S., Zhu, X., Yu, W., & Wilson, I. A. (2015) · Journal of Virology · doi:10.1128/jvi.00808-15 · Cited by 47

Profiling of Humoral Response to Influenza A(H1N1)pdm09 Infection and Vaccination Measured by a Protein Microarray in Persons with and without History of Seasonal Vaccination

Huijskens, E. G. W., Reimerink, J. H. J., Mulder, P. G. H., van Beek, J., Meijer, A., de Bruin, E., Friesema, I. H. M., de Jong, M. D., Rimmelzwaan, G. F., Peeters, M. F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054890 · Cited by 47

Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage

Lu, X., Shi, Y., Gao, F., Xiao, H., Wang, M., Qi, J., & Gao, G. F. (2012) · Journal of Virology · doi:10.1128/jvi.01606-12 · Cited by 46

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

Turner, H. L., Pallesen, J., Lang, S., Bangaru, S., Urata, S. M., Li, S., Cottrell, C. A., Bowman, C. A., Crowe, J. E., Wilson, I. A., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000139 · Cited by 47

Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene

Wu, N. C., Yamayoshi, S., Ito, M., Uraki, R., Kawaoka, Y., & Wilson, I. A. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.09.010 · Cited by 47

Diminished B-Cell Response After Repeat Influenza Vaccination

Sanyal, M., Holmes, T. H., Maecker, H. T., Albrecht, R. A., Dekker, C. L., He, X.-S., & Greenberg, H. B. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy685 · Cited by 47

Protect, modify, deprotect (PMD): A strategy for creating vaccines to elicit antibodies targeting a specific epitope

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Mathematical model reveals the role of memory CD8 T cell populations in recall responses to influenza

Zarnitsyna, V. I., Handel, A., McMaster, S. R., Hayward, S. L., Kohlmeier, J. E., & Antia, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00165 · Cited by 42

Unique features of a recombinant haemagglutinin influenza vaccine that influence vaccine performance

Arunachalam, B., Post, P. L., & Rudin, D. (2021) · npj Vaccines · doi:10.1038/s41541-021-00403-7 · Cited by 48

Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses

Li, T., Chen, J., Zheng, Q., Xue, W., Zhang, L., Rong, R., Zhang, S., Wang, Q., Hong, M., Zhang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32926-5 · Cited by 46

Heterosubtype Neutralizing Responses to Influenza A (H5N1) Viruses Are Mediated by Antibodies to Virus Haemagglutinin

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Molecular and antigenic characterization of H9N2 avian influenza virus isolates from chicken flocks between 1998 and 2007 in China

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Small Molecule Inhibitors of Influenza Virus Entry

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LL2 Fab in complex with anti-Kappa VHH domain

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The Breadth of Cross Sub-Type Neutralisation Activity of a Single Domain Antibody to Influenza Hemagglutinin Can Be Increased by Antibody Valency

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A Triclade DNA Vaccine Designed on the Basis of a Comprehensive Serologic Study Elicits Neutralizing Antibody Responses against All Clades and Subclades of Highly Pathogenic Avian Influenza H5N1 Viruses

Zhou, F., Wang, G., Buchy, P., Cai, Z., Chen, H., Chen, Z., Cheng, G., Wan, X., Deubel, V., & Zhou, P. (2012) · Journal of Virology · doi:10.1128/jvi.06930-11 · Cited by 45

Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy

Lindsay, B. J., Bonar, M. M., Costas-Cancelas, I. N., Hunt, K., Makarkov, A. I., Chierzi, S., Krawczyk, C. M., Landry, N., Ward, B. J., & Rouiller, I. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.02.106 · Cited by 45

Assessing the Protective Potential of H1N1 Influenza Virus Hemagglutinin Head and Stalk Antibodies in Humans

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Antibody-guided structure-based vaccines

Kwong, P. D., DeKosky, B. J., & Ulmer, J. B. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101428 · Cited by 43

Is It Possible to Develop a “Universal” Influenza Virus Vaccine?Preprint

Andrews, S. F., Graham, B. S., Mascola, J. R., & McDermott, A. B. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029413 · Cited by 45

Analysis of the conserved protective epitopes of hemagglutinin on influenza A viruses

Jiao, C., Wang, B., Chen, P., Jiang, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1086297 · Cited by 44

Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase

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Emerging trends and therapeutic applications of monoclonal antibodies

Ramaiah, M. J., Nalluri, H. P., Reddy, P. N., Sainath, S. B., Kumar, N. S. S., Sai Kiran, G. V. S. D., Dhiman, R., Chamarthy, S., Komaragiri, R. R., Manyam, R. R., et al. (2024) · Gene · doi:10.1016/j.gene.2024.148607 · Cited by 45

Influenza Vaccines

Schultz‐Cherry, S., & Jones, J. C. (2010) · Advances in virus research · doi:10.1016/b978-0-12-385034-8.00003-x · Cited by 44

Options and Obstacles for Designing a Universal Influenza Vaccine

Jang, Y. H., & Seong, B. L. (2014) · Viruses · doi:10.3390/v6083159 · Cited by 44

Mechanism of Glycan Receptor Recognition and Specificity Switch for Avian, Swine, and Human Adapted Influenza Virus Hemagglutinins: A Molecular Dynamics Perspective

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Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in Macaques

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Design and utilization of epitope-based databases and predictive tools

Salimi, N., Fleri, W., Peters, B., & Sette, A. (2010) · Immunogenetics · doi:10.1007/s00251-010-0435-2 · Cited by 44

Secondary mechanisms of diversification in the human antibody repertoire

Briney, B. S., & Crowe, J. E. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00042 · Cited by 44

Sequential Infection in Ferrets with Antigenically Distinct Seasonal H1N1 Influenza Viruses Boosts Hemagglutinin Stalk-Specific Antibodies

Kirchenbaum, G. A., Carter, D. M., & Ross, T. M. (2015) · Journal of Virology · doi:10.1128/jvi.02372-15 · Cited by 44

Influenza (Including Avian Influenza and Swine Influenza)

Treanor, J. J. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00167-3 · Cited by 44

Age‐related factors that affect B cell responses to vaccination in mice and humans

Frasca, D., Blomberg, B. B., Garcia, D., Keilich, S. R., & Haynes, L. (2020) · Immunological Reviews · doi:10.1111/imr.12864 · Cited by 42

IGHV1-69 B Cell Chronic Lymphocytic Leukemia Antibodies Cross-React with HIV-1 and Hepatitis C Virus Antigens as Well as Intestinal Commensal Bacteria

Hwang, K., Trama, A. M., Kozink, D. M., Chen, X., Wiehe, K. J., Cooper, A. J., Xia, S.-M., Wang, M., Marshall, D. J., Whitesides, J. F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090725 · Cited by 44

Maturation of germinal center B cells after influenza virus vaccination in humans

McIntire, K. M., Meng, H., Lin, T.-H., Kim, W., Moore, N. E., Han, J., McMahon, M., Wang, M., Malladi, S. K., Mohammed, B. M., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240668 · Cited by 41

In Silico Study of Rotavirus VP7 Surface Accessible Conserved Regions for Antiviral Drug/Vaccine Design

Ghosh, A., Chattopadhyay, S., Chawla‐Sarkar, M., Nandy, P. S., & Nandy, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040749 · Cited by 43

Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses

Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., Wang, F., Zhang, H., Chen, H., Ding, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13577 · Cited by 43

Development of a Pan-H1 Influenza Vaccine

Darricarrère, N., Pougatcheva, S. O., Duan, X., Rudicell, R. S., Chou, T.-H. W., DiNapoli, J. M., Ross, T. M., Alefantis, T., Vogel, T. U., Kleanthous, H., et al. (2018) · Journal of Virology · doi:10.1128/jvi.01349-18 · Cited by 42

Neutralizing Antibodies Targeting the Conserved Stem Region of Influenza Hemagglutinin

Neerukonda, S. N., Vassell, R. A., & Weiss, C. D. (2020) · Vaccines · doi:10.3390/vaccines8030382 · Cited by 42

50 Years of structural immunology

Wilson, I. A., & Stanfield, R. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100745 · Cited by 44

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Saito, M., Itoh, Y., Yasui, F., Munakata, T., Yamane, D., Ozawa, M., Ito, R., Katoh, T., Ishigaki, H., Nakayama, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22964-w · Cited by 43

A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

Andrews, S. F., Raab, J. E., Gorman, J., Gillespie, R. A., Cheung, C. S. F., Rawi, R., Cominsky, L. Y., Boyington, J. C., Creanga, A., Shen, C., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01636-8 · Cited by 43

Targeting neuraminidase: the next frontier for broadly protective influenza vaccines

Wu, N. C., & Ellebedy, A. H. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.11.001 · Cited by 42

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

deCamp, A. C., Corcoran, M., Fulp, W. J., Willis, J. R., Cottrell, C. A., Bader, D. L., Kalyuzhniy, O., Leggat, D. J., Cohen, K. W., Hyrien, O., et al. (2024) · npj Vaccines · doi:10.1038/s41541-024-00811-5 · Cited by 43

Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus

Srivastava, V., Yang, Z., Hung, I. F., Xu, J., Zheng, B., & Zhang, Y. (2013) · Journal of Virology · doi:10.1128/jvi.00273-13 · Cited by 42

Evolutionary Pathways of the Pandemic Influenza A (H1N1) 2009 in the UK

Galiano, M., Agapow, P., Thompson, C., Platt, S., Underwood, A. P., Ellis, J., Myers, R. E., Green, J., & Zambon, M. C. F. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023779 · Cited by 42

Lessons from Reverse Vaccinology for viral vaccine design

Bruno, L., Cortese, M., Rappuoli, R., & Merola, M. (2015) · Current Opinion in Virology · doi:10.1016/j.coviro.2015.03.001 · Cited by 43

Prospects of HA-Based Universal Influenza Vaccine

Hashem, A. M. (2015) · BioMed Research International · doi:10.1155/2015/414637 · Cited by 43

Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry

Kim, M., Song, L., Moon, J. J., Sun, Z.-Y. J., Bershteyn, A., Hanson, M. C., Cain, D. W., Goka, S. Q., Kelsoe, G. H., Wagner, G., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.494609 · Cited by 42

Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient

Hu, W., Chen, A., Miao, Y., Xia, S., Ling, Z., Xu, K., Wang, T., Xu, Y. M., Cui, J., Wu, H., et al. (2012) · Virology · doi:10.1016/j.virol.2012.09.034 · Cited by 42

Homologous and heterologous antigenic matched vaccines containing different H5 hemagglutinins provide variable protection of chickens from the 2014 U.S. H5N8 and H5N2 clade 2.3.4.4 highly pathogenic avian influenza viruses

Kapczynski, D. R., Pantin‐Jackwood, M. J., Spackman, E., Chrząstek, K., Suarez, D. L., & Swayne, D. E. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.04.042 · Cited by 42

A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface

McCarthy, K. R., Lee, J., Watanabe, A., Kuraoka, M., Robinson‐McCarthy, L. R., Georgiou, G., Kelsoe, G. H., & Harrison, S. C. (2021) · mBio · doi:10.1128/mbio.01144-21 · Cited by 42

Pre‐ and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir

Koudstaal, W., Koldijk, M. H., Brakenhoff, J. P. J., Cornelissen, L. A. H. M., Weverling, G. J., Friesen, R. H. E., & Goudsmit, J. (2009) · The Journal of Infectious Diseases · doi:10.1086/648378 · Cited by 42

Computational Design of Novel Protein Binders and Experimental Affinity Maturation

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Next-Generation Influenza VaccinesPreprint

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Research highlights

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A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

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An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

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