Antibody Recognition of a Highly Conserved Influenza Virus Epitope

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Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors

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Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms

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Characterization of lentiviral pseudotypes with influenza H5N1 hemagglutinin and their performance in neutralization assays

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The Human Antibody Response to the Influenza Virus Neuraminidase Following Infection or Vaccination

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Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody

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Emerged HA and NA Mutants of the Pandemic Influenza H1N1 Viruses with Increasing Epidemiological Significance in Taipei and Kaohsiung, Taiwan, 2009–10

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Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2

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Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on the Influenza Virus H5N1 Hemagglutinin

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Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients

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Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation

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Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge

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T and B Cell Immune Responses to Influenza Viruses in Pigs

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Why are vaccines against many human viral diseases still unavailable; an historic perspective?

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Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

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Antibodies against conserved antigens provide opportunities for reform in influenza vaccine design

Kaminski, D. A. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00076 · Cited by 38

Cell‐free production of trimeric influenza hemagglutinin head domain proteins as vaccine antigens

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Erratum: Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection

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New England harbor seal H3N8 influenza virus retains avian-like receptor specificity

Hussein, I. T. M., Krammer, F., Ma, E. J., Estrin, M., Viswanathan, K., Stebbins, N. W., Quinlan, D. S., Sasisekharan, R., & Runstadler, J. A. (2016) · Scientific Reports · doi:10.1038/srep21428 · Cited by 37

Max Bergmann lecture Protein epitope mimetics in the age of structural vaccinology

Robinson, J. A. (2013) · Journal of Peptide Science · doi:10.1002/psc.2482 · Cited by 36

Unraveling of a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin

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Novel vaccines against influenza viruses

Kang, S. M., Song, J. M., & Compans, R. W. (2011) · Virus Research · doi:10.1016/j.virusres.2011.09.037 · Cited by 37

Protection against Multiple Subtypes of Influenza Viruses by Virus-Like Particle Vaccines Based on a Hemagglutinin Conserved Epitope

Chen, S., Zheng, D., Li, C., Zhang, W., Xu, W., Liu, X., Fang, F., & Chen, Z. (2015) · BioMed Research International · doi:10.1155/2015/901817 · Cited by 37

Epitope-focused vaccine design against influenza A and B viruses

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Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences

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Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain

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An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

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Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity

Hervé, P., Lorin, V., Jouvion, G., Costa, B. D., & Escriou, N. (2015) · Virology · doi:10.1016/j.virol.2015.08.033 · Cited by 36

Vaccine design of hemagglutinin glycoprotein against influenza

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IgM, IgG, and IgA Antibody Responses to Influenza A(H1N1)pdm09 Hemagglutinin in Infected Persons during the First Wave of the 2009 Pandemic in the United States

Li, Z., Lin, S., Carney, P. J., Li, J., Liu, F., Lu, X., Liu, M., Stevens, J., Levine, M. Z., Katz, J. M., et al. (2014) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00129-14 · Cited by 36

Label-free detection and characterization of the binding of hemagglutinin protein and broadly neutralizing monoclonal antibodies using terahertz spectroscopy

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Cross‐reactive humoral responses to influenza and their implications for a universal vaccine

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Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV ‐1

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The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza

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Universal Influenza Vaccines: Progress in Achieving Broad Cross-Protection In Vivo

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Protein- and Peptide-Based Virus Inactivators: Inactivating Viruses Before Their Entry Into Cells

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Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 Subtype

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Oligomeric Recombinant H5 HA1 Vaccine Produced in Bacteria Protects Ferrets from Homologous and Heterologous Wild-Type H5N1 Influenza Challenge and Controls Viral Loads Better than Subunit H5N1 Vaccine by Eliciting High-Affinity Antibodies

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Current Landscape of Antiviral Drug Discovery

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The use of databases, data mining and immunoinformatics in vaccinology: where are we?

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Viva la revolución: rethinking influenza A virus antigenic drift

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In Vivo Imaging of Influenza Virus Infection in Immunized Mice

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Characterization of Hemagglutinin Antigens on Influenza Virus and within Vaccines Using Electron Microscopy

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Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

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Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells

Miyauchi, K., Adachi, Y., Tonouchi, K., Yajima, T., Harada, Y., Fukuyama, H., Deno, S., Iwakura, Y., Yoshimura, A., Hasegawa, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24090-z · Cited by 30

Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay

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Potential Broad-Spectrum Antiviral Agents: A Key Arsenal Against Newly Emerging and Reemerging Respiratory RNA Viruses

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Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin

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AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

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Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

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Progress on adenovirus-vectored universal influenza vaccines

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Design and Synthesis of Benzenesulfonamide Derivatives as Potent Anti-Influenza Hemagglutinin Inhibitors

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Free-Energy Simulations Reveal that Both Hydrophobic and Polar Interactions Are Important for Influenza Hemagglutinin Antibody Binding

Xia, Z., Huynh, T., Kang, S.-G., & Zhou, R. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.01.043 · Cited by 34

Evolutionary dynamics of the influenza A pandemic (H1N1) 2009 virus with emphasis on Indian isolates: Evidence for adaptive evolution in the HA gene

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Pre-pandemic and pandemic influenza vaccines

Rockman, S. P., & Brown, L. E. (2010) · Human Vaccines · doi:10.4161/hv.6.10.12915 · Cited by 33

Cross-Protective Immune Responses Elicited by Live Attenuated Influenza Vaccines

Jang, Y. H., & Seong, B. L. (2013) · Yonsei Medical Journal · doi:10.3349/ymj.2013.54.2.271 · Cited by 33

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate

Tran, E. E. H., Podolsky, K. A., Bartesaghi, A., Kuybeda, O., Grandinetti, G., Wohlbold, T. J., Tan, G. S., Nachbagauer, R., Palese, P., Krammer, F., et al. (2016) · mBio · doi:10.1128/mbio.00257-16 · Cited by 33

Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies

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Shaping a universally broad antibody response to influenza amidst a variable immunoglobulin landscape

Andrews, S. F., & McDermott, A. B. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.04.009 · Cited by 33

Naïve Human Antibody Libraries for Infectious Diseases

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Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth

Qiu, Y., Stegalkina, S. S., Zhang, J., Boudanova, E., Park, A., Zhou, Y., Prabakaran, P., Pougatcheva, S. O., Ustyugova, I. V., Vogel, T. U., et al. (2019) · Journal of Virology · doi:10.1128/jvi.01035-19 · Cited by 33

Convergent antibody evolution and clonotype expansion following influenza virus vaccination

Forgacs, D., Abreu, R. B., Sautto, G. A., Kirchenbaum, G. A., Drábek, E. F., Williamson, K. S., Kim, D., Emerling, D. E., & Ross, T. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247253 · Cited by 33

Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?

Zhan, W., Muhuri, M., Tai, P. W. L., & Gao, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673699 · Cited by 35

A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

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The highly conserved HA2 protein of the influenza a virus induces a cross protective immune response

Lee, J., Chowdhury, M. Y. E., Moon, H.-J., Choi, Y. K., Talactac, M. R., Kim, J. H., Park, M.-E., Son, H., Shin, K.-S., & Kim, C. (2013) · Journal of Virological Methods · doi:10.1016/j.jviromet.2013.08.022 · Cited by 33

M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza

Hatta, Y., Boltz, D. A., Sarawar, S. R., Kawaoka, Y., Neumann, G., & Bilsel, P. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.06.039 · Cited by 33

Multi-Dimensional Measurement of Antibody-Mediated Heterosubtypic Immunity to Influenza

Wang, J., Hilchey, S. P., Hyrien, O., Huertas, N., Perry, S., Manojkumar, R., Bucher, D. J., & Zand, M. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129858 · Cited by 32

A Critical HA1 Neutralizing Domain of H5N1 Influenza in an Optimal Conformation Induces Strong Cross-Protection

Du, L., Zhao, G., Sun, S., Zhang, X., Zhou, X., Guo, Y., Li, Y., Zhou, Y., & Jiang, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053568 · Cited by 32

Prospects for Broadly Protective Influenza Vaccines

Treanor, J. J. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.09.012 · Cited by 32

Influenza H7N9 LAH-HBc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses

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Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation

Goh, B. C., Rynkiewicz, M. J., Cafarella, T. M., White, M. R., Hartshorn, K. L., Allen, K., Crouch, E. C., Calin, O., Seeberger, P. H., Schulten, K. J., et al. (2013) · Biochemistry · doi:10.1021/bi4010683 · Cited by 31

Antibody Responses to Trivalent Inactivated Influenza Vaccine in Health Care Personnel Previously Vaccinated and Vaccinated for The First Time

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An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations

Rajendran, M., Sun, W., Comella, P., Nachbagauer, R., Wohlbold, T. J., Amanat, F., Roubidoux, E. K., Palese, P., & Krammer, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194830 · Cited by 31

Glycosylation as a tool for rational vaccine design

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Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19

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Stabilized recombinant SARS-CoV-2 spike antigen enhances vaccine immunogenicity and protective capacity

zu Natrup, C. M., Tscherne, A., Dahlke, C., Ciurkiewicz, M., Shin, D., Fathi, A., Rohde, C., Kalodimou, G., Halwe, S., Limpinsel, L., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci159895 · Cited by 32

Nanovaccines Displaying the Influenza Virus Hemagglutinin in an Inverted Orientation Elicit an Enhanced Stalk‐Directed Antibody Response

Frey, S. J., Carreño, J. M., Bielak, D. A., Arsiwala, A., Altomare, C. G., Varner, C., Rosen‐Cheriyan, T., Bajic, G., Krammer, F., & Kane, R. S. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202729 · Cited by 31

Insect larvae biofactories as a platform for influenza vaccine production

Gómez-Casado, E., Gómez-Sebastián, S., Núñez, M. C., Lasa, R., Martínez-Pulgarín, S., & Escribano, J. M. (2011) · Protein Expression and Purification · doi:10.1016/j.pep.2011.03.007 · Cited by 31

Cross-Linking of Rotavirus Outer Capsid Protein VP7 by Antibodies or Disulfides Inhibits Viral Entry

Aoki, S. T., Trask, S. D., Coulson, B. S., Greenberg, H. B., Dormitzer, P. R., & Harrison, S. C. (2011) · Journal of Virology · doi:10.1128/jvi.00234-11 · Cited by 31

Antibody-mediated NK cell activation as a correlate of immunity against influenza infection

Boudreau, C. M., Burke, J. S., Yousif, A. S., Sangesland, M., Jastrzebski, S. L., Verschoor, C. P., Kuchel, G. A., Lingwood, D., Kleanthous, H., Bruijn, I. D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40699-8 · Cited by 30

Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

Ray, R., Mohamed, F. A. N., Maurer, D. P., Huang, J., Alpay, B. A., Ronsard, L., Xie, Z., Han, J., Fernández‐Quintero, M. L., Phan, Q. A., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.022 · Cited by 30

Antivirals in seasonal and pandemic influenza—future perspectives*

Wathen, M. W., Barro, M., & Bright, R. A. (2012) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12049 · Cited by 30

Influenza virus antigenicity and broadly neutralizing epitopes

Air, G. M. (2015) · Current Opinion in Virology · doi:10.1016/j.coviro.2015.03.006 · Cited by 30

Characterization of the hemagglutinin gene of subtype H9 avian influenza viruses isolated in 2007–2009 in China

Ji, K., Jiang, W., Liu, S., Chen, J., Chen, J., Hou, G., Li, J., & Huang, B. (2009) · Journal of Virological Methods · doi:10.1016/j.jviromet.2009.09.013 · Cited by 30

Two Glycosylation Sites in H5N1 Influenza Virus Hemagglutinin That Affect Binding Preference by Computer-Based Analysis

Chen, W., Sun, S., & Li, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038794 · Cited by 30

New Strategies for the Development of H5N1 Subtype Influenza Vaccines

Steel, J. (2011) · BioDrugs · doi:10.1007/bf03256169 · Cited by 30

Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

Rosario, J. M. M. D., Smith, M. D., Zaki, K., Risley, P., Temperton, N. J., Engelhardt, O. G., Collins, M. K., Takeuchi, Y., & Hufton, S. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00627 · Cited by 31

Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines

Sangesland, M., & Lingwood, D. (2021) · Vaccines · doi:10.3390/vaccines9020125 · Cited by 34

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

Holzer, B., Rijal, P., McNee, A., Paudyal, B., Martini, V., Clark, B., Manjegowda, T., Salguero, F. J., Bessell, E., Schwartz, J. C., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009330 · Cited by 30

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Thornlow, D. N., Macintyre, A. N., Oguin, T. H., Karlsson, A., Stover, E. L., Lynch, H. E., Sempowski, G. D., & Schmidt, A. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737973 · Cited by 30

The Universal Epitope of Influenza A Viral Neuraminidase Fundamentally Contributes to Enzyme Activity and Viral Replication

Doyle, T. M., Jaentschke, B., Domselaar, G. V., Hashem, A. M., Farnsworth, A., Forbes, N. E., Li, C., Wang, J., He, R., Brown, E. G., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.468884 · Cited by 30

Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses

Mahallawi, W. H., Kasbekar, A. V., McCormick, M. S., Höschler, K., Temperton, N. J., Leong, S. C., Beer, H., Ferrara, F., McNamara, P. S., & Zhang, Q. (2013) · Journal of Virology · doi:10.1128/jvi.03547-12 · Cited by 30

Synthetic Peptide Vaccine Targeting a Cryptic Neutralizing Epitope in Domain 2 ofBacillus anthracisProtective Antigen

Oscherwitz, J., Yu, F., Jacobs, J. L., Liu, T.-H., Johnson, P. R., & Cease, K. B. (2009) · Infection and Immunity · doi:10.1128/iai.00358-09 · Cited by 31

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Großkopf, A. K., Ensser, A., Neipel, F., Jungnickl, D., Schlagowski, S., Desrosiers, R. C., & Hahn, A. S. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006912 · Cited by 30

What Are the Most Powerful Immunogen Design Vaccine Strategies?Preprint

Kwong, P. D. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029470 · Cited by 30

Human monoclonal antibodies targeting A35 protect from death caused by mpox

Fantin, R. F., Yuan, M., Park, S., Bozarth, B., Cohn, H., Ignacio, M. A., Earl, P. L., Civljak, A., Laghlali, G., Zhang, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.08.004 · Cited by 34

Advances in the development of universal influenza vaccines

Gilbert, S. C. (2012) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12013 · Cited by 29

Adenoviral vectors as novel vaccines for influenza

Coughlan, L., Mullarkey, C. E., & Gilbert, S. C. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12350 · Cited by 29

A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., Wang, F., Zhou, F., Wang, G., Tsai, C., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06665-11 · Cited by 72

Research highlights

(2009) · Nature Biotechnology · doi:10.1038/nbt0409-348

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M. A. C., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 820

A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

(2016)

An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Lee, C., Yang, C.-Y., Lin, L., Ko, T., Chang, A., Chang, S. S.-C., & Wang, A. H. ‐. (2019) · Scientific Reports · doi:10.1038/s41598-019-40937-4 · Cited by 22