Antibody Recognition of a Highly Conserved Influenza Virus Epitope

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Guiding the Immune Response against Influenza Virus Hemagglutinin toward the Conserved Stalk Domain by Hyperglycosylation of the Globular Head Domain

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A common solution to group 2 influenza virus neutralization

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An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

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Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity

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A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus

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Antibody therapies for the prevention and treatment of viral infections

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A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates

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Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

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Monoclonal antibody-based therapies for microbial diseases

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Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

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Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

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Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System

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Mechanisms of Hemagglutinin Targeted Influenza Virus Neutralization

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Potent peptidic fusion inhibitors of influenza virus

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H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination

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Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities

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H3N2 Influenza Virus Infection Induces Broadly Reactive Hemagglutinin Stalk Antibodies in Humans and Mice

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A Pan-H1 Anti-Hemagglutinin Monoclonal Antibody with Potent Broad-Spectrum EfficacyIn Vivo

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Host response to influenza virus: protection versus immunopathology

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Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development

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Influenza vaccine immunology

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Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture

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How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

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Immunological assessment of influenza vaccines and immune correlates of protection

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Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

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The role of Fc–FcγR interactions in IgG-mediated microbial neutralization

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In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies

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Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine

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Induction of Broadly Reactive Anti-Hemagglutinin Stalk Antibodies by an H5N1 Vaccine in Humans

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A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

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MF59 adjuvant: the best insurance against influenza strain diversity

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Broadly neutralizing antibodies against influenza virus and prospects for universal therapies

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High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution

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Tools to therapeutically harness the human antibody response

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Molecular Basis for Broad Neuraminidase Immunity: Conserved Epitopes in Seasonal and Pandemic H1N1 as Well as H5N1 Influenza Viruses

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Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin

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Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

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Unsupervised evolution of protein and antibody complexes with a structure-informed language model

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A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans

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Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy

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Structural vaccinology starts to deliver

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Intranasal Vaccination with 1918 Influenza Virus-Like Particles Protects Mice and Ferrets from Lethal 1918 and H5N1 Influenza Virus Challenge

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Therapeutic antibodies, vaccines and antibodyomes

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Structure and Immune Recognition of the HIV Glycan Shield

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A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

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Inactivated influenza vaccines

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Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets

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Structural Characterization of an Early Fusion Intermediate of Influenza Virus Hemagglutinin

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Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

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Tackling influenza with broadly neutralizing antibodies

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Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

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A comprehensive map of the influenza A virus replication cycle

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Community-Wide Assessment of Protein-Interface Modeling Suggests Improvements to Design Methodology

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Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

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Modified Vaccinia Virus Ankara (MVA) as Production Platform for Vaccines against Influenza and Other Viral Respiratory Diseases

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Wide Prevalence of Heterosubtypic Broadly Neutralizing Human Anti-Influenza A Antibodies

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HIV-1 and influenza antibodies: seeing antigens in new ways

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Preexisting human antibodies neutralize recently emerged H7N9 influenza strains

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Broad protection against influenza infection by vectored immunoprophylaxis in mice

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Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

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Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

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Stalking influenza by vaccination with pre-fusion headless HA mini-stem

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Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem

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VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design

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Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses

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Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

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Influenza-Specific Antibody-Dependent Cellular Cytotoxicity: Toward a Universal Influenza Vaccine

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Emerging Antiviral Strategies to Interfere with Influenza Virus Entry

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Characterization of a Broadly Neutralizing Monoclonal Antibody That Targets the Fusion Domain of Group 2 Influenza A Virus Hemagglutinin

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The current challenges for vaccine development

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Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin

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Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

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Structural basis of influenza virus neutralization

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Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2

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A shared structural solution for neutralizing ebolaviruses

Dias, J. M., Kuehne, A. I., Abelson, D. M., Bale, S., Wong, A. C., Halfmann, P., Muhammad, M. A., Fusco, M. L., Zak, S. E., Kang, E. H., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2150 · Cited by 116

Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism

Sun, X., Shi, Y., Lu, X., He, J., Gao, F., Yan, J., Qi, J., & Gao, G. F. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.025 · Cited by 116

Challenges for structure-based HIV vaccine design

Schief, W. R., Ban, Y. A., & Stamatatos, L. (2009) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32832e6184 · Cited by 117

The Individual and Population Genetics of Antibody Immunity

Watson, C. T., Glanville, J., & Marasco, W. A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.04.003 · Cited by 116

Preferential induction of cross-group influenza A hemagglutinin stem–specific memory B cells after H7N9 immunization in humans

Andrews, S. F., Joyce, M. G., Chambers, M. J., Gillespie, R. A., Kanekiyo, M., Leung, K., Yang, E. S., Tsybovsky, Y., Wheatley, A. K., Crank, M. C., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan2676 · Cited by 116

Nanobodies With In Vitro Neutralizing Activity Protect Mice Against H5N1 Influenza Virus Infection

Ibañez, L. I., Filette, M. D., Hultberg, A., Verrips, T. C., Temperton, N. J., Weiss, R. A., Vandevelde, W., Schepens, B., Vanlandschoot, P., & Saelens, X. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq168 · Cited by 116

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

Palese, P., & Wang, T. T. (2011) · mBio · doi:10.1128/mbio.00150-11 · Cited by 115

Advances in Universal Influenza Virus Vaccine Design and Antibody Mediated Therapies Based on Conserved Regions of the Hemagglutinin

Krammer, F., Palese, P., & Steel, J. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_408 · Cited by 115

Potential neutralizing antibodies discovered for novel corona virus using machine learning

Magar, R., Yadav, P., & Barati Farimani, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84637-4 · Cited by 114

Immunodominance of Antigenic Site B over Site A of Hemagglutinin of Recent H3N2 Influenza Viruses

Popova, L. I., Smith, K., West, A. H., Wilson, P. C., James, J. A., Thompson, L. F., & Air, G. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041895 · Cited by 113

Linear polysialoside outperforms dendritic analogs for inhibition of influenza virus infection in vitro and in vivo

Bhatia, S., Lauster, D. C., Bardua, M., Ludwig, K., Angioletti‐Uberti, S., Popp, N., Hoffmann, U., Paulus, F., Budt, M., Stadtmüller, M., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.028 · Cited by 113

Antivirals Targeting Influenza A Virus

Das, K. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300455c · Cited by 112

Intranasal Antibody Gene Transfer in Mice and Ferrets Elicits Broad Protection Against Pandemic Influenza

Limberis, M. P., Adam, V. S., Wong, G., Gren, J., Kobasa, D., Ross, T. M., Kobinger, G. P., Tretiakova, A. P., & Wilson, J. M. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006299 · Cited by 114

Animal Models for Influenza Viruses: Implications for Universal Vaccine Development

Margine, I., & Krammer, F. (2014) · Pathogens · doi:10.3390/pathogens3040845 · Cited by 112

Research and development of universal influenza vaccines

Du, L., Zhou, Y., & Jiang, S. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.01.001 · Cited by 111

A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

Wang, Y., Yuan, M., Lv, H., Peng, J., Wilson, I. A., & Wu, N. C. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.019 · Cited by 119

Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5

Ohshima, N., Iba, Y., Kubota‐Koketsu, R., Asano, Y., Okuno, Y., & Kurosawa, Y. (2011) · Journal of Virology · doi:10.1128/jvi.05397-11 · Cited by 111

Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

Dreyfus, C., Ekiert, D. C., & Wilson, I. A. (2013) · Journal of Virology · doi:10.1128/jvi.02975-12 · Cited by 110

Universal anti-neuraminidase antibody inhibiting all influenza A subtypes

Doyle, T. M., Hashem, A. M., Li, C., Domselaar, G. V., Larocque, L., Wang, J., Smith, D. G. S., Cyr, T. D., Farnsworth, A., He, R., et al. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.09.018 · Cited by 110

Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

Harris, A. K., Meyerson, J. R., Matsuoka, Y., Kuybeda, O., Moran, A., Bliss, D., Das, S. R., Yewdell, J. W., Sapiro, G., Subbarao, K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214913110 · Cited by 110

Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem

Thomson, C. A., Wang, Y., Jackson, L. M., Olson, M., Wang, W., Liavonchanka, A., Keleta, L., da Silva, V. G. L., Diederich, S., Jones, R. B., et al. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00087 · Cited by 109

Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

Khurana, S., Hahn, M., Coyle, E. M., King, L. R., Lin, T.-L., Treanor, J., Sant, A., & Golding, H. (2019) · Nature Communications · doi:10.1038/s41467-019-11296-5 · Cited by 101

A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., Wang, F., Zhou, F., Wang, G., Tsai, C., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06665-11 · Cited by 72

Research highlights

(2009) · Nature Biotechnology · doi:10.1038/nbt0409-348

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M. A. C., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 820

A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

(2016)

An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Lee, C., Yang, C.-Y., Lin, L., Ko, T., Chang, A., Chang, S. S.-C., & Wang, A. H. ‐. (2019) · Scientific Reports · doi:10.1038/s41598-019-40937-4 · Cited by 22