Antibody Recognition of a Highly Conserved Influenza Virus Epitope

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Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice

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A Complex Dance: Measuring the Multidimensional Worlds of Influenza Virus Evolution and Anti-Influenza Immune Responses

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Structural dynamics reveal subtype-specific activation and inhibition of influenza virus hemagglutinin

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Impact of preexisting memory to seasonal A / H 1 N 1 influenza virus on the immune response following vaccination against avian A / H 5 N 1 virus

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Extreme Evolutionary Conservation of Functionally Important Regions in H1N1 Influenza Proteome

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Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue in vitro by Modified Vaccinia Ankara-vectored influenza vaccines

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Influenza Virus Specific CD8+T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice

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Adaptive evolution during the establishment of European avian‐like H 1 N 1 influenza A virus in swine

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Bioengineering a highly productive vaccine strain in embryonated chicken eggs and mammals from a non-pathogenic clade 2·3·4·4 H5N8 strain

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Targeting Viral Surface Proteins through Structure-Based Design

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Screening of Random Peptide Library of Hemagglutinin from Pandemic 2009 A(H1N1) Influenza Virus Reveals Unexpected Antigenically Important Regions

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Mimotope ELISA for Detection of Broad Spectrum Antibody against Avian H5N1 Influenza Virus

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Isolation of Panels of Llama Single-Domain Antibody Fragments Binding All Nine Neuraminidase Subtypes of Influenza A Virus

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Conserved stem fragment from H3 influenza hemagglutinin elicits cross-clade neutralizing antibodies through stalk-targeted blocking of conformational change during membrane fusion

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Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

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Designed nanoparticles elicit cross-reactive antibody responses to conserved influenza virus hemagglutinin stem epitopes

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Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem

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Polyclonal and Monoclonal Antibodies for the Treatment and Prevention of Influenza

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Addressing Viral Resistance Through Vaccines

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Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells

Cox, F., Baart, M., Huizingh, J., Tolboom, J. T. B. M., Dekking, L., Goudsmit, J., Saeland, E., & Radošević, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145243 · Cited by 15

Display Technologies for the Selection of Monoclonal Antibodies for Clinical Use

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Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies

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COVID-19 Epidemic Analysis and Prediction Using Machine Learning Algorithms

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Transient Humoral Protection against H5N1 Challenge after Seasonal Influenza Vaccination of Humans

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Association between Hemagglutinin Stem-Reactive Antibodies and Influenza A/H1N1 Virus Infection during the 2009 Pandemic

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Mapping Antibody Epitopes of the Avian H5N1 Influenza Virus

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Does exposure to poultry and wild fowl confer immunity to H5N1?

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Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem

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Properties and Therapeutic Efficacy of Broadly Reactive Chimeric and Humanized H5-Specific Monoclonal Antibodies against H5N1 Influenza Viruses

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Multi-responsive hybrid Janus nanoparticles: Surface functionalization through solvent physisorption

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Influenza virus A(H1N1)2009 antibody-dependent cellular cytotoxicity in young children prior to the H1N1 pandemic

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Repertoire and Neutralizing Activity of Antibodies Against Hepatitis C Virus E2 Peptide in Patients With Spontaneous Resolution of Hepatitis C

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Autoreactivity of Broadly Neutralizing Influenza Human Antibodies to Human Tissues and Human Proteins

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Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

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Cyanovirin-N Binds Viral Envelope Proteins at the Low-Affinity Carbohydrate Binding Site without Direct Virus Neutralization Ability

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Pseudotyped Viruses for Influenza

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Influenza pharmacotherapy: present situation, strategies and hopes

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Two Types of Antibodies Are Induced by Vaccination with A/California/2009pdm Virus: Binding near the Sialic Acid-Binding Pocket and Neutralizing Both H1N1 and H5N1 Viruses

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Combining spatial and chemical information for clustering pharmacophores

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Coverage of Related Pathogenic Species by Multivalent and Cross-Protective Vaccine Design: Arenaviruses as a Model System

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Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

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Immunogenicity and Immunodominance in Antibody Responses

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Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it

Wang, W., Vassell, R. A., Song, H. S., Qiong, C., Keller, P. W., Verma, S., Alvarado-Facundo, E., Wan, H., Schmeisser, F., Meseda, C. A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222436 · Cited by 12

Different mechanisms of the protection against influenza A infection mediated by broadly reactive HA2-specific antibodies

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Effect of an Adenovirus-Vectored Universal Influenza Virus Vaccine on Pulmonary Pathophysiology in a Mouse Model

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Site-Specific Glycan-Masking/Unmasking Hemagglutinin Antigen Design to Elicit Broadly Neutralizing and Stem-Binding Antibodies Against Highly Pathogenic Avian Influenza H5N1 Virus Infections

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Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies

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Investigating Substitutions in Antibody–Antigen Complexes Using Molecular Dynamics: A Case Study with Broad-spectrum, Influenza A Antibodies

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Peptides Derived from Glycoproteins H and B of Herpes Simplex Virus Type 1 and Herpes Simplex Virus Type 2 Are Capable of Blocking Herpetic Infection in vitro

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Inhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses

Moon, H.-J., Nikapitiya, C., Lee, H., Park, M.-E., Kim, J., Kim, T.-H., Yoon, J., Cho, W., Yeul, J., Kim, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04777-4 · Cited by 12

Heterosubtypic cross-reactivity of HA1 antibodies to influenza A, with emphasis on nonhuman subtypes (H5N1, H7N7, H9N2)

Beest, D. E. T., de Bruin, E., Imholz, S., Koopmans, M., & van Boven, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181093 · Cited by 12

5th European Antibody Congress 2009

Beck, A., Reichert, J. M., & Wurch, T. (2010) · mAbs · doi:10.4161/mabs.2.2.11302 · Cited by 12

Influenza glycoproteins: Hemagglutinin and neuraminidase

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From Computational Design to a Protein That Binds

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Robust de novo design of protein binding proteins from target structural information alonePreprint

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., Verstraete, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.04.459002 · Cited by 12

Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes

Lin, T.-H., Lee, C.-C. D., Fernández‐Quintero, M. L., Ferguson, J. A., Han, J., Zhu, X., Yu, W., Guthmiller, J. J., Krammer, F., Wilson, P. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56496-4 · Cited by 12

Large-Scale Analysis of B-Cell Epitopes on Influenza Virus Hemagglutinin – Implications for Cross-Reactivity of Neutralizing Antibodies

Sun, J., Kudahl, U. J., Simon, C., Cao, Z., Reinherz, E. L., & Brusić, V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00038 · Cited by 11

Broadly neutralizing antibodies for therapy of viral infections

Varadarajan, R., Srinivasan, S., Maity, S., & Ghosh, M. (2016) · Antibody Technology Journal · doi:10.2147/anti.s92190 · Cited by 11

Influenza vaccines: ‘tailor-made’ or ‘one fits all’

Saletti, G., Gerlach, T. H., & Rimmelzwaan, G. F. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.04.015 · Cited by 11

Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient

Li, J., Yang, Y., Wang, M., Ren, X., Yang, Z., Liu, L., Zhang, G., Chen, Q., Yang, W. Z., Chen, Y. H., et al. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.104564 · Cited by 11

Normal modes analysis and surface electrostatics of haemagglutinin proteins as fingerprints for high pathogenic type A influenza viruses

Righetto, I., & Filippini, F. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03563-w · Cited by 11

Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic Escherichia coli

Liu, Y., Shahabudin, S., Farid, S., Lee, L. H., McVeigh, A. L., Maciel, M., Poole, S., Broadman, M., Prouty, M. G., & Savarino, S. J. (2020) · Infection and Immunity · doi:10.1128/iai.00246-20 · Cited by 11

Retracted and republished from: “The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs”

Li, Y., Huo, S., Yin, Z., Tian, Z., Huang, F., Liu, P., Liu, Y., & Yu, F. (2024) · mBio · doi:10.1128/mbio.00175-24 · Cited by 11

High-resolution genetic profile of viral genomes: why it matters

Qi, H., Wu, N. C., Du, Y., Wu, T.-T., & Sun, R. (2015) · Current Opinion in Virology · doi:10.1016/j.coviro.2015.08.005 · Cited by 11

Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A

Zhong, Y., Cai, J., Zhang, C., Xing, X., Qin, E., He, J., Mao, P., Cheng, J., Liu, K., Xu, D., et al. (2011) · Virology Journal · doi:10.1186/1743-422x-8-542 · Cited by 11

In vitro and in vivo characterization of designed immunogens derived from the CD-helix of the stem of influenza hemagglutinin

Mallajosyula, V. V. A., Citron, M. P., Lu, X., ter Meulen, J., Varadarajan, R., & Liang, X. (2013) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24317 · Cited by 11

Divergent Requirement of Fc-Fcγ Receptor Interactions for In Vivo Protection against Influenza Viruses by Two Pan-H5 Hemagglutinin Antibodies

Wang, S., Ren, H., Jiang, W., Chen, H., Hu, H., Chen, Z., & Zhou, P. (2017) · Journal of Virology · doi:10.1128/jvi.02065-16 · Cited by 11

Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7 subtype viruses?

Stadlbauer, D., Nachbagauer, R., Meade, P. S., & Krammer, F. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0602-z · Cited by 11

Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses

Liu, J., Ren, Z., Wang, H., Zhao, Y., Wilker, P. R., Yu, Z., Sun, W., Wang, T., Feng, N., Li, Y., et al. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.07.011 · Cited by 11

Structural Insights for Anti-Influenza Vaccine Design

Han, L., Chen, C., Han, X., Lin, S., Han, X., Han, X., Wang, J., & Ye, H. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.03.009 · Cited by 11

A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity

Trost, J. F., Wang, W., Liang, B., Galloway, S. E., Agbogu, E., Byrd-Leotis, L. A., & Steinhauer, D. A. (2019) · Virology · doi:10.1016/j.virol.2019.08.005 · Cited by 11

Identification of a moderate affinity CD22 binding peptide and in vitro optimization of peptide-targeted nanoparticles for selective uptake by CD22+ B-cell malignancies

Kim, B., Shin, J.-H., Kiziltepe, T., & Bilgiçer, B. (2020) · Nanoscale · doi:10.1039/d0nr02133d · Cited by 11

A panel of anti-influenza virus nucleoprotein antibodies selected from phage-displayed synthetic antibody libraries with rapid diagnostic capability to distinguish diverse influenza virus subtypes

Yu, C.-M., Chen, I.-C., Tung, C.-P., Peng, H., Jian, J.-W., Chiu, Y.-K., Tsou, Y.-L., Chen, H., Huang, Y., Hsiao, W. W., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70135-6 · Cited by 11

Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy

Yep, A. T., Takeuchi, Y., Engelhardt, O. G., & Hufton, S. E. (2021) · Biomolecules · doi:10.3390/biom11030407 · Cited by 12

Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region

Pascha, M. N., Thijssen, V., Egido, J. E., Linthorst, M. W., van Lanen, J. H., van Dongen, D. A. A., Hopstaken, A. J. P., van Kuppeveld, F. J. M., Snijder, J., de Haan, C. A. M., et al. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00040 · Cited by 11

Comparison of vaccination efficacy using live or ultraviolet-inactivated influenza viruses introduced by different routes in a mouse model

Baek, K., Maharjan, S., Akauliya, M., Thapa, B., Kim, D., Kim, J., Kim, M., Kang, M., Kim, S., Bae, J., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275722 · Cited by 11

Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge

Cox, F., Roos, A., Hafkemeijer, N., Baart, M., Tolboom, J. T. B. M., Dekking, L., Stittelaar, K. J., Goudsmit, J., Radošević, K., & Saeland, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135723 · Cited by 11

Que sera, sera: evolution of the swine H1N1 influenza A virus

Hensley, S. E., & Yewdell, J. W. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.62 · Cited by 11

Evaluation of Diagnostic Applications of Monoclonal Antibodies against Avian Influenza H7 Viruses

Yang, M., Clavijo, A., Graham, J., Pasick, J. M. M., Neufeld, J., & Berhane, Y. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00023-10 · Cited by 11

Complete Protection against Influenza Virus H1N1 Strain A/PR/8/34 Challenge in Mice Immunized with Non-Adjuvanted Novirhabdovirus Vaccines

Rouxel, R. N., Mérour, E., Biacchesi, S., & Brémont, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164245 · Cited by 11

An Epitope of Bacillus anthracis Protective Antigen That Is Cryptic in Rabbits May Be Immunodominant in Humans

Ingram, R. J., Chu, K. K., Metan, G., Maillère, B., Doğanay, M., Özkul, Y., Dyson, H., Williamson, E. D., Baillie, L. W. J., Kim, L. U., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00072-10 · Cited by 11

Designing epitope-focused vaccines via antigen reorientationPreprint

Xu, D., Li, C., Utz, A., Weidenbacher, P. A. B., Tang, S., Sanyal, M., Pulendran, B., & Kim, P. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.20.521291 · Cited by 11

Directed selection of amino acid changes in the influenza hemagglutinin and neuraminidase affecting protein antigenicity

DeDiego, M. L., Chiem, K., & Topham, D. J. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.09.005 · Cited by 10

In silico epitope-based vaccine design against influenza a neuraminidase protein: Computational analysis established on B- and T-cell epitope predictions

Almalki, S. S. R., Beigh, S., Akhter, N., & Alharbi, R. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.103283 · Cited by 10

Antigenic Landscape Analysis of Individuals Vaccinated with a Universal Influenza Virus Vaccine Candidate Reveals Induction of Cross-Subtype Immunity

Meade, P. S., Strohmeier, S., Bermúdez-González, M. C., García‐Sastre, A., Palese, P., Simon, V. R., & Krammer, F. (2022) · Journal of Virology · doi:10.1128/jvi.01070-22 · Cited by 10

Molecular Modeling of Viral Type I Fusion Proteins: Inhibitors of Influenza Virus Hemagglutinin and the Spike Protein of Coronavirus

Borisevich, S. S., Zarubaev, V. V., Щербаков, Д. Н., Yarovaya, О. I., & Salakhutdinov, N. F. (2023) · Viruses · doi:10.3390/v15040902 · Cited by 10

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Yang, Y. R., Han, J., Perrett, H. R., Richey, S. T., Rodriguez, A. J., Jackson, A. M., Gillespie, R. A., O’Connell, S. E., Raab, J. E., Cominsky, L. Y., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114171 · Cited by 10

Public antibodies: convergent signatures in human humoral immunity against pathogens

Rao, V. N., & Coelho, C. H. (2025) · mBio · doi:10.1128/mbio.02247-24 · Cited by 10

Guided design for the development of an evolution-proof influenza vaccine

Myburgh, L., van Loon, K., Huijbers, E. J. M., B, J. R. V. B., Russell, C. A., & Griffioen, A. W. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127281 · Cited by 11

LEAPS Therapeutic Vaccines as Antigen Specific Suppressors of Inflammation in Infectious and Autoimmune Diseases

Zimmerman, D. H. (2012) · Journal of Vaccines & Vaccination · doi:10.4172/2157-7560.1000149 · Cited by 10

Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite

Cheung, C. S., Gorman, J., Andrews, S. F., Rawi, R., Reveiz, M., Shen, C., Wang, Y., Harris, D. R., Nazzari, A. F., Olia, A. S., et al. (2022) · Structure · doi:10.1016/j.str.2022.04.003 · Cited by 10

A novel neutralizing antibody against diverse clades of H5N1 influenza virus and its mutants capable of airborne transmission

Wu, R., Li, X., Leung, H.-C., Cao, Z., Qiu, Z., Zhou, Y., Zheng, B., & He, Y. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2014.03.005 · Cited by 10

Monoclonal antibodies for prophylactic and therapeutic use against viral infections

Both, L., Banyard, A. C., van Dolleweerd, C. J., Wright, E., K‐C., J., & Fooks, A. R. (2013) · Pediatria Polska · doi:10.1016/j.pepo.2013.08.006 · Cited by 10

Structural analysis of the hot spots in the binding between H1N1 HA and the 2D1 antibody: do mutations of H1N1 from 1918 to 2009 affect much on this binding?

Liu, Q., Hoi, S. C. H., Su, C. T.-T., Li, Z., Kwoh, C.-K., Wong, L., & Li, J. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr437 · Cited by 10

Refining the Approach to Vaccines Against Influenza a Viruses with Pandemic Potential

Czakó, R., & Subbarao, K. (2015) · Future Virology · doi:10.2217/fvl.15.69 · Cited by 10

Toward universal influenza virus vaccines: from natural infection to vaccination strategy

Zhao, C., & Xu, J. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.020 · Cited by 10

Three Types of Broadly Reacting Antibodies against Influenza B Viruses Induced by Vaccination with Seasonal Influenza Viruses

Hirano, D., Ohshima, N., Kubota‐Koketsu, R., Yamasaki, A., Kurosawa, G., Okuno, Y., Yoshida, S., & Kurosawa, Y. (2018) · Journal of Immunology Research · doi:10.1155/2018/7251793 · Cited by 10

A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., Wang, F., Zhou, F., Wang, G., Tsai, C., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06665-11 · Cited by 72

Research highlights

(2009) · Nature Biotechnology · doi:10.1038/nbt0409-348

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M. A. C., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 820

A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

(2016)

An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Lee, C., Yang, C.-Y., Lin, L., Ko, T., Chang, A., Chang, S. S.-C., & Wang, A. H. ‐. (2019) · Scientific Reports · doi:10.1038/s41598-019-40937-4 · Cited by 22