The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Open accessAbstract
Neurogenesis and Spatial Memory: The dentate gyrus of the hippocampus is one of two sites in the brain where new neurons are produced throughout life. Adult-born neurons integrate into the dentate gyrus circuitry and are thought to play a role in learning and memory. However, their contribution to hippocampal function remains unclear. Clelland et al. (p. 210 ) disrupted neurogenesis in mice and used two behavioral tasks to test for impairment in the formation of uncorrelated episodic memory representations. In one task, two arms were presented and the mice were rewarded for choosing the most recently visited arm in an earlier sequence; in the second task, animals were rewarded for choosing a certain location on a touch screen. Ablation of neurogenesis affected discrimination performance in both tasks but only when the arms or screen locations were close to one another. Neurogenesis is thus necessary for spatial pattern separation in the dentate gyrus.
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“Although unknown in humans, studies in adult rodents have demonstrated that new born neurons have a critical period (2-4 weeks) of hyperexcitability, when they are preferentially recruited during a wide variety of hippocampal-dependent tasks such as flexible learning113, 114, spatial memory115 and most notably pattern separation (the ability to separate similar but different memories or”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [115]
In the citing paper
“Furthermore, new neurons, presumably through their unique electrophysiological properties and sparse connections to CA3 neurons (Amaral et al., 2007), have been found to participate in pattern separation (Clelland et al., 2009; Danielson et al., 2016; Sahay et al., 2011), the process of making similar neural inputs distinct.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Clelland et al., 2009
In the citing paper
“Elimination or optogenetic silencing of adult-born neurons impairs pattern separation-like behaviors (Clelland et al., 2009; Danielson et al., 2016), while transgenic increases in adult neurogenesis enhance the ability of mice to distinguish between highly similar contexts (Sahay et al., 2011).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Clelland et al., 2009
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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
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Mechanisms and Functional Implications of Adult Neurogenesis
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Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
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Self-citationFunctional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Self-citationSimple memory: a theory for archicortex
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Learning enhances adult neurogenesis in the hippocampal formation
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Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
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Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,544
Self-citationPattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
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A role for adult neurogenesis in spatial long-term memory
Snyder, J. S., Hong, N. S., McDonald, R. J., & Wojtowicz, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.009 · Cited by 854
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Metadata
- Authors
- Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., & Bussey, T. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of Cambridge (GB)
- ETH Zurich (CH)
- Corresponding author
- Barker, R. A.
- Gage, F. H.
- Bussey, T. J.
- ORCID
- Venue
- Science
- Published
- 2009-07-10
- Volume
- 325
- Issue
- 5937
- Pages
- 210-213
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2997634
- OpenAlex
- W2051173215
- Cited by
- 1,642
- References
- 30
- Citations by year
- 2026: 44 · 2025: 62 · 2024: 65 · 2023: 68 · 2022: 93 · 2021: 105 · 2020: 106 · 2019: 87 · 2018: 95 · 2017: 124 · 2016: 106 · 2015: 127 · 2014: 131 · 2013: 120 · 2012: 101
- FWCI
- 32.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS050217, NS050217)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult hippocampal neurogenesis, spatial pattern separation, dentate gyrus, spatial discrimination, radial maze, spatial memory, newborn neurons, hippocampal function
- MeSH terms
- Animals, Cues, Discrimination Learning, Female, Hippocampus, Memory, Mice, Inbred C57BL, Neurons, Psychomotor Performance, Space Perception, Maze Learning, Dentate Gyrus, Mice, Neurogenesis
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