The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Open accessAbstract
Neurogenesis and Spatial Memory: The dentate gyrus of the hippocampus is one of two sites in the brain where new neurons are produced throughout life. Adult-born neurons integrate into the dentate gyrus circuitry and are thought to play a role in learning and memory. However, their contribution to hippocampal function remains unclear. Clelland et al. (p. 210 ) disrupted neurogenesis in mice and used two behavioral tasks to test for impairment in the formation of uncorrelated episodic memory representations. In one task, two arms were presented and the mice were rewarded for choosing the most recently visited arm in an earlier sequence; in the second task, animals were rewarded for choosing a certain location on a touch screen. Ablation of neurogenesis affected discrimination performance in both tasks but only when the arms or screen locations were close to one another. Neurogenesis is thus necessary for spatial pattern separation in the dentate gyrus.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, new neurons, presumably through their unique electrophysiological properties and sparse connections to CA3 neurons (Amaral et al., 2007), have been found to participate in pattern separation (Clelland et al., 2009; Danielson et al., 2016; Sahay et al., 2011), the process of making similar neural inputs distinct.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Clelland et al., 2009
In the citing paper
“Although unknown in humans, studies in adult rodents have demonstrated that new born neurons have a critical period (2-4 weeks) of hyperexcitability, when they are preferentially recruited during a wide variety of hippocampal-dependent tasks such as flexible learning113, 114, spatial memory115 and most notably pattern separation (the ability to separate similar but different memories or”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [115]
In the citing paper
“Elimination or optogenetic silencing of adult-born neurons impairs pattern separation-like behaviors (Clelland et al., 2009; Danielson et al., 2016), while transgenic increases in adult neurogenesis enhance the ability of mice to distinguish between highly similar contexts (Sahay et al., 2011).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Clelland et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Self-citationFunctional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Self-citationSimple memory: a theory for archicortex
Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601
Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,544
Self-citationPattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
Bakker, A., Kirwan, C. B., Miller, M. I., & Stark, C. E. L. (2008) · Science · doi:10.1126/science.1152882 · Cited by 1,050
A role for adult neurogenesis in spatial long-term memory
Snyder, J. S., Hong, N. S., McDonald, R. J., & Wojtowicz, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.009 · Cited by 854
Spatial selectivity of unit activity in the hippocampal granular layer
Jung, M. W., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030209 · Cited by 789
Hippocampal remapping and grid realignment in entorhinal cortex
Fyhn, M., Hafting, T., Treves, A., Moser, M.-B., & Moser, E. I. (2007) · Nature · doi:10.1038/nature05601 · Cited by 749
Neurons born in the adult dentate gyrus form functional synapses with target cells
Toni, N., Laplagne, D. A., Zhao, C., Lombardi, G., Ribak, C. E., Gage, F. H., & Schinder, A. F. (2008) · Nature Neuroscience · doi:10.1038/nn.2156 · Cited by 741
Self-citationJessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654
Self-citationDissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641
Chapter 1 Chapter Neurons, numbers and the hippocampal network
Amaral, D. G., Ishizuka, N., & Claiborne, B. J. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61237-6 · Cited by 523
A role for adult TLX-positive neural stem cells in learning and behaviour
Zhang, C., Zou, Y., He, W., Gage, F. H., & Evans, R. M. (2008) · Nature · doi:10.1038/nature06562 · Cited by 523
Self-citationTransgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L., & Tonegawa, S. (2008) · Science · doi:10.1126/science.1151120 · Cited by 492
Vazdarjanova, A., & Guzowski, J. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0350-04.2004 · Cited by 465
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458
Computational Influence of Adult Neurogenesis on Memory Encoding
Aimone, J. B., Wiles, J., & Gage, F. H. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.026 · Cited by 382
Self-citationAdult‐born hippocampal neurons mature into activity‐dependent responsiveness
Jessberger, S., & Kempermann, G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.02986.x · Cited by 326
Self-citationMemory for Spatial Location: Role of the Hippocampus in Mediating Spatial Pattern Separation
Gilbert, P. E., Kesner, R. P., & DeCoteau, W. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00804.1998 · Cited by 193
The effects of running and of inhibiting adult neurogenesis on learning and memory in rats.
Wojtowicz, J. M., Askew, M. L., & Winocur, G. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06128.x · Cited by 158
Gilbert, P. E., & Kesner, R. P. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1385 · Cited by 153
Hunsaker, M. R., & Kesner, R. P. (2008) · Hippocampus · doi:10.1002/hipo.20455 · Cited by 133
Talpos, J. C., Winters, B. D., Dias, R. S., Saksida, L. M., & Bussey, T. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1526-3 · Cited by 122
Self-citationA new touchscreen test of pattern separation: effect of hippocampal lesions
McTighe, S. M., Mar, A. C., Romberg, C., Bussey, T. J., & Saksida, L. M. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832c5eb2 · Cited by 106
Self-citationMeasuring cognitive deficits in disabled mice using an automated interactive touchscreen system
Morton, A. J., Skillings, E. A., Bussey, T. J., & Saksida, L. M. (2006) · Nature Methods · doi:10.1038/nmeth1006-767 · Cited by 85
Self-citationRadial maze performance in young and aged mice: Neurochemical correlates
Bernstein, D., Olton, D. S., Ingram, D. K., Waller, S. B., Reynolds, M. A., & London, E. D. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90395-8 · Cited by 56
Research works printed but not linked: 1
- 10.1126/science.1114037 · DOI
Cited by
Sorted by citations
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
Self-citationDynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Pattern separation in the hippocampus
Yassa, M. A., & Stark, C. E. L. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.006 · Cited by 1,544
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122
Self-citation
Metadata
- Authors
- Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., & Bussey, T. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of Cambridge (GB)
- ETH Zurich (CH)
- Corresponding author
- Barker, R. A.
- Gage, F. H.
- Bussey, T. J.
- ORCID
- Venue
- Science
- Published
- 2009-07-10
- Volume
- 325
- Issue
- 5937
- Pages
- 210-213
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2997634
- OpenAlex
- W2051173215
- Cited by
- 1,642
- References
- 30
- Citations by year
- 2026: 44 · 2025: 62 · 2024: 65 · 2023: 68 · 2022: 93 · 2021: 105 · 2020: 106 · 2019: 87 · 2018: 95 · 2017: 124 · 2016: 106 · 2015: 127 · 2014: 131 · 2013: 120 · 2012: 101
- FWCI
- 32.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS050217, NS050217)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult hippocampal neurogenesis, spatial pattern separation, dentate gyrus, spatial discrimination, radial maze, spatial memory, newborn neurons, hippocampal function
- MeSH terms
- Animals, Cues, Discrimination Learning, Female, Hippocampus, Memory, Mice, Inbred C57BL, Neurons, Psychomotor Performance, Space Perception, Maze Learning, Dentate Gyrus, Mice, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
