Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum
Abstract
In the adult central nervous system (CNS) subsets of neurons are enwrapped by densely organized extracellular matrix structures, called perineuronal nets (PNNs). PNNs are formed at the end of critical periods and contribute to synapse stabilization. Enzymatic degradation of PNNs or genetic deletion of specific PNN components leads to the prolongation of the plasticity period. PNNs consist of extracellular matrix molecules, including chondroitin sulfate proteoglycans, hyaluronan, tenascins and link proteins. It has been recently shown that the chemorepulsive axon guidance protein semaphorin3A (Sema3A) is also a constituent of PNNs, binding with high affinity to the sugar chains of chondroitin sulfate proteoglycans. To elucidate whether the expression of Sema3A is modified in parallel with structural plasticity in the adult CNS, we examined Sema3A expression in the deep cerebellar nuclei of the adult mouse in a number of conditions associated with structural reorganization of the local connectivity. We found that Sema3A in PNNs is reduced during enhanced neuritic remodeling, in both physiological and injury-induced conditions. Moreover, we provide evidence that Sema3A is tightly associated with Purkinje axons and their terminals and its amount in the PNNs is related to Purkinje cell innervation of DCN neurons, but not to glutamatergic inputs. On the whole these data suggest that Sema3A may contribute to the growth-inhibitory properties of PNNs and Purkinje neurons may directly control their specific connection pattern through the release and capture of this guidance cue in the specialized ECM that surrounds their terminals.
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Partial deprivation of cerebellar nuclei neurons of their main GABAergic inputs, the Purkinje cells, results in a strong decrease of PNNs and their content of Sema3A in denervated regions.
“Partial deprivation of cerebellar nuclei neurons of their main GABAergic inputs, the Purkinje cells results in a strong decrease of PNNs and their content of Sema3A in denervated regions (Carulli et al., 2013).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Carulli et al., 2013
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- Authors
- Carulli, D., Foscarin, S., Faralli, A., Pajaj, E., & Rossi, F.
- Affiliations
- Neuroscience Institute Cavalieri Ottolenghi (IT)
- Corresponding author
- Carulli, Daniela
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 57
- Pages
- 10-22
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2100592333
- Cited by
- 59
- References
- 68
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 10 · 2017: 4 · 2016: 7 · 2015: 11 · 2014: 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- semaphorin 3A, perineuronal nets, deep cerebellar nuclei, structural plasticity, Purkinje cells, axon guidance, extracellular matrix, chondroitin sulfate proteoglycans, synapse stabilization
- MeSH terms
- Animals, Cerebellum, Extracellular Matrix, Purkinje Cells, Semaphorin-3A, Mice
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