Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

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Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits

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Histone deacetylase inhibition inhibits brachial plexus avulsion‐induced neuropathic pain

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Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling

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Vitamin B12-folic acid supplementation regulates neuronal immediate early gene expression and improves hippocampal dendritic arborization and memory in old male mice

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Age‐related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L‐type calcium channel, CaV1 .3

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Is CREB the Angry Bird that Releases Memory in Alzheimer's?

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H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex

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Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory

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Epigenetic mechanisms in Alzheimer's disease

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HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer's disease

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Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus

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Targeting neuronal epigenomes for brain rejuvenation

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A HAT for sleep?

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Histone Modification Changes During Aging

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Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway

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Epigenetics and the human brain: Where nurture meets nature

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Aging and perioperative brain health: Mechanisms, management, and future

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A crucial role for dynamic expression of components encoding the negative arm of the circadian clock

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Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function

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Dysregulated expression of cholesterol biosynthetic genes in Alzheimer's disease alters epigenomic signatures of hippocampal neurons

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Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases

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Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish

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Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae

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‘Relax and Repair’ to restrain aging

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CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging

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Characterization of a Novel Chromatin Sorting Tool Reveals Importance of Histone Variant H3.3 in Contextual Fear Memory and Motor Learning

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Postnatal Isoflurane Exposure Induces Cognitive Impairment and Abnormal Histone Acetylation of Glutamatergic Systems in the Hippocampus of Adolescent Rats

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Changes in DNA methylation over the growing season differ between North Carolina farmworkers and non-farmworkers

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Epigenetics, Brain and Behavior

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BV2-derived extracellular vesicles modulate microglia inflammatory profile, neuronal plasticity, and behavioural performances in late adult mice.

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Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration

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Human neuronal cells: epigenetic aspects

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Stimulation of the Serotonin Receptor 7 Restores Brain Histone H3 Acetylation and MeCP2 Corepressor Protein Levels in a Female Mouse Model of Rett Syndrome

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Treadmill exercise alters histone acetylation differently in rats exposed or not exposed to aversive learning context

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Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation

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Epigenetic Alterations Impact on Antipsychotic Treatment in Elderly Patients

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Histone tail acetylation in brain occurs in an unpredictable fashion after death

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Epigenetic Modification and Its Role in Alzheimer's Disease

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Visual experience dependent regulation of neuronal structure and function by histone deacetylase 1 in developing Xenopus tectum in vivo

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Design (Docking and QSAR Studies) and synthesis of histone deacetylase 2 (HDAC2) inhibitors series

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Overview of trends in global epigenetic research (2009–2017)

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Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease micePreprint

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Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond

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Modulating Cognition-Linked Histone Acetyltransferases (HATs) as a Therapeutic Strategy for Neurodegenerative Diseases: Recent Advances and Future Trends

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Histone modifications: Key players in Alzheimer's disease

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Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment

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Class I HDAC inhibition improves object recognition memory consolidation through BDNF/TrkB pathway in a time-dependent manner

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Class 1 histone deacetylases differentially modulate memory and synaptic genes in a spatial and temporal manner in aged and APP/PS1 mice

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Epigenetic processes in Alzheimer's disease

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Activity‐Dependent Induction of Younger Biological Phenotypes

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Histone Post-translational Modifications to Target Memory-related Diseases

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Learning induced epigenetic modifications in the ventral striatum are necessary for long-term memory

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Proteoform characterization based on top-down mass spectrometry

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Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice

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Epigenetic histone modifications in kidney disease and epigenetic memory

Sasaki, K., & Masaki, T. (2025) · Clinical and Experimental Nephrology · doi:10.1007/s10157-025-02668-x · Cited by 8

Reprogramming—Evolving Path to Functional Surrogate β-Cells

Kalo, E., Read, S. A., & Ahlenstiel, G. (2022) · Cells · doi:10.3390/cells11182813 · Cited by 8

Modulation of Synaptic Plasticity Genes Associated to DNA Damage in a Model of Huntington’s Disease

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Pharmacological inhibition of histone deacetylases ameliorates cognitive impairment after intracerebral hemorrhage with epigenetic alteration in the hippocampus

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Cognitive Dysfunction and Exercise: From Epigenetic to Genetic Molecular Mechanisms

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Mitochondrial stress-induced H4K12 hyperacetylation dysregulates transcription in Parkinson’s disease

Huang, M., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1422362 · Cited by 9

Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction

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Molecular Mechanisms of Learning and Memory**The authors declare no competing financial interests.

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The Role of Dynamic Histone Modifications in Learning Behavior

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Aβ42 Expressing Drosophila melanogaster Model for Alzheimer's Disease: Quantitative Proteomics Identifies Altered Protein Dynamics of Relevance to Neurodegeneration

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The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice

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A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

Cohen‐Armon, M. (2022) · Cells · doi:10.3390/cells11091576 · Cited by 8

Histone Modifications in Neurological Disorders

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Valproic acid-mediated inhibition of trimethyltin-induced deficits in memory and learning in the rat does not directly depend on its anti-oxidant properties

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Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms

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Recovery of Age-Related Memory Loss: Hopes and Challenges

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The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review

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The dynamic transcriptomic response of the goldfish brain under chronic hypoxia

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Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress

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Learning depends on the information conveyed by temporal relationships between events and is reflected in the dopamine response to cues

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Histone Deacetylation in Alzheimer’s Diseases (AD); Hope or Hype

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Hypothesis: epigenetic effects will require a review of the genetics of child development

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Working memory training triggers delayed chromatin remodeling in the mouse corticostriatothalamic circuit

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Specific de-SUMOylation triggered by acquisition of spatial learning is related to epigenetic changes in the rat hippocampus

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Histone Modifications in the Nervous System and Neuropsychiatric Disorders

Bridi, M. S., & Abel, T. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00002-1 · Cited by 8

The Distinctive Role of NREM and REM Sleep in the Consolidation of Fear Memory

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Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge

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HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI

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The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice

Nicolay-Kritter, K., Lassalle, J., Guillou, J., & Mons, N. E. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107406 · Cited by 6

Increased histone acetylation levels or a serotonin precursor reinstate the context memory impaired by the serotonin receptor blocker methiothepin

Zuzina, A. B., & Vinarskaya, A. K. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01303-6 · Cited by 7

HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer’s Disease

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Innovative approaches in cognitive aging

Austad, S. N., Wood, M. A., Villeda, S., Voss, J. L., Sahay, A., & Albert, M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.04.013 · Cited by 9

Epigenetic Modulation of Gene Expression by Exercise

Goto, S., Kawakami, K., Naito, H., Katamoto, S., & Radák, Z. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-14830-4_5 · Cited by 4

New Insight in The Molecular Mechanisms of Neurodegenerative Disease

Meiliana, A., Dewi, N. M., & Wijaya, A. (2018) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v10i1.448 · Cited by 6

Normal Neurocognitive Aging

Fletcher, B. R., & Rapp, P. R. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop203024 · Cited by 8

Science

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Altered Histone 4 K12 Acetylation is Associated with Age Dependent Memory Impairment in Mice

Peleg, S. (2010) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3189

Inhibition of histone lysine demethylase restores learning and memory in aged micePreprint

Bhatt, S. R., MacBean, L. F., Kramár, E. A., Pérez‐Sisqués, L., Smethurst, P., Robb, J. L., Jindal, N., Fetterly, T. L., Graham, A., Wood, M. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.695858

Alterations of Histone Acetylation Associated with Cognitive Decline in Mouse Brain During Aging: Genome-Wide Epigenetic AnalysisPreprint

Scheinman, S. B., Carvill, G. L., & Dong, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5045299

Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

Morse, S. J., Butler, A. A., Davis, R. L., Soller, I., & Lubin, F. D. (2015) · Biology · doi:10.3390/biology4020298 · Cited by 81