Cited by 951Memory and Neural MechanismsGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Peleg, Shahaf, Sananbenesi, Farahnaz, Zovoilis, Athanasios, Burkhardt, Susanne, Bahari-Javan, Sanaz, Agis-Balboa, Roberto Carlos, Cota, Perla, Wittnam, Jessica Lee, Gogol-Doering, Andreas, Opitz, Lennart, Salinas-Riester, Gabriella, Dettenhofer, Markus, Kang, Hui, Farinelli, Laurent, Chen, Wei, Fischer, André·2010·Science

DOI 10.1126/science.1186088

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Abstract

As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain.

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Authors: Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., Salinas-Riester, G., Dettenhofer, M., Kang, H., Farinelli, L., Chen, W., & Fischer, A.
Affiliations: European Neuroscience Institute Göttingen (DE)
Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str. 5, D-37077 Goettingen, Germany.
Max Delbrueck Center for Molecular Medicine, Institute for Medical Systems Biology, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.
University of Göttingen (DE)
Harvard University (US)
Max Delbrück Center (DE)
Fasteris SA, CH-1228 Plan-les-Ouates, Switzerland.
Corresponding author: Peleg, Shahaf
Sananbenesi, Farahnaz
Zovoilis, Athanasios
Fischer, André
ORCID: Peleg, Shahaf
Sananbenesi, Farahnaz
Zovoilis, Athanasios
Opitz, Lennart
Dettenhofer, Markus
Kang, Hui
Chen, Wei
Fischer, André
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-05-07
Volume: 328
Issue: 5979
Pages: 753-756
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1186088
OpenAlex: W2149591661
Cited by: 951
References: 24
Citations by year: 2026: 16 · 2025: 30 · 2024: 51 · 2023: 38 · 2022: 42 · 2021: 50 · 2020: 52 · 2019: 50 · 2018: 60 · 2017: 60 · 2016: 81 · 2015: 77 · 2014: 76 · 2013: 94 · 2012: 73
FWCI: 51.84
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
GRO (submittedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: histone acetylation, H4K12 acetylation, hippocampus, chromatin plasticity, memory consolidation, cognitive decline, brain aging, biomarkers, gene-environment interaction
MeSH terms: Formins, Acetylation, Aging, Animals, Chromatin, Conditioning, Psychological, Fear, Gene Expression Regulation, Hippocampus, Histones, Hydroxamic Acids, Learning, Lysine, Memory, Memory Disorders, Mice, Inbred C57BL, Microfilament Proteins, Nerve Tissue Proteins, Nuclear Proteins, Transcription, Genetic, Signal Transduction, Up-Regulation, Gene Expression Profiling, Transcription Initiation Site, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Histone Deacetylase Inhibitors

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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

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