Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

Combinatorial patterns of histone acetylations and methylations in the human genome

Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298

Gene regulation and DNA damage in the ageing human brain

Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644

ChIP-seq accurately predicts tissue-specific activity of enhancers

Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature · doi:10.1038/nature07730 · Cited by 1,639

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473

Recovery of learning and memory is associated with chromatin remodelling

Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227

Regulation of histone acetylation during memory formation in the hippocampus

Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131

Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892

Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis

Citraro, R., Leo, A., Santoro, M., D’Agostino, G., Constanti, A., & Russo, E. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171024130001 · Cited by 58

Epigenetics in Neurodegenerative Diseases: The Role of Histone Deacetylases

Sharma, S., Sarathlal, K. C., & Taliyan, R. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666181004155136 · Cited by 58

Age-related memory decline, dysfunction of the hippocampus and therapeutic opportunities

Dahan, L., Rampon, C., & Florian, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109943 · Cited by 62

Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions

Prasanth, M. I., Sivamaruthi, B. S., Cheong, C. S. Y., Verma, K., Tencomnao, T., Brimson, J. M., & Prasansuklab, A. (2024) · Antioxidants · doi:10.3390/antiox13050606 · Cited by 65

Epigenetic regulation in memory and cognitive disorders

Rudenko, A., & Tsai, L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.034 · Cited by 58

Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-dependent Cognitive Decline

Végh, M. J., Rausell, A., Loos, M., Heldring, C. M., Jurkowski, W., van Nierop, P., Paliukhovich, I., Li, K. W., del Sol, A., Smit, A. B., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.032086 · Cited by 60

Epigenomics and the Regulation of Aging

Boyd-Kirkup, J. D., Green, C. D., Wu, G., Wang, D., & Han, J. J. (2013) · Epigenomics · doi:10.2217/epi.13.5 · Cited by 57

Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer’s Mice and in Human Patients

Plagg, B., Ehrlich, D., Kniewallner, K. M., Marksteiner, J., & Humpel, C. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150710114256 · Cited by 58

Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B

Sharma, M., Shetty, M. S., Arumugam, T. V., & Sajikumar, S. (2015) · Scientific Reports · doi:10.1038/srep16616 · Cited by 55

Regulating Chromatin by Histone Acetylation

Steunou, A., Rossetto, D., & Côté, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8624-4_4 · Cited by 58

Genome-wide analysis of H4K5 acetylation associated with fear memory in mice

Park, C., Rehrauer, H., & Mansuy, I. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-539 · Cited by 58

Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate

da Silva, P. F., Garcia, V. A., Dornelles, A. D. S., da Silva, V. K., Maurmann, N., Portal, B. C. D., Ferreira, R. D. P., Piazza, F. C., Roesler, R., & Schröder, N. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.038 · Cited by 59

Epigenetic Regulation of Memory by Acetylation and Methylation of Chromatin: Implications in Neurological Disorders, Aging, and Addiction

Sen, N. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8306-x · Cited by 58

Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases

Irwin, M. H., Moos, W. H., Faller, D. V., Steliou, K., & Pinkert, C. A. (2016) · Drug Development Research · doi:10.1002/ddr.21294 · Cited by 57

Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex

Ianov, L., Rani, A., Beas, B. S., Kumar, A., & Foster, T. C. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00113 · Cited by 55

Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

Schroeder, F. A., Gilbert, T. M., Feng, N., Taillon, B. D., Volkow, N. D., Innis, R. B., Hooker, J. M., & Lipska, B. K. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00372 · Cited by 61

How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span

Galow, A.-M., & Peleg, S. (2022) · Cells · doi:10.3390/cells11030468 · Cited by 60

Insulin growth factor binding protein 7 is a novel target to treat dementia

Agbemenyah, H. Y., Agís‐Balboa, R. C., Burkhardt, S., Delalle, I., & Fischer, A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.011 · Cited by 55

Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids

Rodrigues, A. J., Leão, P., Pêgo, J. M., Cardona, D., Carvalho, M. M., de Oliveira, M. M., Costa, B. M., Carvalho, A. F., Morgado, P. F., Araújo, D., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.126 · Cited by 57

Histone acetylation in neuronal (dys)function

Bonnaud, E. M., Suberbielle, E., & Malnou, C. E. (2016) · BioMolecular Concepts · doi:10.1515/bmc-2016-0002 · Cited by 58

Neuroepigenetic signatures of age and sex in the living human brain

Gilbert, T. M., Zürcher, N. R., Catanese, M. C., Tseng, C.-E. J., Biase, M. A. D., Lyall, A. E., Hightower, B. G., Parmar, A. J., Bhanot, A., Wu, C. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11031-0 · Cited by 55

From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein

Octave, J., Pierrot, N., Santos, S. F., Nalivaeva, N., & Turner, A. J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12239 · Cited by 54

Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism

Lorbeck, M. T., Pirooznia, K., Sarthi, J. B., Zhu, X., & Elefant, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018412 · Cited by 57

Nutritional influence on epigenetics and effects on longevity

Niculescu, M. D., & Lupu, D. S. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328340ff7c · Cited by 55

Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

Wang, J., Gong, B., Zhao, W., Tang, C. Y., Varghese, M., Nguyen, T., Bi, W., Bilski, A. E., Begum, S., Vempati, P., et al. (2013) · Diabetes · doi:10.2337/db13-1063 · Cited by 55

Promoter DNA methylation regulates progranulin expression and is altered in FTLD

Banzhaf‐Strathmann, J., Claus, R., Mücke, O., Rentzsch, K., van der Zee, J., Engelborghs, S., Deyn, P. P. D., Cruts, M., Broeckhoven, C. V., Plass, C., et al. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-16 · Cited by 53

The impact of histone post-translational modifications in neurodegenerative diseases

Cobos, S. N., Bennett, S. A., & Torrente, M. P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.019 · Cited by 53

Methylation polymorphism influences practice effects in children during attention tasks

Voelker, P., Sheese, B. E., Rothbart, M. K., & Posner, M. I. (2016) · Cognitive Neuroscience · doi:10.1080/17588928.2016.1170006 · Cited by 55

Formins in Human Disease

Labat‐de‐Hoz, L., & Alonso, M. A. (2021) · Cells · doi:10.3390/cells10102554 · Cited by 59

Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors

Hasan, A., Mitchell, A., Schneider, A., Halene, T. B., & Akbarian, S. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0395-2 · Cited by 52

The anaphase promoting complex is required for memory function in micePreprint

Kuczera, T., Stilling, R. M., Hsia, H., Bahari‐Javan, S., Irniger, S., Nasmyth, K., Sananbenesi, F., & Fischer, A. (2010) · Learning & Memory · doi:10.1101/lm.1998411 · Cited by 51

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes

Sandovici, I., Hammerle, C. M., Ozanne, S. E., & Constância, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1297-1 · Cited by 52

Diacylglycerol kinase as a possible therapeutic target for neuronal diseases

Shirai, Y., & Saito, N. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-28 · Cited by 54

Epigenetics and Cognitive Aging

Sweatt, J. D. (2010) · Science · doi:10.1126/science.1189968 · Cited by 50

Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities

Pirooznia, S. K., & Elefant, F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00030 · Cited by 53

Epigenetic mechanisms in epilepsy

Kobow, K., & Blümcke, I. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63326-2.00014-4 · Cited by 57

Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition

Panikker, P., Xu, S., Zhang, H., Sarthi, J. B., Beaver, M., Sheth, A., Akhter, S., & Elefant, F. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2840-17.2018 · Cited by 51

Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex

Basu, T., O’Riordan, K. J., Schoenike, B. A., Khan, N., Wallace, E. P., Rodriguez, G., Maganti, R. K., & Roopra, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-41744-7 · Cited by 50

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

Burns, A. M., Farinelli-Scharly, M., Hugues-Ascery, S., Sanchez-Mut, J. V., Santoni, G., & Gräff, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116797119 · Cited by 49

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

Baker, D. J., & Peleg, S. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.06.005 · Cited by 48

Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia

Agís‐Balboa, R. C., Pinheiro, P. S., Rebola, N., Kerimoglu, C., Benito, E., Gertig, M., Bahari‐Javan, S., Jain, G., Burkhardt, S., Delalle, I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796821 · Cited by 55

Post-translational modifications in MeHg-induced neurotoxicity

Ke, T., Gonçalves, F. M., Gonçalves, C. L., dos Santos, A. A., da Rocha, J. B. T., Farina, M., Skalny, A. V., Tsatsakis, A. M., Bowman, A. B., & Aschner, M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.024 · Cited by 47

Visualizing epigenetics: Current advances and advantages in HDAC PET imaging techniques

Wang, C., Schroeder, F. A., & Hooker, J. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.018 · Cited by 48

Monoaminergic and Neuropeptidergic Neurons Have Distinct Expression Profiles of Histone Deacetylases

Takase, K., Oda, S., Kuroda, M., & Funato, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058473 · Cited by 47

Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation

Wee, C. L., Teo, S., Oey, N. E., Wright, G. D., VanDongen, H. M. A., & VanDongen, A. M. J. (2014) · eNeuro · doi:10.1523/eneuro.0019-14.2014 · Cited by 46

Multi-input Synapses, but Not LTP-Strengthened Synapses, Correlate with Hippocampal Memory Storage in Aged Mice

Aziz, W., Kraev, I., Mizuno, K., Kirby, A. J., Fang, T., Rupawala, H., Kasbi, K., Rothe, S., Jozsa, F., Rosenblum, K., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.064 · Cited by 45

Memory Deficits in Aging and Neurological Diseases

Khan, Z. U., Martín‐Montañez, E., Navarro‐Lobato, I., & Muly, E. C. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-420170-5.00001-5 · Cited by 48

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

Chai, G., Feng, Q., Wang, Z.-H., Hu, Y., Sun, D., Li, X., Ke, D., Li, H., Liu, G., & Wang, J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0178-8 · Cited by 45

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

Borges, J. V., de Freitas, B. S., Antoniazzi, V., dos Santos, C. D. S., Vedovelli, K., Pires, V. N., Paludo, L., de Lima, M. N. M., & Bromberg, E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.025 · Cited by 45

From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health

Mews, P., Calipari, E. S., Day, J. J., Lobo, M. K., Bredy, T. W., & Abel, T. G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1649-20.2020 · Cited by 42

Effect of elevated CO 2 on the interaction between invasive thrips, Frankliniella occidentalis , and its host kidney bean, Phaseolus vulgaris

Qian, L., He, S., Liu, X., Huang, Z., Chen, F., & Gui, F. (2018) · Pest Management Science · doi:10.1002/ps.5064 · Cited by 44

The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer’s Disease

Wood, I. C. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00649 · Cited by 44

A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice

Thau‐Zuchman, O., Svendsen, L., Dyall, S. C., Paredes, U. M., Rhodes, M., Priestley, J. V., Feichtinger, R. G., Kofler, B., Lotstra, S., Verkuyl, J. M., et al. (2020) · Theranostics · doi:10.7150/thno.48995 · Cited by 45

Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)

Nagarajan, P., Agudelo Garcia, P. A., Iyer, C. C., Popova, L. V., Arnold, W. D., & Parthun, M. R. (2019) · Aging Cell · doi:10.1111/acel.12992 · Cited by 43

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Pascoal, T. A., Chamoun, M., Lax, E., Wey, H.-Y., Shin, M., Ng, K. P., Kang, M. S., Mathotaarachchi, S., Benedet, A. L., Therriault, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30653-5 · Cited by 43

Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation

Alexander, D. C., Corman, T. S., Mendoza, M. R., Glass, A., Belity, T., Wu, R., Campbell, R. R., Han, J., Keiser, A. A., Winkler, J. D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114758119 · Cited by 42

Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure

Dominguez, G., Dagnas, M., Decorte, L., Vandesquille, M., Belzung, C., Béracochéa, D., & Mons, N. E. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0941-3 · Cited by 44

Generating new neurons to circumvent your fears: the role of IGF signaling

Agís‐Balboa, R. C., & Fischer, A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1316-2 · Cited by 43

Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer’s disease

Liu, R., Lei, J. X., Luo, C., Lan, X., Chi, L., Deng, P., Lei, S., Ghribi, O., & Liu, Q. Y. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.007 · Cited by 42

Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues

Takasugi, M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.12.003 · Cited by 43

Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate

Zhong, T., Qing, Q. J., Yang, Y., Zou, W. Y., Ye, Z., Yan, J. Q., & Guo, Q. L. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu184 · Cited by 43

The roles of class I histone deacetylases (HDACs) in memory, learning, and executive cognitive functions: A review

Schmauss, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.004 · Cited by 48

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Creighton, S. D., Stefanelli, G., Reda, A. J., & Zovkic, I. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186918 · Cited by 45

Regulation of Gene Expression and Pain States by Epigenetic Mechanisms

Géranton, S. M., & Tochiki, K. K. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.11.012 · Cited by 44

Emerging topics in epigenetics: ants, brains, and noncoding RNAs

Bonasio, R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06363.x · Cited by 42

Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα

Zhang, Y., Wu, K., Su, W., Zhang, D., Wang, P., Qiao, X., Yao, Q., Yuan, Z., Yao, Y., Liu, G., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0681-17.2017 · Cited by 43

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

Lardenoije, R., van den Hove, D., Havermans, M., van Casteren, A., Le, K. X., Palmour, R., Lemere, C. A., & Rutten, B. P. F. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.11.002 · Cited by 42

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

Leung, H.-W., Foo, G., & VanDongen, A. M. J. (2022) · Biomedicines · doi:10.3390/biomedicines10081946 · Cited by 41

Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

Bahari‐Javan, S., Sananbenesi, F., & Fischer, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00160 · Cited by 40

Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of d-galactose

Garcez, M. L., de Carvalho, C. A., Mina, F., Bellettini-Santos, T., Schiavo, G. L., da Silva, S., Campos, A. C. B. F., Varela, R. B., Valvassori, S. S., Damiani, A. P., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.10.005 · Cited by 41

Bridging Synaptic and Epigenetic Maintenance Mechanisms of the Engram

Kyrke‐Smith, M., & Williams, J. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00369 · Cited by 43

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina, E., Shaposhnikov, M. V., & Moskalev, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124484 · Cited by 42

Neuronal epigenetics and the aging synapse

Azpurua, J., & Eaton, B. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00208 · Cited by 39

Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline

Deibel, S. H., Zelinski, E. L., Keeley, R. J., Kovalchuk, O., & McDonald, R. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4036 · Cited by 40

Histone acetylation dependent energy landscapes in tri-nucleosome revealed by residue-resolved molecular simulations

Chang, L., & Takada, S. (2016) · Scientific Reports · doi:10.1038/srep34441 · Cited by 40

Post-occlusion administration of sodium butyrate attenuates cognitive impairment in a rat model of chronic cerebral hypoperfusion

Liu, H., Zhang, J., Xiong, L., Yang, Y., Xie, X., & Hu, K. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.05.012 · Cited by 40

Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5α-reductase type 1 gene in the rat hippocampus

Rossetti, M. F., Varayoud, J., Moreno-Piovano, G. S., Luque, E. H., & Ramos, J. G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.024 · Cited by 40

Epigenetic nutraceutical diets in Alzheimer's disease

Davinelli, S., Calabrese, V., Zella, D., & Scapagnini, G. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0552-y · Cited by 42

Memory and Self–Neuroscientific Landscapes

Markowitsch, H. J. (2013) · ISRN Neuroscience · doi:10.1155/2013/176027 · Cited by 43

Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a

Jiang, W., Cao, L., Wang, F., Ge, H., Wu, P.-C., Li, X.-W., & Chen, G.-H. (2016) · AGE · doi:10.1007/s11357-016-9947-5 · Cited by 40

Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form

Werner, M. S., Loschko, T., King, T., Reich, S., Theska, T., Franz‐Wachtel, M., Maček, B., & Sommer, R. J. (2023) · Nature Communications · doi:10.1038/s41467-023-37734-z · Cited by 39

The path to epigenetic treatment of memory disorders

Mikaelsson, M. A., & Miller, C. A. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.003 · Cited by 40

Valproate Improves Memory Deficits in an Alzheimer’s disease Mouse Model: Investigation of Possible Mechanisms of Action

Yao, Z., Liang, L., Liu, Y., Zhang, L., Zhu, H., Huang, L., & Qin, C. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-0012-y · Cited by 43

Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease

Engmann, O., Hortobágyi, T., Thompson, A., Guadagno, J., Troakes, C., Soriano, S., Al‐Sarraj, S., Kim, Y. D., & Giese, K.-P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.011 · Cited by 38

Swimming exercise ameliorates neurocognitive impairment induced by neonatal exposure to isoflurane and enhances hippocampal histone acetylation in mice

Zhong, T., Ren, F., Huang, C., Zou, W., Yu, Y., Pan, Y., Sun, B., Wang, E., & Guo, Q. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.049 · Cited by 39

Multiple roles of the actin and microtubule-regulating formins in the developing brain

Galbraith, K. K., & Kengaku, M. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.09.008 · Cited by 38

Epigenetic contributions to cognitive aging: disentangling mindspan and lifespanPreprint

Spiegel, A. M., Sewal, A. S., & Rapp, P. R. (2014) · Learning & Memory · doi:10.1101/lm.033506.113 · Cited by 38

TIP60 in aging and neurodegeneration

Li, Z., & Rasmussen, L. J. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101195 · Cited by 37

Epigenetics of Alzheimer's Disease and Frontotemporal Dementia

Veerappan, C. S., Sleiman, S. F., & Coppola, G. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0219-0 · Cited by 38

Epigenetic drugs in Alzheimer’s disease

Cuadrado‐Tejedor, M., Oyarzábal, J., Pascual‐Lucas, M., Franco, R., & García‐Osta, A. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2013-0012 · Cited by 37

Epigenetic Modifications in Neurons are Essential for Formation and Storage of Behavioral Memory

Day, J. J., & Sweatt, J. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.125 · Cited by 38

Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders

Lardenoije, R., Pishva, E., Lunnon, K., & van den Hove, D. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.008 · Cited by 37

Chromatin regulation and dynamics in stem cells

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Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases

Wang, L., Yu, C.-C., Liu, X., Deng, X., Tian, Q., & Du, Y. (2021) · Neural Plasticity · doi:10.1155/2021/9912686 · Cited by 41

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, attenuates postoperative cognitive dysfunction in aging mice

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Epigenetics, Oestradiol and Hippocampal Memory Consolidation

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Lockett, G. A., Wilkes, F., & Maleszka, R. (2010) · Neuroreport · doi:10.1097/wnr.0b013e32833e9288 · Cited by 38

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Science

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari‐Javan, S., Agis-Balboa, R., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · MPG.PuRe (Max Planck Society)

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Peleg, S. (2010) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3189

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Bhatt, S. R., MacBean, L. F., Kramár, E. A., Pérez‐Sisqués, L., Smethurst, P., Robb, J. L., Jindal, N., Fetterly, T. L., Graham, A., Wood, M. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.695858

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Scheinman, S. B., Carvill, G. L., & Dong, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5045299

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Morse, S. J., Butler, A. A., Davis, R. L., Soller, I., & Lubin, F. D. (2015) · Biology · doi:10.3390/biology4020298 · Cited by 81