Cited by 951Memory and Neural MechanismsGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Abstract

As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain.

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Crossref · 10.1126/science.1186088

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Metadata

Authors
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., Salinas-Riester, G., Dettenhofer, M., Kang, H., Farinelli, L., Chen, W., & Fischer, A.
Affiliations
  • European Neuroscience Institute Göttingen (DE)
  • Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str. 5, D-37077 Goettingen, Germany.
  • Max Delbrueck Center for Molecular Medicine, Institute for Medical Systems Biology, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.
  • University of Göttingen (DE)
  • Harvard University (US)
  • Max Delbrück Center (DE)
  • Fasteris SA, CH-1228 Plan-les-Ouates, Switzerland.
Corresponding author
  • Peleg, Shahaf
  • Sananbenesi, Farahnaz
  • Zovoilis, Athanasios
  • Fischer, André
Venue
Science
Published
2010-05-07
Volume
328
Issue
5979
Pages
753-756
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2149591661
Cited by
951
References
24
Citations by year
2026: 16 · 2025: 30 · 2024: 51 · 2023: 38 · 2022: 42 · 2021: 50 · 2020: 52 · 2019: 50 · 2018: 60 · 2017: 60 · 2016: 81 · 2015: 77 · 2014: 76 · 2013: 94 · 2012: 73
FWCI
51.84
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • GRO (submittedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
histone acetylation, H4K12 acetylation, hippocampus, chromatin plasticity, memory consolidation, cognitive decline, brain aging, biomarkers, gene-environment interaction
MeSH terms
Formins, Acetylation, Aging, Animals, Chromatin, Conditioning, Psychological, Fear, Gene Expression Regulation, Hippocampus, Histones, Hydroxamic Acids, Learning, Lysine, Memory, Memory Disorders, Mice, Inbred C57BL, Microfilament Proteins, Nerve Tissue Proteins, Nuclear Proteins, Transcription, Genetic, Signal Transduction, Up-Regulation, Gene Expression Profiling, Transcription Initiation Site, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Histone Deacetylase Inhibitors

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