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Development of the Hippocampal Cognitive Map in Preweanling Rats

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Wills, Tom J., Cacucci, Francesca, Burgess, Neil, O'Keefe, John·2010·Science
DOI 10.1126/science.1188224PMC PMC3543985
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Abstract

The Space in Your Head Space, and events associated with places and spaces, are represented in the brain by a circuitry made of place cells, head direction cells, grid cells, and border cells. These cell types form a collective dynamic representation of our position as we move through the environment. How this representation is formed has remained a mystery. Is it acquired, or are we born with the ability to represent external space (see the Perspective by Palmer and Lynch )? Langston et al. (p. 1576 ) and Wills et al. (p. 1573 ) investigated the early development of spatial activity in the hippocampal formation and the entorhinal cortex of rat pups when they first began to explore their environment. Rudiments of place cells, head direction cells, and grid cells already existed when the pups made their first movements out of the nest. A neural representation of external space at this early time points to strong innate components for perception of space. These findings provide experimental support for Kant's 200-year-old concept of space as an a priori faculty of the mind.

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  • Larval zebrafish PCs with spatial tuning near boundaries may be more functionally analogous to the high density of PCs observed near boundaries in juvenile rodents.

    “they may be more functionally analogous to the high density of PCs observed near boundaries in juvenile rodents46,47.”

    From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [47]

    The paper’s main text (indexed under Abstract; page unavailable) reports place cells in preweanling rats and suggests that boundary-vector cells could provide input to them. It does not report a high density of place cells with firing fields near environmental boundaries; its finding of more directional cells near a border concerns a brain-region border, not enclosure boundaries. (LLM, conf=0.78)

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Research works printed but not linked: 28

  1. [1]O’Keefe J Nadel L The hippocampus as a cognitive map 1978 Oxford University Press
  2. [2]Schenk F Behav. Neural Biol 1985 43 69 3994625
  3. [3]Rudy JW Stadler-Morris S Albert P Behav. Neurosci 1987 101 62 3828056
  4. [5]O’Keefe J Dostrovsky J Brain Res 1971 34 171 5124915
  5. [6]Hafting T Fyhn M Molden S Moser MB Moser EI Nature 2005 436 801 15965463
  6. [7]Taube JS Muller RU Ranck JB Jr. J. Neurosci 1990 10 420 2303851 PMC6570151
  7. [8]Gerrish CJ Alberts JR Dev. Psychobiol 1996 29 483 8872422
  8. [9]Skaggs WE McNaughton BL Gothard KM Markus EJ Adv. Neural Inf. Process Syst 1993 vol. 5 1030 1037 Morgan Kaufmann San Mateo, CA
  9. [10]Barry C Hayman R Burgess N Jeffery KJ Nat. Neurosci 2007 10 682 17486102
  10. [12]Lever C Wills T Cacucci F Burgess N O’Keefe J Nature 2002 416 90 11882899
  11. [13]O’Keefe J Recce ML Hippocampus 1993 3 317 8353611
  12. [14]Hafting T Fyhn M Bonnevie T Moser MB Moser EI Nature 2008 453 1248 18480753
  13. [15]Burgess N Barry C O’Keefe J Hippocampus 2007 17 801 17598147 PMC2678278
  14. [16]Giocomo LM Zilli EA Fransen E Hasselmo ME Science 2007 315 1719 17379810 PMC2950607
  15. [17]Rivas J Gaztelu JM Garcia-Austt E Exp. Brain Res 1996 108 113 8721159
  16. [18]Jeewajee A Barry C O’Keefe J Burgess N Hippocampus 2008 18 1175 19021251 PMC3173868
  17. [19]Leblanc MO Bland BH Exp. Neurol 1979 66 220 226389
  18. [20]Burton BG Economo MN Lee GJ White JA J. Neurophysiol 2008 100 3144 18829850 PMC2604849
  19. [21]McNaughton BL Battaglia FP Jensen O Moser EI Moser MB Nat. Rev. Neurosci 2006 7 663 16858394
  20. [22]Lever C Burton S Jeewajee A O’Keefe J Burgess N J. Neurosci 2009 29 9771 19657030 PMC2736390
  21. [23]Solstad T Boccara CN Kropff E Moser MB Moser EI Science 2008 322 1865 19095945
  22. [24]Savelli F Yoganarasimha D Knierim JJ Hippocampus 2008 18 1270 19021262 PMC3007674
  23. [25]Van Cauter T Poucet B Save E Eur. J. Neurosci 2008 27 1933 18412614
  24. [26]Brun VH Neuron 2008 57 290 18215625
  25. [27]Harvey CD Collman F Dombeck DA Tank DW Nature 2009 461 941 19829374 PMC2771429
  26. [28]Martin PD Berthoz A Hippocampus 2002 12 465 12201631
  27. [29]Cheng K Cognition 1986 23 149 3742991
  28. [30]Hermer L Spelke ES Nature 1994 370 57 8015605

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Authors
Wills, T. J., Cacucci, F., Burgess, N., & O'Keefe, J.
Affiliations
  • Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • University College London (GB)
  • UCL Queen Square Institute of Neurology (GB)
Corresponding author
Cacucci, Francesca
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2010-06-18
Volume
328
Issue
5985
Pages
1573-1576
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1188224
PMC
PMC3543985
OpenAlex
W1968023011
Cited by
616
References
1
Citations by year
2026: 17 · 2025: 24 · 2024: 64 · 2023: 21 · 2022: 25 · 2021: 30 · 2020: 59 · 2019: 31 · 2018: 36 · 2017: 41 · 2016: 29 · 2015: 49 · 2014: 64 · 2013: 40 · 2012: 42
FWCI
24.44
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust (082507)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
spatial representation, place cells, head direction cells, grid cells, border cells, entorhinal cortex, preweanling rats, Immanuel Kant
MeSH terms
Action Potentials, Aging, Animals, Animals, Suckling, Brain Mapping, Cognition, Electrodes, Implanted, Exploratory Behavior, Male, Neurons, Orientation, Space Perception, Spatial Behavior, Theta Rhythm, Pyramidal Cells, Entorhinal Cortex, Rats, CA1 Region, Hippocampal

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