New and Distinct Hippocampal Place Codes Are Generated in a New Environment during Septal Inactivation
Open accessAbstract
The hippocampus generates distinct neural codes to disambiguate similar experiences, a process thought to underlie episodic memory function. Entorhinal grid cells provide a prominent spatial signal to hippocampus, and changes in their firing pattern could thus generate a distinct spatial code in each context. We examined whether we would preclude the emergence of new spatial representations in a novel environment during muscimol inactivation of the medial septal area, a manipulation known to disrupt theta oscillations and grid cell firing. We found that new, highly distinct configurations of place fields emerged immediately and remained stable during the septal inactivation. The new place code persisted when theta oscillations had recovered. Theta rhythmicity and feedforward input from grid cell networks were thus not required to generate new spatial representations in the hippocampus.
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Recent experimental evidence suggests that grid cells are not necessary for learning and continued functioning of place cells.
“Recent experimental evidence suggests that grid cells are not necessary for learning (54, 55) and continued functioning of place cells (55).”
From Space is a latent sequence: A theory of the hippocampus (2024) · cites this paper as [55]
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- Authors
- Brandon, M. P., Koenig, J., Leutgeb, J. K., & Leutgeb, S.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Leutgeb, Stefan
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 82
- Issue
- 4
- Pages
- 789-796
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4294702
- OpenAlex
- W2023320179
- Cited by
- 145
- References
- 61
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 16 · 2017: 17 · 2016: 10 · 2015: 20 · 2014: 11
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (FMH096531A)
- National Institute of Mental Health (R21MH100354, F32MH096531)
- National Institute of Neurological Disorders and Stroke (R01NS086947)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- place fields, muscimol, theta oscillations, grid cells, entorhinal cortex, spatial representation, episodic memory, novel environment
- MeSH terms
- Action Potentials, Animals, Brain Mapping, Conditioning, Operant, Environment, Exploratory Behavior, Hippocampus, Male, Muscimol, Neural Pathways, Space Perception, Statistics, Nonparametric, Rats, Long-Evans, Septum of Brain, Rats, GABA-A Receptor Agonists
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