Emergence of preconfigured and plastic time-compressed sequences in early postnatal development
Open accessAbstract
Memory capabilities develop with age: During memory formation, time-compressed neuronal sequences underlie consolidation as well as encoding of novel information. Such memory traces are largely contributed by a selection of preconfigured neuronal patterns. However, when and how these preconfigured patterns first emerge in the hippocampus is unknown. Farooq and Dragoi identified an age-dependent development of network preconfiguration into trajectory-like sequences. This preconfiguration was expressed spontaneously during sleep and emerged from the assembly of persistent, location-depicting ensembles, largely controlled by intrinsic developmental programs. Thus, the compressed binding of adjacent locations into spatial trajectories during navigation and their experience-dependent replay emerge in coordination from spontaneous preconfigured sequences. Science , this issue p. 168
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In the rodent hippocampus, at the end of the first postnatal week, sharp wave bursts can be detected, while SPW-Rs in conjunction with neuronal reactivations only emerge at the end of the second postnatal week.
“In the rodent hippocampus, at the end of the first postnatal week, ''sharp wave bursts,'' as a first organized network event can be detected, while SPW-Rs in conjunction with neuronal reactivations only emerge at the end of the second postnatal week.255,256”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [256]
The paper’s account of awake rest and sleep reports location-depicting neuronal activity at P15–P16, and says spatial experience–depicting frames co-occurred with ripple oscillations (Fig. 3–4 passages; page unavailable). Its recordings began at P15, however, so it does not establish when sharp-wave bursts first appear in postnatal week one or that SPW-Rs with neuronal reactivation first emerge at the end of week two. (LLM, conf=0.76)
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- Authors
- Farooq, U., & Dragoi, G.
- Affiliations
- Yale University (US)
- Corresponding author
- Dragoi, G.
- ORCID
- Venue
- Science
- Published
- 2019-01-11
- Volume
- 363
- Issue
- 6423
- Pages
- 168-173
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6794005
- OpenAlex
- W2908664654
- Cited by
- 131
- References
- 31
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 22 · 2023: 23 · 2022: 15 · 2021: 27 · 2020: 11 · 2019: 7
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brain and Behavior Research Foundation
- Whitehall Foundation
- Charles H. Hood Foundation
- Gruber Foundation
- NINDS
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- postnatal development, hippocampal replay, sleep, memory consolidation, episodic memory, spatial navigation
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Male, Neurons, Sleep, Theta Rhythm, Rats, Long-Evans, Rats, Electrophysiological Phenomena, CA1 Region, Hippocampal, Memory, Episodic, Spatial Memory
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