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Genotype to Phenotype: A Complex Problem
Abstract
In yeast, the impact of gene knockouts depends on genetic background.
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Genetic background has long been known to influence observed phenotypic expression across organisms.
“genetic background has long been known to influence observed phenotypic expression across organisms”
From Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development (2016) · cites this paper as [72]
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Cites
The Genetic Landscape of a Cell
Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162
Self-citationThe diploid genome sequence of an Asian individual
Wang, J., Wang, W., Li, R., Li, Y., Tian, G., Goodman, L., Fan, W., Zhang, J., Li, J., Zhang, J., et al. (2008) · Nature · doi:10.1038/nature07484 · Cited by 924
Rare Variants Create Synthetic Genome-Wide Associations
Dickson, S. P., Wang, K., Krantz, I., Hakonarson, H., & Goldstein, D. B. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000294 · Cited by 857
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Research works printed but not linked: 3
- 10.1126/science.1149504 · DOI · Paper page
- 10.1126/science.291.5506.1001 · DOI · Paper page
- 10.1038/nature00935 · DOI · Paper page
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A global genetic interaction network maps a wiring diagram of cellular function
Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240
Self-citationNew genes as drivers of phenotypic evolution
Chen, S., Krinsky, B. H., & Long, M. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3521 · Cited by 428
The Causes and Consequences of Genetic Interactions (Epistasis)
Domingo, J., Baeza-Centurion, P., & Lehner, B. (2019) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083118-014857 · Cited by 242
Global Genetic Networks and the Genotype-to-Phenotype Relationship
Costanzo, M., Kuzmin, E., van Leeuwen, J., Mair, B., Moffat, J., Boone, C., & Andrews, B. (2019) · Cell · doi:10.1016/j.cell.2019.01.033 · Cited by 241
Self-citationMapping of signaling networks through synthetic genetic interaction analysis by RNAi
Horn, T., Sandmann, T., Fischer, B., Axelsson, E., Huber, W., & Boutros, M. (2011) · Nature Methods · doi:10.1038/nmeth.1581 · Cited by 193
Segal, E. S., Gritsenko, V., Levitan, A., Yadav, B., Dror, N., Steenwyk, J. L., Silberberg, Y., Mielich, K., Rokas, A., Gow, N. A. R., et al. (2018) · mBio · doi:10.1128/mbio.02048-18 · Cited by 150
Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution
Todd, R. T., Forche, A., & Selmecki, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0051-2016 · Cited by 121
Genotype to phenotype via network analysis
Carter, H., Hofree, M., & Ideker, T. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.10.003 · Cited by 132
Genetic contributions to behavioural diversity at the gene-environment interface
Bendesky, A., & Bargmann, C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3065 · Cited by 103
Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
De Kegel, B., & Ryan, C. J. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008466 · Cited by 92
Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
Ettleson, M. D., & Bianco, A. C. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa430 · Cited by 75
Conserved rules govern genetic interaction degree across species
Koch, E. N., Costanzo, M., Bellay, J., Deshpande, R., Chatfield-Reed, K., Chua, G., D'Urso, G., Andrews, B. J., Boone, C., & Myers, C. L. (2012) · Genome Biology · doi:10.1186/gb-2012-13-7-r57 · Cited by 68
Self-citationExercise genomics—a paradigm shift is needed: a commentary
Bouchard, C. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095294 · Cited by 63
Anderson, M. Z., Saha, A., Haseeb, A., & Bennett, R. J. (2017) · Microbiology · doi:10.1099/mic.0.000478 · Cited by 53
Teyssonnière, E. M., Trébulle, P., Muenzner, J., Loegler, V., Ludwig, D., Amari, F., Mülleder, M., Friedrich, A., Hou, J., Ralser, M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319211121 · Cited by 40
Bhattacharyya, S., Rainey, M. A., Arya, P., Mohapatra, B. C., Mushtaq, I., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., et al. (2016) · Scientific Reports · doi:10.1038/srep20727 · Cited by 36
Metadata
- Authors
- Dowell, R. D., Ryan, O., Jansen, A., Cheung, D., Agarwala, S., Danford, T., Bernstein, D. A., Rolfe, P. A., Heisler, L. E., Chin, B., Nislow, C., Giaever, G., Phillips, P. C., Fink, G. R., Gifford, D. K., & Boone, C.
- Affiliations
- Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
- Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
- Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
- Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada.
- Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, OR 97403, USA.
- Venue
- Science
- Published
- 2010-04-23
- Volume
- 328
- Issue
- 5977
- Pages
- 469-469
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC4412269
- Cited by
- 396
- References
- 3
- Language
- en
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