Cited by 654Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

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Regulation of Oligodendrocyte Differentiation and Myelination

Emery, Ben·2010·Science

DOI 10.1126/science.1190927

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Abstract

Despite the importance of myelin for the rapid conduction of action potentials, the molecular bases of oligodendrocyte differentiation and central nervous system (CNS) myelination are still incompletely understood. Recent results have greatly advanced this understanding, identifying new transcriptional regulators of myelin gene expression, elucidating vital roles for microRNAs in controlling myelination, and clarifying the extracellular signaling mechanisms that orchestrate the development of myelin. Studies have also demonstrated an unexpected level of plasticity of myelin in the adult CNS. These recent advances provide new insight into how remyelination may be stimulated in demyelinating disorders such as multiple sclerosis.

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Authors: Emery, B.
Affiliations: The University of Melbourne (AU)
Corresponding author: Emery, Ben
ORCID: Emery, Ben
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-11-05
Volume: 330
Issue: 6005
Pages: 779-782
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1190927
OpenAlex: W2001810970
Cited by: 653
References: 54
Citations by year: 2026: 28 · 2025: 23 · 2024: 37 · 2023: 32 · 2022: 50 · 2021: 46 · 2020: 45 · 2019: 50 · 2018: 32 · 2017: 35 · 2016: 40 · 2015: 54 · 2014: 51 · 2013: 50 · 2012: 39
FWCI: 3.25
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: oligodendrocyte differentiation, myelination, myelin gene expression, transcription factors, microRNA, extracellular signaling, myelin plasticity, remyelination, demyelinating disease, multiple sclerosis, central nervous system
MeSH terms: Animals, Axons, Cell Differentiation, Central Nervous System, Demyelinating Diseases, Gene Expression Regulation, Humans, Myelin Sheath, Oligodendroglia, Transcription, Genetic, Signal Transduction, MicroRNAs, Chromatin Assembly and Disassembly

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